Tinospora cordifolia protects against inflammation associated anemia by modulating inflammatory cytokines and hepcidin expression in male Wistar rats

Ghatpande, Niraj S.; Misar, Ashwini; Waghole, Ravindra Jagannath; Jadhav, Sachin; Kulkarni, Purushottam

doi:10.1038/s41598-019-47458-0

Cited by 36 publications

(24 citation statements)

References 23 publications

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“…Furthermore, the aqueous extract of T. cordifolia was also reported to be significantly reduced the production of NO and downregulated gene expression of TNF-α and COX-2. Besides this, the extract also inhibited the gene expression of toll-like receptor 4 [60], which is an important regulator of wound inflammation [61]. However, the aqueous extract of T. cordifolia only significantly inhibited IL-β at higher concentrations of 250-500 μg/ml.…”

Section: Discussionmentioning

confidence: 94%

The Potential Role of Genus Tinospora in Wound Healing: A Review

Fernandez¹,

Shivashekaregowda²,

Yow³

2021

Int J Pharm Pharm Sci

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Genus Tinospora has been used in traditional medicine throughout various parts of Asia, particularly in India, China, Thailand, Malaysia and Cambodia. Its ethnomedicinal uses include treatment for fever, cold, oral ulcer, headaches, diarrhoea, diabetes, digestive disorder and rheumatoid arthritis. Some of its ethnomedicinal uses have been justified via scientific studies, include antidiabetic, antioxidant, anti-inflammatory and antimicrobial effects. Recently, several studies have been initiated to investigate the role of Tinospora species in wound healing. This comprehensive review used updated information obtained from systematic literature search using PubMed, Scopus, Science Direct and Google Scholar, to assess the wound healing properties of eleven major Tinospora species namely, T. cordifolia, T. crispa, T. sagittata, T. sinensis, T. bakis, T. craveniana, T. tuberculata, T. capillipes, T. rumphii, T. smilacina, and T. baenzigeri. The information obtained revealed that only T. cordifolia and T. crispa have been reported on its wound-healing abilities. Studies demonstrated that T. cordifolia is associated with early re-epithelisation, enhanced tensile strength, increased granulation tissues and increased collagen contents. Whereas T. crispa is reported with wound healing activity through the elevated antioxidant enzymes and inflammation phase. Nevertheless, there is limited evidence on phytochemical constituents from plant extracts that contribute to the wound healing process and their underlying mechanisms. This review deduced the potential gaps for future research aiming to study the genus Tinospora as a potential wound healing agent.

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Section: Discussionmentioning

confidence: 94%

The Potential Role of Genus Tinospora in Wound Healing: A Review

Fernandez¹,

Shivashekaregowda²,

Yow³

2021

Int J Pharm Pharm Sci

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“…Active components of WS (withanone and withaferin A) and AR (shatavarin-IV) also inhibited production of IL-6 in in vitro system. It has also been reported that aqueous extract of TC protects against in ammation associated anaemia by modulating hepcidin expression, IL-6 and other pro-in ammatory cytokine cascade 63 .There is a clinical evidence of COVID-19 from Wuhan, China indicating that the immunocompromised patients are at high risk of developing fatal respiratory syndrome 71 . In view of this, immunomodulating drugs are being considered bene cial for COVID-19 management 72 .…”

Section: Discussionmentioning

confidence: 99%

“…This was supported by clinical observations of reduction in haemoglobin and increased erythrocyte sedimentation rate. This induces hypoxia leading to organ failure 62 .A systematic in vivo study of TC extract showed signi cant increase in levels of haemoglobin and erythrocyte count to maintain systemic iron homeostasis 63 . WS showed prophylactic effect in pulmonary hypertension characterised by hypoxia and in ammation 64 .…”

Section: Discussionmentioning

confidence: 99%

Ayurveda botanicals in COVID-19 management: An in silico- multitarget approach

Borse

Joshi

Saggam

et al. 2020

Preprint

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The Coronavirus disease (COVID-19) caused by the virus SARS-CoV-2 has become a global pandemic in a very short time span. Currently, there is no specific treatment or vaccine to counter this highly contagiousdisease. Presently, existing anti-virals and disease-modifying agents are being repurposed to manage COVID-19. There is an urgent need to find a specific cure for the disease and global efforts are directed at developing SARS-CoV-2 specific anti-viralsand immunomodulators.The objective of this study is to explore the immunomodulatory and anti-SARS-CoV-2 potential of key phytoconstituents from Ayurveda based Rasayana drugs, Withania somnifera (Ashwagandha), Tinospora cordifolia (Guduchi) and Asparagus racemosus (Shatavari) using in silico approaches like network pharmacology, and molecular docking. The SWISS-ADME tool was used to predict the pharmacokinetic and pharmacodynamic (PK-PD) interactions and drug likeliness potential. Using these approaches we propose a library of phytomolecules with potential to be developed as phytopharmaceuticals for COVID 19 management.The plant extracts were prepared as per Ayurvedic procedures and a total of 31 phytoconstituents were identified using HPLC and MS studies. The network pharmacology model shows that these phytoconstituents possess the potential to modulate several immune pathways. Amongst the three botanicalsWithania somnifera was found to be the most potent immunomodulator through its potential to modulate T cell differentiation, NK cell cytotoxicity as well as T cell, B cell and NOD-like receptor signalling pathways.Molecular docking studies showed thatseveral phytoconstituents possess good affinity for the Spike protein, Main Protease and RNA dependent RNA polymerase of SARS-CoV-2 suggesting their application for the termination of viral life cycle. Further, predictive tools indicate that there would beneficial herb-drug pharmacokinetic-pharmacodynamic interactions with concomitantly administered drug therapy. We thus make a compelling case to evaluate the potential of these Rasayana botanicals in the management of COVID-19 following rigorous experimental validation.

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“…NS seed oil suppressed the viral burden to undetectable levels within ten days of intraperitoneal (i.p.) injection of black seed oil in a murine model [ 136 ].…”

Section: Herbs Considered Usable For the Treatment Of Covid-19mentioning

confidence: 99%

“…The strongest candidates for COVID-19 treatment thus appear to be nigellidine and α-hederin. Further studies are needed to confirm the medical value of Nigella sativa and to advocate its usage as a preventative measure against coronavirus infection [ 136 ].…”

Section: Herbs Considered Usable For the Treatment Of Covid-19mentioning

confidence: 99%

Nutraceuticals and Herbs in Reducing the Risk and Improving the Treatment of COVID-19 by Targeting SARS-CoV-2

Tagde¹,

Tagde²,

Tagde³

et al. 2021

Biomedicines

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The worldwide transmission of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a deadly or devastating disease is known to affect thousands of people every day, many of them dying all over the planet. The main reason for the massive effect of COVID-19 on society is its unpredictable spread, which does not allow for proper planning or management of this disease. Antibiotics, antivirals, and other prescription drugs, necessary and used in therapy, obviously have side effects (minor or significant) on the affected person, there are still not clear enough studies to elucidate their combined effect in this specific treatment, and existing protocols are sometimes unclear and uncertain. In contrast, it has been found that nutraceuticals, supplements, and various herbs can be effective in reducing the chances of SARS-CoV-2 infection, but also in alleviating COVID-19 symptoms. However, not enough specific details are yet available, and precise scientific studies to validate the approved benefits of natural food additives, probiotics, herbs, and nutraceuticals will need to be standardized according to current regulations. These alternative treatments may not have a direct effect on the virus or reduce the risk of infection with it, but these products certainly stimulate the human immune system so that the body is better prepared to fight the disease. This paper aims at a specialized literary foray precisely in the field of these “cures” that can provide real revelations in the therapy of coronavirus infection

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Tinospora cordifolia protects against inflammation associated anemia by modulating inflammatory cytokines and hepcidin expression in male Wistar rats

Cited by 36 publications

References 23 publications

The Potential Role of Genus Tinospora in Wound Healing: A Review

The Potential Role of Genus Tinospora in Wound Healing: A Review

Ayurveda botanicals in COVID-19 management: An in silico- multitarget approach

Nutraceuticals and Herbs in Reducing the Risk and Improving the Treatment of COVID-19 by Targeting SARS-CoV-2

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