Tinnitus and Patterns of Hearing Loss

Tan, Chong-Tin; Lecluyse, Wendy; McFerran, Don; Meddis, Ray

doi:10.1007/s10162-013-0371-6

Cited by 53 publications

(45 citation statements)

References 21 publications

(32 reference statements)

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“…Tan et al [2013] demonstrated that patients with chronic tinnitus tended to experience high-frequency hearing loss, better frequency selectivity and compression. This difference may be caused by the different mechanisms between acute and chronic tinnitus.…”

Section: Discussionmentioning

confidence: 99%

Acute-Onset Tinnitus Is Associated with Contralateral Hearing in Sudden Deafness

et al. 2015

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Objective: We aimed to evaluate the prognostic factors for acute-onset tinnitus associated with unilateral idiopathic sudden sensorineural hearing loss (ISSNHL) and to assess the relationship between these factors and the final recovery. Methods: A total of 770 patients with unilateral ISSNHL were enrolled retrospectively and their medical records reviewed. Patients were classified into two groups according to the presence of acute-onset tinnitus at the initial examination. Patient characteristics and the results of pure-tone audiometry were compared between the two groups initially and 3 months later. Results: A total of 70.9% (n = 546) of patients had tinnitus initially. There was no significant difference in the mean hearing thresholds of the affected ear irrespective of accompanying tinnitus. In contrast, patients with tinnitus in the affected ear tended to have significantly better mean hearing thresholds in the nonaffected ear (p < 0.05). The logistic regression analysis revealed that better mean hearing thresholds in the nonaffected ear were associated with tinnitus occurrence (p < 0.05). Better hearing thresholds in the nonaffected ear, younger age, absence of dizziness, low-tone hearing loss, and combined intratympanic dexamethasone injection were associated with full recovery (p < 0.05). However, tinnitus was not an independent risk factor for full recovery. Conclusion: Better contralateral hearing was associated with both an increased incidence of concurrent tinnitus and a better final recovery. However, tinnitus was not related to full recovery.

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Section: Discussionmentioning

confidence: 99%

Acute-Onset Tinnitus Is Associated with Contralateral Hearing in Sudden Deafness

et al. 2015

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“…Within a run, the masker level was varied to determine the masking threshold for the probe. Between runs, the masker frequency was changed randomly across the following values, 0.5, 0.7, 0.9, 1, 1.1, 1.2, 1.3 and 1.6 times the probe frequency and resulted in an iso-forward masking contour (IFMC; Meddis et al, 2010;Lecluyse et al, 2013;Tan et al, 2013). IFMCs were generated for probe frequencies 0.25, 0.5, 1, 2, 4, and 6 kHz.…”

Section: General Principlesmentioning

confidence: 99%

“…The development and assessment of the measurement procedures have been described elsewhere Tan et al, 2013). Their aim is to generate an auditory profile that summarizes basic aspects of auditory functioning while also being simple enough to be used in the context of computer modelling.…”

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confidence: 99%

Hearing dummies: Individualized computer models of hearing impairment

Panda

Lecluyse

Tan

et al. 2014

International Journal of Audiology

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“…The high-threshold ANFs most vulnerable to damage by noise exposure (Furman et al, 2013) or to deterioration with aging (Sergeyenko et al, 2013) are those with high frequency tuning (Kujawa and Liberman, 2009), which is consistent with the percepts reported in audiometrically normal tinnitus (Roberts et al, 2008;Schaette and McAlpine, 2011). Cochlear factors may also explain why not all individuals with high frequency hearing loss detected by the audiogram develop tinnitus (Tan et al, 2013). High threshold ANFs with high frequency tuning could be better preserved in such individuals, although this question has not been extensively studied.…”

Section: Introductionmentioning

confidence: 99%

Evidence for differential modulation of primary and nonprimary auditory cortex by forward masking in tinnitus

et al. 2015

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It has been proposed that tinnitus is generated by aberrant neural activity that develops among neurons in tonotopic of regions of primary auditory cortex (A1) affected by hearing loss, which is also the frequency region where tinnitus percepts localize (Eggermont and Roberts 2004; Roberts et al., 2010, 2013). These models suggest (1) that differences between tinnitus and control groups of similar age and audiometric function should depend on whether A1 is probed in tinnitus frequency region (TFR) or below it, and (2) that brain responses evoked from A1 should track changes in the tinnitus percept when residual inhibition (RI) is induced by forward masking. We tested these predictions by measuring (128-channel EEG) the sound-evoked 40-Hz auditory steady-state response (ASSR) known to localize tonotopically to neural sources in A1. For comparison the N1 transient response localizing to distributed neural sources in nonprimary cortex (A2) was also studied. When tested under baseline conditions where tinnitus subjects would have heard their tinnitus, ASSR responses were larger in a tinnitus group than in controls when evoked by 500 Hz probes while the reverse was true for tinnitus and control groups tested with 5 kHz probes, confirming frequency-dependent group differences in this measure. On subsequent trials where RI was induced by masking (narrow band noise centered at 5 kHz), ASSR amplitude increased in the tinnitus group probed at 5 kHz but not in the tinnitus group probed at 500 Hz. When collapsed into a single sample tinnitus subjects reporting comparatively greater RI depth and duration showed comparatively larger ASSR increases after masking regardless of probe frequency. Effects of masking on ASSR amplitude in the control groups were completely reversed from those in the tinnitus groups, with no change seen to 5 kHz probes but ASSR increases to 500 Hz probes even though the masking sound contained no energy at 500 Hz (an "off-frequency" masking effect). In contrast to these findings for the ASSR, N1 amplitude was larger in tinnitus than control groups at both probe frequencies under baseline conditions, decreased after masking in all conditions, and did not relate to RI. These results suggest that aberrant neural activity occurring in the TFR of A1 underlies tinnitus and its modulation during RI. They indicate further that while neural changes occur in A2 in tinnitus, these changes do not reflect the tinnitus percept. Models for tinnitus and forward masking are described that integrate these findings within a common framework.

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Tinnitus and Patterns of Hearing Loss

Cited by 53 publications

References 21 publications

Acute-Onset Tinnitus Is Associated with Contralateral Hearing in Sudden Deafness

Acute-Onset Tinnitus Is Associated with Contralateral Hearing in Sudden Deafness

Hearing dummies: Individualized computer models of hearing impairment

Evidence for differential modulation of primary and nonprimary auditory cortex by forward masking in tinnitus

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