TiO<sub>2</sub>-coated luminescent porous silicon micro-particles as a promising system for nanomedicine

Chistè, Elena; Ghafarinazari, A.; Donini, Marta; Cremers, Véronique; Dendooven, Jolien; Detavernier, Christophe; Benati, Donatella; Scarpa, Marina; Dusi, Stefano; Daldosso, N.

doi:10.1039/c7tb02614e

Cited by 15 publications

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this regard, it has been reported that the microbial chemoattractant N-formyl-methionyl-leucyl-phenylalanine (fMLP) synergized the ability of ORMOSIL nanoparticles to stimulate the release of cytokines by human leukocytes [ 45 ]. Moreover, the simultaneous addition of LPS and porous silicon-TiO 2 microparticles was much more effective than incubation with LPS alone to induce IL-12 and TNF-α secretion by human DCs [ 46 ]. Therefore a synergy between nanoparticles and microbial molecules is not a so rare and unexpected event, although it is usually poorly studied by researchers dealing with nanostructures.…”

Section: Discussionmentioning

confidence: 99%

Oxyresveratrol-Loaded PLGA Nanoparticles Inhibit Oxygen Free Radical Production by Human Monocytes: Role in Nanoparticle Biocompatibility

et al. 2021

Self Cite

View full text Add to dashboard Cite

Oxyresveratrol, a polyphenol extracted from the plant Artocarpus lakoocha Roxb, has been reported to be an antioxidant and an oxygen-free radical scavenger. We investigated whether oxyresveratrol affects the generation of superoxide anion (O2−) by human monocytes, which are powerful reactive oxygen species (ROS) producers. We found that oxyresveratrol inhibited the O2− production induced upon stimulation of monocytes with β-glucan, a well known fungal immune cell activator. We then investigated whether the inclusion of oxyresveratrol into nanoparticles could modulate its effects on O2− release. We synthesized poly(lactic-co-glycolic acid) (PLGA) nanoparticles, and we assessed their effects on monocytes. We found that empty PLGA nanoparticles induced O2− production by resting monocytes and enhanced the formation of this radical in β-glucan-stimulated monocytes. Interestingly, the insertion of oxyresveratrol into PLGA nanoparticles significantly inhibited the O2− production elicited by unloaded nanoparticles in resting monocytes as well as the synergistic effect of nanoparticles and β-glucan. Our results indicate that oxyresveratrol is able to inhibit ROS production by activated monocytes, and its inclusion into PLGA nanoparticles mitigates the oxidative effects due to the interaction between these nanoparticles and resting monocytes. Moreover, oxyresveratrol can contrast the synergistic effects of nanoparticles with fungal agents that could be present in the patient tissues. Therefore, oxyresveratrol is a natural compound able to make PLGA nanoparticles more biocompatible.

show abstract

Section: Discussionmentioning

confidence: 99%

Oxyresveratrol-Loaded PLGA Nanoparticles Inhibit Oxygen Free Radical Production by Human Monocytes: Role in Nanoparticle Biocompatibility

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Finally, a nanoparticle unable to activate immune cells and, therefore, generally considered biocompatible, could instead enhance the pro-inflammatory effect of some microorganisms or their derivatives [ 18 , 43 , 44 , 45 ] through a cooperative event named “cell priming” [ 46 , 47 ]. This implies that, if this apparently harmless nanoparticle is administered to the patient in the presence of other agents such as pathogenic fungi, bacteria, or viruses, it might cause unwanted dangerous effects as it can induce a hyper-responsiveness of leukocytes to the above-mentioned agents.…”

Section: Introductionmentioning

confidence: 99%

Effects of Magnetic Nanoparticles on the Functional Activity of Human Monocytes and Dendritic Cells

Donini

Pettinella

Zanella

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

The use of nanoparticles in medicine is sometimes hampered by their potential to activate immune cells, eliciting inflammation or allergy. We investigated whether magnetic nanoparticles (MNPs) or biomimetic magnetic nanoparticles (BMNPs) affect relevant activities of human monocytes. We found that the nanoparticles neither elicited the production of pro-inflammatory mediators IL-6 and TNFα by resting monocytes (when BMNP dose < 300 μg/mL) nor enhanced their secretion induced by R848, a molecule engaging virus-recognizing receptors, or bacterial lipopolysaccharide (LPS). MNPs and BMNPs neither induced the generation of reactive oxygen species (ROS), nor affected the ROS production elicited by the NADPH oxidase activator phorbol myristate acetate (PMA) or the fungal derivative β-glucan. BMNPs, but not MNPs, caused an up-regulation of the maturation markers CD80, CD83, and CD86 in immature monocyte-derived dendritic cells (DCs), whereas both nanoparticles did not affect the LPS-induced expression of these markers. Moreover, the nanoparticles were greedily ingested by monocytes and DCs without altering their viability. Therefore, these nanoparticles are candidates for medical applications because they do not activate pro-inflammatory activities of monocytes. Furthermore, their ability to stimulate DC maturation could be used for the design of vaccines. Moreover, harmlessly engulfed nanoparticles could be vehicles to carry molecules inside the immune cells to regulate the immune response.

show abstract

“…In this work, we explore the use of ALD to stabilize and potentially functionalize solution-processed thin films of Si NPs (Figure ). Despite the recently highlighted potential of Si NP films for a wide range of applications, like photovoltaics, thin-film transistors, , and plasmonics, investigations of the impact of an ALD infilling on their stability and physicochemical properties are still in a very initial stage. , In a previous work, it has been found that encapsulation of FETs based on Si NP films with Al 2 O 3 deposited with ALD led to a suppression of hysteresis in the transistor characteristics . For our studies, we prepared films of randomly distributed Si NPs with ultrashort surface ligands (Si–H termination) using wet chemistry and spray-coating and then used ALD to infill the films with Al 2 O 3 .…”

Section: Introductionmentioning

confidence: 99%

Silicon Nanoparticle Films Infilled with Al₂O₃ Using Atomic Layer Deposition for Photosensor, Light Emission, and Photovoltaic Applications

Botas

Leitão

Falcão

et al. 2020

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Solution-processed thin films of crystalline silicon nanoparticles (Si NPs) have a great potential for a wide variety of electronic and optoelectronic applications. However, such films are inherently unstable due to their huge surface-to-volume ratios and high surface energies, making them prone to degradation associated with spontaneous oxidation in ambient conditions. In this work, we explore the use of atomic layer deposition (ALD) as a means to stabilize and potentially functionalize solutionprocessed thin films of Si NPs for (opto)electronics, e.g., thinfilm transistors, photosensors, light-emitting devices, and photovoltaics. We prepared films of randomly distributed Si NPs with ultrashort surface ligands (Si−H termination) using wet chemistry and spray-coating and then use ALD to infill the films with Al 2 O 3 . Through microscopy and optical structural/morphological analysis, we demonstrate the achievability of ALD infilling of films of Si NPs and probe the stability of these films against oxidation. Moreover, we show that the ALD infilling leads to changes in the light emission properties of the Si NP films, including a relative quenching of disorder-related emission features and variations in surfacerelated dielectric confinement effects. Our studies reveal ALD as a relevant technique toward manufacturing de facto robust, functional nanomaterials based on Si NPs and on nanoscale silicon materials more generally.

show abstract

TiO₂-coated luminescent porous silicon micro-particles as a promising system for nanomedicine

Abstract: Porous silicon (pSi), a sponge-like material, was coated by ALD with a TiO2 layer to stabilize photoluminescence in biological media. In vitro results open the way to promising applications in nanomedicine.

Cited by 15 publications

References 42 publications

Oxyresveratrol-Loaded PLGA Nanoparticles Inhibit Oxygen Free Radical Production by Human Monocytes: Role in Nanoparticle Biocompatibility

Oxyresveratrol-Loaded PLGA Nanoparticles Inhibit Oxygen Free Radical Production by Human Monocytes: Role in Nanoparticle Biocompatibility

Effects of Magnetic Nanoparticles on the Functional Activity of Human Monocytes and Dendritic Cells

Silicon Nanoparticle Films Infilled with Al₂O₃ Using Atomic Layer Deposition for Photosensor, Light Emission, and Photovoltaic Applications

Contact Info

Product

Resources

About

TiO2-coated luminescent porous silicon micro-particles as a promising system for nanomedicine

Abstract: Porous silicon (pSi), a sponge-like material, was coated by ALD with a TiO2 layer to stabilize photoluminescence in biological media. In vitro results open the way to promising applications in nanomedicine.

Cited by 15 publications

References 42 publications

Oxyresveratrol-Loaded PLGA Nanoparticles Inhibit Oxygen Free Radical Production by Human Monocytes: Role in Nanoparticle Biocompatibility

Oxyresveratrol-Loaded PLGA Nanoparticles Inhibit Oxygen Free Radical Production by Human Monocytes: Role in Nanoparticle Biocompatibility

Effects of Magnetic Nanoparticles on the Functional Activity of Human Monocytes and Dendritic Cells

Silicon Nanoparticle Films Infilled with Al2O3 Using Atomic Layer Deposition for Photosensor, Light Emission, and Photovoltaic Applications

Contact Info

Product

Resources

About

TiO₂-coated luminescent porous silicon micro-particles as a promising system for nanomedicine

Silicon Nanoparticle Films Infilled with Al₂O₃ Using Atomic Layer Deposition for Photosensor, Light Emission, and Photovoltaic Applications