Tintelnotia destructans: Ein neuer Feind vor dem Tore

Abstract

Tintelnotia destructans is a fungal species described for the first time in 2016, which can cause infections of the nails and of the cornea. We describe the second known case worldwide of Tintelnotia destructans-associated keratitis and its therapy. A good sensitivity for amphotericin B and voriconazole was demonstrated in the resistogram for the first time and the successful clinical course was confirmed. The present case study also shows the importance of intensive diagnostics in atypical microbial keratitis.

New Antimycotics in the Pipeline – For Ophthalmology Too?

“…Whereas microbiological laboratories can provide confirmed identification of bacteria easily, rapidly and reliably, the same procedure can be difficult and lengthy when fungi are involved. An extreme example of this was the detection of Tintelnotia destructans, which required > 3 years at the European CBS-KNAW Fungal Biodiversity Centre in Utrecht [1], whereby the procedure was later accelerated [2,3]. The recommendation is therefore to send the excidate (scrape hard with metal spatula!)…”

“…Bevor der oben vorgeschlagene Kontakt mit dem Hersteller aufgenommen wird, sollten die in ▶ Tab. 2 [33,34], aber Natamycin (Pimaricin) mit 675,75 g/mol und die Echinocandine [35]. In [36] sind die MG dargestellt und weitere Therapiehinweise aufgeführt.…”