TiO<sub>2</sub> compact layer induced charge transfer enhancement in a three-dimensional TiO<sub>2</sub>–Ag array SERS substrate for quantitative and multiplex analysis

Ding, Zhongxiang; Wang, Yaru; Zhou, Wanpeng; Shui, Yanna; Zhu, Zhengdong; Zhang, Maofeng; Huang, Youju; Jiang, Changlong; Li, Jianhua; Wu, Yucheng

doi:10.1039/d3ra00094j

Cited by 6 publications

(3 citation statements)

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“…198–230 3D bottom-up self-assembly nanostructures are described owing to facile preparation and cost-effectiveness. 231–251 Combinatory detection is used for synergetic enhancements. 252–266…”

Section: Development Of Microdevices For Point-of-care Sers-based Bio...mentioning

confidence: 99%

SERS-based microdevices for use as in vitro diagnostic biosensors

Lee,

Dang,

Moon

et al. 2024

Chem. Soc. Rev.

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Section: Development Of Microdevices For Point-of-care Sers-based Bio...mentioning

confidence: 99%

SERS-based microdevices for use as in vitro diagnostic biosensors

Lee,

Dang,

Moon

et al. 2024

Chem. Soc. Rev.

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“…Solid substrates offer well-defined nanostructures that ensure the uniform and stable distribution of MNPs. As presented in Table 2 , various nanostructured solid substrates have been explored, including the Si micropyramid [ 119 ], Si nanowires [ 120 , 121 ], TiO 2 nanorods [ 122 ], polystyrene (PS) beads [ 123 ], microneedle [ 124 ], ZnO nanopillar [ 125 ], CuO nanorods [ 126 ], and UV curable resin [ 127 ]. In Figure 8 a, it can be observed that MNPs generate hotspots in the nanogaps between them.…”

Section: Design Fabrication and Applications Of Sersmentioning

confidence: 99%

Design, Fabrication, and Applications of SERS Substrates for Food Safety Detection: Review

Lin

et al. 2023

Micromachines

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Sustainable and safe food is an important issue worldwide, and it depends on cost-effective analysis tools with good sensitivity and reality. However, traditional standard chemical methods of food safety detection, such as high-performance liquid chromatography (HPLC), gas chromatography (GC), and tandem mass spectrometry (MS), have the disadvantages of high cost and long testing time. Those disadvantages have prevented people from obtaining sufficient risk information to confirm the safety of their products. In addition, food safety testing, such as the bioassay method, often results in false positives or false negatives due to little rigor preprocessing of samples. So far, food safety analysis currently relies on the enzyme-linked immunosorbent assay (ELISA), polymerase chain reaction (PCR), HPLC, GC, UV-visible spectrophotometry, and MS, all of which require significant time to train qualified food safety testing laboratory operators. These factors have hindered the development of rapid food safety monitoring systems, especially in remote areas or areas with a relative lack of testing resources. Surface-enhanced Raman spectroscopy (SERS) has emerged as one of the tools of choice for food safety testing that can overcome these dilemmas over the past decades. SERS offers advantages over chromatographic mass spectrometry analysis due to its portability, non-destructive nature, and lower cost implications. However, as it currently stands, Raman spectroscopy is a supplemental tool in chemical analysis, reinforcing and enhancing the completeness and coverage of the food safety analysis system. SERS combines portability with non-destructive and cheaper detection costs to gain an advantage over chromatographic mass spectrometry analysis. SERS has encountered many challenges in moving toward regulatory applications in food safety, such as quantitative accuracy, poor reproducibility, and instability of large molecule detection. As a result, the reality of SERS, as a screening tool for regulatory announcements worldwide, is still uncommon. In this review article, we have compiled the current designs and fabrications of SERS substrates for food safety detection to unify all the requirements and the opportunities to overcome these challenges. This review is expected to improve the interest in the sensing field of SERS and facilitate the SERS applications in food safety detection in the future.

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“…Compared with single metal or semiconductor substrates, metal/semiconductor hybrids have many merits to produce high-efficiency SERS signals. The synergistic effect of electromagnetic enhancement and charge transfer can jointly improve the SERS activity. − This phenomenon has been found in many metal/semiconductor hybrids, such as Au/CdS, Ag/GaN, and Au/TiO 2 hybrids. − Meanwhile, the charge transfer efficiency between Raman probe and substrate can be further tuned due to the electron transfer and hot electron injection between metal and semiconductor, which can further improve the SERS activity. − Since the SERS efficiency of metal/semiconductor hybrids is highly dependent on the component, architecture, some effective strategies have been proposed to optimize the SERS performance, such as tuning the metal morphology and adjusting the contact modes. − However, in many metal/semiconductor nanohybrids, the huge near-field enhancement is usually hindered by a semiconductor shell. , Although the charge-transfer efficiency can be improved by plasmonic near-field enhancement, the electromagnetic field is greatly weakened, thus leading to limited SERS improvement. It still remains a challenge to design metal/semiconductor hybrids with simultaneous optimization of near-field enhancement and charge transfer for a highly improved SERS.…”

Section: Introductionmentioning

confidence: 99%

Synergetic Electromagnetic Enhancement and Charger Transfer in Boat-Like Au/PbS/Au Nanohybrids with Increased SERS Activity for Ultrasensitive Molecular Detection

Chen,

Liang,

Lin

et al. 2024

ACS Appl. Nano Mater.

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Metal/semiconductor hybrids are ideal substrates for efficient surfaceenhanced Raman scattering (SERS) due to the cooperation of electromagnetic field and charge transfer, while it remains a challenge to simultaneously optimize the two enhanced mechanisms to achieve higher SERS improvement. Herein, a boat-like Au/ PbS/Au hybrid is synthesized for the first time, which shows improved SERS activity caused by the synergetic effect of huge electromagnetic enhancement and electromagnetic-field-accelerated charge transfer. The boat-like Au/PbS/Au hybrids are prepared by controllably growing the Au shell on the end-exposed Au/PbS nanorods, which has a size-tunable nanocavity at the middle of the nanorod for molecular adsorption and near-field enhancement. As a result, the boat-like Au/PbS/ Au hybrids display excellent SERS efficiency on detecting crystal violet under 785 nm excitation, which is much higher than Au nanorod, Au/PbS, and boat-like Au obtained by in situ removing the PbS shell. The detailed comparison of Raman performances of Au/PbS/Au and boat-like Au as well as the numerical simulations and experimental analysis jointly reveal that the synergistic effect of huge near-field enhancement and the accelerated charge transfer between Au, PbS, and Raman molecules are responsible for the prominent SERS performance. The boat-like Au/PbS/Au can efficiently detect 10 −10 M of crystal violet and thiram, showing great potential in the fields of pollutant detection and food safety.

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TiO₂ compact layer induced charge transfer enhancement in a three-dimensional TiO₂–Ag array SERS substrate for quantitative and multiplex analysis

Abstract: A 3D TiO2–Ag array SERS substrate for rapid quantitative and multiplex analysis of pesticide residues for real samples.

Cited by 6 publications

References 50 publications

SERS-based microdevices for use as in vitro diagnostic biosensors

SERS-based microdevices for use as in vitro diagnostic biosensors

Design, Fabrication, and Applications of SERS Substrates for Food Safety Detection: Review

Synergetic Electromagnetic Enhancement and Charger Transfer in Boat-Like Au/PbS/Au Nanohybrids with Increased SERS Activity for Ultrasensitive Molecular Detection

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TiO2 compact layer induced charge transfer enhancement in a three-dimensional TiO2–Ag array SERS substrate for quantitative and multiplex analysis

Abstract: A 3D TiO2–Ag array SERS substrate for rapid quantitative and multiplex analysis of pesticide residues for real samples.

Cited by 6 publications

References 50 publications

SERS-based microdevices for use as in vitro diagnostic biosensors

SERS-based microdevices for use as in vitro diagnostic biosensors

Design, Fabrication, and Applications of SERS Substrates for Food Safety Detection: Review

Synergetic Electromagnetic Enhancement and Charger Transfer in Boat-Like Au/PbS/Au Nanohybrids with Increased SERS Activity for Ultrasensitive Molecular Detection

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Product

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TiO₂ compact layer induced charge transfer enhancement in a three-dimensional TiO₂–Ag array SERS substrate for quantitative and multiplex analysis