Tinnitus

Langguth, Berthold; Ridder, Dirk De

doi:10.1016/b978-0-444-53497-2.00036-x

Cited by 39 publications

(21 citation statements)

References 183 publications

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“…This might be an indicator for reduced adaptive potential of the auditory cortex in tinnitus patients and—if confirmed by further studies—has important implications for understanding the pathophysiological underpinnings of tinnitus. Moreover, the reduced variability might represent a potential therapeutic target for neuromodulatory treatment approaches, for example, by auditory [45] or brain stimulation [46]. …”

Section: Discussionmentioning

confidence: 99%

Reduced Variability of Auditory Alpha Activity in Chronic Tinnitus

et al. 2014

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Subjective tinnitus is characterized by the conscious perception of a phantom sound which is usually more prominent under silence. Resting state recordings without any auditory stimulation demonstrated a decrease of cortical alpha activity in temporal areas of subjects with an ongoing tinnitus perception. This is often interpreted as an indicator for enhanced excitability of the auditory cortex in tinnitus. In this study we want to further investigate this effect by analysing the moment-to-moment variability of the alpha activity in temporal areas. Magnetoencephalographic resting state recordings of 21 tinnitus subjects and 21 healthy controls were analysed with respect to the mean and the variability of spectral power in the alpha frequency band over temporal areas. A significant decrease of auditory alpha activity was detected for the low alpha frequency band (8–10 Hz) but not for the upper alpha band (10–12 Hz). Furthermore, we found a significant decrease of alpha variability for the tinnitus group. This result was significant for the lower alpha frequency range and not significant for the upper alpha frequencies. Tinnitus subjects with a longer history of tinnitus showed less variability of their auditory alpha activity which might be an indicator for reduced adaptability of the auditory cortex in chronic tinnitus.

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Section: Discussionmentioning

confidence: 99%

Reduced Variability of Auditory Alpha Activity in Chronic Tinnitus

et al. 2014

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“…Müller et al [40] used external stimulation by applying repetitive TMS (rTMS), a method which has been frequently explored as potential clinical tool, however with mixed outcomes [52]. By measuring MEG, the authors revealed that the tinnitus relief after applying rTMS was associated with an increase of alpha power in auditory cortex.…”

Section: Auditory Domainmentioning

confidence: 99%

The role of alpha oscillations for illusory perception

Lange¹,

Keil²,

Schnitzler³

et al. 2014

Behavioural Brain Research

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“…Although tDCS mechanisms are only partially understood (Stagg and Nitsche, 2011), numerous studies have evaluated the effects of tDCS in the treatment of several neurological and psychiatric diseases, including depression (Kalu et al, 2012), tinnitus (Langguth and De Ridder, 2013) and Parkinson’s disease (Boggio et al, 2006). In particular, anodal stimulation of the left dorsolateral prefrontal cortex (DLPFC) was shown to improve performance of several cognitive abilities in healthy subjects (Iyer et al, 2005; Fiori et al, 2011) and in patients with stroke (Kang et al, 2009) or Alzheimer’s disease (Ferrucci et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients

Cavaliere

Aiello

Perri³

et al. 2016

Front. Cell. Neurosci.

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Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising evidences about its possible role in the treatment of many neurological and psychiatric conditions exist, no evidences exist about brain functional connectivity substrates underlying tDCS response. We retrospectively evaluated resting state functional Magnetic Resonance Imaging (fMRI) of 16 sub-acute and chronic MCS patients (6 tDCS responders) who successively received a single left dorsolateral prefrontal cortex (DLPFC) tDCS in a double-blind randomized cross-over trial. A seed-based approach for regions of left extrinsic control network (ECN) and default-mode network (DMN) was performed. tDCS responders showed an increased left intra-network connectivity for regions co-activated with left DLPFC, and significantly with left inferior frontal gyrus. Non-responders (NR) MCS patients showed an increased connectivity between left DLPFC and midline cortical structures, including anterior cingulate cortex and precuneus. Our findings suggest that a prior high connectivity with regions belonging to ECN can facilitate transitory recovery of consciousness in a subgroup of MCS patients that underwent tDCS treatment. Therefore, resting state-fMRI could be very valuable in detecting the neuronal conditions necessary for tDCS to improve behavior in MCS.

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Tinnitus

Cited by 39 publications

References 183 publications

Reduced Variability of Auditory Alpha Activity in Chronic Tinnitus

Reduced Variability of Auditory Alpha Activity in Chronic Tinnitus

The role of alpha oscillations for illusory perception

Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients

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