Tinidazole inhibitory and cidal activity against anaerobic periodontal pathogens

Alou, Luís; Giménez, Marı́a José; Manso, Francisco Nodar; Sevillano, David; Torrico, M.; González, Natalia; Granizo, Juan-José; Bascones, A; Prieto, J.; Maestre, Juan Ramón; Aguilar, Lorenzo

doi:10.1016/j.ijantimicag.2008.10.012

Cited by 13 publications

(19 citation statements)

References 21 publications

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“…Combinations of b-lactams with b-lactamase inhibitors, as well as carbapenems, were found to exhibit the highest antimicrobial activity against Prevotella spp. overall, whereas some studies have highlighted the emergence of metronidazole resistance [54,196,[212][213][214][215][216][217]. However, susceptibility profiles vary significantly by bacterial species, geographic origin and source of isolation.…”

Section: Antimicrobial Susceptibility and Resistance Mechanisms Of Prevmentioning

confidence: 99%

“…may cause clinical failures when patients are treated with penicillins [221]. Morevover, the presence of excreted b-lactamases in body tissues or fluids may have ecological and therapeutic consequences, since it may protect b-lactamase-negative pathogens from amoxicillin treatment [213]. In Prevotella, acquired resistance to b-lactams is mainly due to the production of a class A b-lactamase, able to hydrolyze penicillins and cephalosporins [124,211,221,222].…”

Section: Antimicrobial Susceptibility and Resistance Mechanisms Of Prevmentioning

confidence: 99%

“…The prevalence of resistance to tetracycline among clinical isolates of Prevotella spp. varies according to the study [213,[229][230][231][232][233][234]. Gad et al reported a resistance rate to doxycycline of 25% in Prevotella spp.…”

Section: Antimicrobial Susceptibility and Resistance Mechanisms Of Prevmentioning

confidence: 99%

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New Insights into Prevotella Diversity and Medical Microbiology

Alauzet¹,

Marchandin

Lozniewski³

2010

Future Microbiol.

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In light of recent studies based on cultivation-independent methods, it appears that the diversity of Prevotella in human microbiota is greater than was previously assumed from cultivation-based studies, and that the implication of these bacteria in several human diseases was unrecognized. While some Prevotella taxa were found during opportunistic infections, changes in Prevotella abundance and diversity were discovered during dysbiosis-associated diseases. As member of the microbiota, Prevotella may also be considered as a reservoir for resistance genes. Greater knowledge on Prevotella diversity, as well as new insights into its pathogenic potential and implication in dysbiosis are expected from the use of human microbe identification microarrays, from whole-genome sequence analyse, and from the NIH Human Microbiome Project data. New approaches, including molecular-based methods, could contribute to improve the diagnosis of Prevotella infections.

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Section: Antimicrobial Susceptibility and Resistance Mechanisms Of Prevmentioning

confidence: 99%

Section: Antimicrobial Susceptibility and Resistance Mechanisms Of Prevmentioning

confidence: 99%

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New Insights into Prevotella Diversity and Medical Microbiology

Alauzet¹,

Marchandin

Lozniewski³

2010

Future Microbiol.

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“…With respect to periodontal pathogens, in a previous in vitro study, 10 the presence of β‐lactamases rendered amoxicillin inactive (not reducing the initial mixed inocula), because β‐lactamases produced by Prevotella spp. and Fusobacterium nucleatum protected β‐lactamase–negative amoxicillin‐susceptible strains ( Streptococcus spp.…”

mentioning

confidence: 94%

“…and Veillonella spp.). In contrast, amoxicillin plus tinidazole showed bactericidal activity; tinidazole countered the indirect pathogen effect, restoring amoxicillin activity against Streptococcus spp 10 . The role of tinidazole, in combination with antibiotics theoretically not influenced by β‐lactamase activity, remains to be explored.…”

mentioning

confidence: 99%

In Vitro Killing Activity of Crevicular Concentrations of Tinidazole Plus Common Oral Antibiotics Against High‐Density Mixed Inocula of Periodontal Pathogens in Strict Anaerobic Conditions

Alou

Giménez

Manso

et al. 2010

Journal of Periodontology

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Formulation and evaluation of in situ forming PLA implant containing tinidazole for the treatment of periodontitis

Qin¹,

Yuan²,

Li³

et al. 2012

J Biomed Mater Res

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Periodontitis is caused by periodontopathic bacteria and antibacterial agents are placed in a periodontal pocket with the intention of enhancing the local effect. To maximize the therapeutic effects while reducing the adverse effects, tinidazole was delivered by in situ forming system. One approach for reducing burst release rate was to testify in situ forming effect. The effect of 0%-10% (w/w) polyethylene glycol 400 and 3% (w/w) glycerol on the tinidazole release from a poly(DL-lactide) (PLA) injectable implant was evaluated. The results showed that the in vitro initial burst release rate was decreased in the presence of poly(ethyleneglycol) PEG 400 and glycerol. A formulation containing 30% (w/w) PLA (M(w) 7300) dissolved in 62% (w/w) N-methyl-2-pyrrolidone, 5% (w/w) PEG 400, and 3%(w/w) glycerol with 5% (w/w) tinidazole was shown to be optimum. Twelve adult beagle dogs were used in the periodontitis model. The treatment group I, II, and positive control group was administrated with gel containing 5%(w/w) tinidazole, 2.5%(w/w) tinidazole, and periocline, respectively. Dog studies revealed that periocline and the developed formulation could significantly decrease symptoms of periodontitis, and they were better than gel containing 2.5% (w/w) tinidazole. The developed formulation could sustain the release of tinidazole for local delivery over 7 days. These findings suggested that the developed formulation was a viable alternative to conventional drug to cure periodontitis.

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Tinidazole inhibitory and cidal activity against anaerobic periodontal pathogens

Cited by 13 publications

References 21 publications

New Insights into Prevotella Diversity and Medical Microbiology

New Insights into Prevotella Diversity and Medical Microbiology

In Vitro Killing Activity of Crevicular Concentrations of Tinidazole Plus Common Oral Antibiotics Against High‐Density Mixed Inocula of Periodontal Pathogens in Strict Anaerobic Conditions

Formulation and evaluation of in situ forming PLA implant containing tinidazole for the treatment of periodontitis

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