Tinnitus-related neural activity: Theories of generation, propagation, and centralization

Noreña, Arnaud; Farley, Brandon J.

doi:10.1016/j.heares.2012.09.010

Cited by 196 publications

(151 citation statements)

References 130 publications

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“…These results are similar to results from previous studies that have reported on high-pitched tinnitus caused by acoustic trauma [21,22] . The auditory neurons responsible for the tinnitus could fire more than normal because of reduced lateral inhibition at the edge of the characteristic frequency of the damaged hair cells [23,24] . Given this theory, and the fact that noise usually causes a 4 kHz dip in the audiogram, the average perceived frequency in noise-induced tinnitus of 5.50 kHz is understandable.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Long-Term Outcome of Intratympanic Dexamethasone Therapy between Acute Noise-Induced Tinnitus and Acute Idiopathic Tinnitus

Shim

Lee²,

An³

et al. 2017

Int Adv Otol

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OBJECTIVE:To compare the long-term outcomes of acute noise-induced tinnitus (ANT) and acute idiopathic tinnitus (AIT) to intratympanic dexamethasone (ITD) therapy. MATERIALS and METHODS:Patients treated for tinnitus occurring immediately after noise exposure comprised the ANT group (n=20) and patients treated for idiopathic tinnitus comprised the AIT group (n=39). All patients were treated with ITD within 3 months of the onset of tinnitus. Quantitative assessment of the improvement in tinnitus using questionnaires and changes in hearing thresholds were compared between the two groups. RESULTS:Mean follow-up durations were 75.90±69.83 weeks in the ANT group and 93.41±101.43 weeks in the AIT group. Patients with ANT were younger in age than those with AIT (38.30±18.28 vs. 53.56±14.08, p=0.00) and were predominately male (Male: Female, M:F 13:7 vs. 13:26, p=0.02, respectively). The subjective tinnitus loudness, time of tinnitus awareness, and Tinnitus Handicap Inventory score improved in both groups, although the changes in these parameters were not significantly different between the groups. The cure and overall improvement rates of the ANT group were and 10.00% and 25.00%, respectively. The cure and overall improvement rates of the AIT groups were 25.64% and 35.90%, respectively and there were no significant differences between the two groups in terms of the cure and overall improvement rates (p=0.19 and 0.40, respectively). CONCLUSION:The long-term outcome in terms of control of tinnitus with ITD in the ANT group was similar to that in the AIT group. Thus, ITD injection may be a useful treatment option for acute tinnitus caused by noise trauma.

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Section: Discussionmentioning

confidence: 99%

“…Indeed, many cases with improvement in tinnitus were not associated with an audiological response. This finding could be explained if the pathophysiology of tinnitus depends more on plastic changes in the central auditory system rather than on the degree of cochlear damage [23,24,31,32] .…”

Section: Discussionmentioning

confidence: 99%

Comparison of Long-Term Outcome of Intratympanic Dexamethasone Therapy between Acute Noise-Induced Tinnitus and Acute Idiopathic Tinnitus

Shim

Lee²,

An³

et al. 2017

Int Adv Otol

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“…One of the most reliable hypotheses concerning the origin of tinnitus regards changes in the central nervous system induced by sensory deprivation linked to cochlear damage, even when it is subtle and hearing loss is not visible in the audiogram 15 . Our patient presented a subtle cochlear dysfunction demonstrated by the mild high-frequency sensorineural hearing loss in the right ear, the reduction in amplitude of otoacoustic emissions at the low and high frequencies, and the absence of retrocochlear involvement in auditory evoked potentials.…”

Section: Discussionmentioning

confidence: 99%

The effect of a gluten-free diet on a patient complaining of severe tinnitus

Barozzi¹,

Bo²,

Cesarani

2013

The International Tinnitus Journal

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We report a case of a patient complaining of severe high pitched tinnitus, dizziness, joint/muscle pain and gastrointestinal symptoms. A mild high-frequency sensorineural hearing loss of cochlear origin was diagnosed in the ear where tinnitus was present. The patient reported a considerable decrease in tinnitus and other symptoms with a gluten-free diet. Gluten sensitivity may have contributed to the pathogenesis of tinnitus in our patient; further research is needed to determine the exact role of gluten in this condition.

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“…It seems as if tinnitus is caused by changes in the central nervous system, due to sensory deprivation 3 .…”

Section: Introductionmentioning

confidence: 99%

A Randomized, Placebo-Controlled, Double-Blind, Parallel Groups Study Evaluating the Performance and Safety of a Steady State Coherent Biomodulator Patch in the Treatment of Subjective Tinnitus

Ahnblad¹,

Nordkvist²

2017

The International Tinnitus Journal

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Objective: The objectives of this study were to evaluate the performance and safety of an innovative passive light photon driven microscopic biomodulator patch as an alternative medical device for tinnitus relief. Materials and Methods: Eighty-two (82) patients were randomized to receive either an active (biomodulator) patch or a placebo patch, for a 3-week treatment period. Patch performance (evaluated with questionnaires related to tinnitus and quality-of-life) and safety were assessed after 3 weeks of treatment (Week 3) and at a follow-up visit 4-weeks after end of treatment (Week 7). Results: The biomodulator patch was safe and well-tolerated and was efficacious, with significant difference (p < 0.05) between the groups at Week 7; active patch had 30% responders compared to 10% for placebo, measured as a decrease from baseline in at least 2 points in tinnitus annoyance visual analogue scale (VAS, 0-10). Tinnitus handicap inventory (THI, 0-100) improved by mean -16 points significantly (p = 0.0005) for the active responder group, but with no statistically significant changes for the placebo group or between the groups. Well-being questionnaire also improved for the active responder group, but not statistically significant. The placebo responder group did not improve in well-being. Other tinnitus related symptoms did not show significant changes. There was no statistically significant difference in performance between the active (biomodulator) and placebo groups directly at the end of treatment (Week 3). Conclusion: In a cost-risk-benefit rationale according to this study it can be reasonable to recommend the biomodulator patch for treatment of tinnitus. Improvements were shown at Week 7 (4 weeks after the end of treatment period).

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Tinnitus-related neural activity: Theories of generation, propagation, and centralization

Cited by 196 publications

References 130 publications

Comparison of Long-Term Outcome of Intratympanic Dexamethasone Therapy between Acute Noise-Induced Tinnitus and Acute Idiopathic Tinnitus

Comparison of Long-Term Outcome of Intratympanic Dexamethasone Therapy between Acute Noise-Induced Tinnitus and Acute Idiopathic Tinnitus

The effect of a gluten-free diet on a patient complaining of severe tinnitus

A Randomized, Placebo-Controlled, Double-Blind, Parallel Groups Study Evaluating the Performance and Safety of a Steady State Coherent Biomodulator Patch in the Treatment of Subjective Tinnitus

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