TiO2/CuInS2-sensitized structure for sensitive photoelectrochemical immunoassay of cortisol in saliva

Luo, Dajuan; Liu, Bingqian; Gao, Rong; Su, Lixia; Su, Yonghuan

doi:10.1007/s10008-021-05101-x

Cited by 6 publications

(4 citation statements)

References 47 publications

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“…The presence of the microrobots leads to a notable increase of the SPE’s R ct due to the low conductivity of the semiconducting TiO 2 , which represents the main constituent of the microrobots 66 . This behavior has also been observed after TiO 2 loading on FTO electrodes 67 . The R ct further rises due to the lower microrobots’ conductance in consequence of the inclusion of a large quantity of non-conducting polystyrene nanoparticles 68 .…”

Section: Resultssupporting

confidence: 63%

Trapping and detecting nanoplastics by MXene-derived oxide microrobots

et al. 2022

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Nanoplastic pollution, the final product of plastic waste fragmentation in the environment, represents an increasing concern for the scientific community due to the easier diffusion and higher hazard associated with their small sizes. Therefore, there is a pressing demand for effective strategies to quantify and remove nanoplastics in wastewater. This work presents the “on-the-fly” capture of nanoplastics in the three-dimensional (3D) space by multifunctional MXene-derived oxide microrobots and their further detection. A thermal annealing process is used to convert Ti3C2Tx MXene into photocatalytic multi-layered TiO2, followed by the deposition of a Pt layer and the decoration with magnetic γ-Fe2O3 nanoparticles. The MXene-derived γ-Fe2O3/Pt/TiO2 microrobots show negative photogravitaxis, resulting in a powerful fuel-free motion with six degrees of freedom under light irradiation. Owing to the unique combination of self-propulsion and programmable Zeta potential, the microrobots can quickly attract and trap nanoplastics on their surface, including the slits between multi-layer stacks, allowing their magnetic collection. Utilized as self-motile preconcentration platforms, they enable nanoplastics’ electrochemical detection using low-cost and portable electrodes. This proof-of-concept study paves the way toward the “on-site” screening of nanoplastics in water and its successive remediation.

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Section: Resultssupporting

confidence: 63%

Trapping and detecting nanoplastics by MXene-derived oxide microrobots

et al. 2022

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“…Hg 2+ is linearly and logarithmically correlated in the range between 5 pM and 100 nM. The regression equation was Y = 0.90LogC Hg2+ − 2.40 (R 2 = 0.993), and the calculation formula for detection limit is S/N = 3 [44]. The detection limit was 0.84 pM (Figure 4B).…”

Section: Analytical Performance and Selectivity And Stabilitymentioning

confidence: 95%

Self-Powered Photoelectrochemical Assay for Hg2+ Detection Based on g-C3N4-CdS-CuO Composites and Redox Cycle Signal Amplification Strategy

Liu

et al. 2022

Chemosensors

Self Cite

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A highly sensitive self-powered photoelectrochemical (spPEC) sensing platform was constructed for Hg2+ determination based on the g-C3N4-CdS-CuO co-sensitized photoelectrode and a visible light-induced redox cycle for signal amplification. Through successively coating the single-layer g-C3N4, CdS, and CuO onto the surface of an electrode, the modified electrode exhibited significantly enhanced PEC activity. The microstructure of the material was characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). However, the boost in photocurrent could be noticeably suppressed due to the consumption of hole-scavenging agents (reduced glutathione) by the added Hg2+. Under optimal conditions, we discovered that the photocurrent was linearly related to the Hg2+ concentration in the range of 5 pM–100 nM. The detection limit for Hg2+ was 0.84 pM. Moreover, the spPEC sensor demonstrated good performance for the detection of mercury ions in human urine and artificial saliva.

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“…PEC sensing employs the use of multiple chemical reaction steps to amplify the signal obtained from antigen–antibody binding, utilizing reactions such as enzyme-mediated catalysis, chemical redox cycling, nanomaterial mediated electron excitation, to name a few. As a step up from electrochemical bioanalysis, PEC possesses fast response times, good signal-to-noise ratio and high sensitivity . A competitive assay based on PEC immunosensing was developed with an extremely low LoD of 0.06 pg/mL .…”

Section: Rapid Cortisol Technologiesmentioning

confidence: 99%

“…As a step up from electrochemical bioanalysis, PEC possesses fast response times, good signal-to-noise ratio and high sensitivity. 90 A competitive assay based on PEC immunosensing was developed with an extremely low LoD of 0.06 pg/mL. 91 This type of “signal-on” immunoassay could become routine as PEC based reactions become more commonplace.…”

Section: Rapid Cortisol Technologiesmentioning

confidence: 99%

Advancements in Cortisol Detection: From Conventional Methods to Next-Generation Technologies for Enhanced Hormone Monitoring

Vignesh,

Castro-Dominguez,

James

et al. 2024

ACS Sens.

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The hormone cortisol, released as the end-product of the hypothalamic-pituitary-adrenal (HPA) axis, has a wellcharacterized circadian rhythm that enables an allostatic response to external stressors. When the pattern of secretion is disrupted, cortisol levels are chronically elevated, contributing to diseases such as heart attacks, strokes, mental health disorders, and diabetes. The diagnosis of chronic stress and stress related disorders depends upon accurate measurement of cortisol levels; currently, it is quantified using mass spectroscopy or immunoassay, in specialized laboratories with trained personnel. However, these methods are time-consuming, expensive and are unable to capture the dynamic biorhythm of the hormone. This critical review traces the path of cortisol detection from traditional laboratory-based methods to decentralised cortisol monitoring biosensors. A complete picture of cortisol biology and pathophysiology is provided, and the importance of precision medicine style monitoring of cortisol is highlighted. Antibody-based immunoassays still dominate the pipeline of development of point-of-care biosensors; new capture molecules such as aptamers and molecularly imprinted polymers (MIPs) combined with technologies such as microfluidics, wearable electronics, and quantum dots offer improvements to limit of detection (LoD), specificity, and a shift toward rapid or continuous measurements. While a variety of different sensors and devices have been proposed, there still exists a need to produce quantitative tests for cortisol � using either rapid or continuous monitoring devices that can enable a personalized medicine approach to stress management. This can be addressed by synergistic combinations of technologies that can leverage low sample volumes, relevant limit of detection and rapid testing time, to better account for cortisol's shifting biorhythm. Trends in cortisol diagnostics toward rapid and continuous monitoring of hormones are highlighted, along with insights into choice of sample matrix.

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TiO2/CuInS2-sensitized structure for sensitive photoelectrochemical immunoassay of cortisol in saliva

Cited by 6 publications

References 47 publications

Trapping and detecting nanoplastics by MXene-derived oxide microrobots

Trapping and detecting nanoplastics by MXene-derived oxide microrobots

Self-Powered Photoelectrochemical Assay for Hg2+ Detection Based on g-C3N4-CdS-CuO Composites and Redox Cycle Signal Amplification Strategy

Advancements in Cortisol Detection: From Conventional Methods to Next-Generation Technologies for Enhanced Hormone Monitoring

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