“…This plasticity has been demonstrated in a wide range of animal models, using either mechanically, acoustically, or drug-induced cochlear lesions (Kaltenbach et al, 2000;Seki and Eggermont, 2003;Kaltenbach et al, 2004;Ma et al, 2006;Brozoski et al, 2007;Bauer et al, 2008;Dong et al, 2009Dong et al, , 2010). Hyperactivity has been suggested to be involved in the generation of tinnitus, an auditory phantom perception (Brozoski et al, 2002;Kaltenbach et al, 2004;Bauer et al, 2008). This hypothesis is supported by the fact that the hyperactivity seems restricted to tonotopic regions broadly corresponding to the area of hearing loss as shown in cochlear nucleus (CN), the central nucleus of the inferior colliculus (CNIC), and the auditory cortex (Kaltenbach et al, 2000;Komiya and Eggermont, 2000;Seki and Eggermont, 2003;Ma et al, 2006;Dong et al, 2009;) and the observation in human studies that there is a strong correlation between the tinnitus pitch and the hearing loss frequencies (MĂŒhlnickel et al, 1998;Norena et al, 2002;Eggermont and Roberts, 2004).…”