Tinidazole and Doxycycline as Antimicrobials in Elective Colorectal Surgery: A Randomized Multicentre Trial

Ofstad, E; Brabrand, G; Helsingen, N; Uggerud, R; Jørgensen, Jens Lohfert; Lien, Eric L.; Sandvik, F; Foss, Joseph F.; Danielsen, Steinar; Garberg, O.; Trovåg, Arne

doi:10.1080/15027708.1980.12288765

Antimicrobial prophylaxis for colorectal surgery

Nelson¹,

Glenny²,

Song³

2009

Cochrane Database of Systematic Reviews

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BACKGROUND: Research shows that administration of prophylactic antibiotics before colorectal surgery prevents postoperative surgical wound infection (SWI). The best antibiotic choice, timing of administration and route of administration remain undetermined. OBJECTIVES: To establish the effectiveness of antimicrobial prophylaxis for the prevention of SWI in patients undergoing colorectal surgery: specifically to determine, 1 Whether it reduces risk of SWI. 2 The target spectrum/a of bacteria (aerobic and/or anaerobic). 3 The best timing and duration of antibiotic administration. 4 The most effective route of antibiotic administration (intravenous, oral or both). 5 Whether any antibiotic is clearly more effective than the currently recommended gold standard.

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Antimicrobial prophylaxis for colorectal surgery

Nelson

¹

,

Glenny

²

,

Song

³

2014

Cochrane Database of Systematic Reviews

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BACKGROUND: Research shows that administration of prophylactic antibiotics before colorectal surgery prevents postoperative surgical wound infection (SWI). The best antibiotic choice, timing of administration and route of administration remain undetermined. OBJECTIVES: To establish the effectiveness of antimicrobial prophylaxis for the prevention of SWI in patients undergoing colorectal surgery: specifically to determine, 1 Whether it reduces risk of SWI. 2 The target spectrum/a of bacteria (aerobic and/or anaerobic). 3 The best timing and duration of antibiotic administration. 4 The most effective route of antibiotic administration (intravenous, oral or both). 5 Whether any antibiotic is clearly more effective than the currently recommended gold standard.

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Infectious problems in elective non-colorectal abdominal surgery

Danielsen¹

1988

Current Medical Research and Opinion

5

0

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The incidence of post-operative infectious complications after high-risk biliary and gastroduodenal and all cases of small bowel surgery was investigated in 965 patients included in a prospective multi-centre study. Selected types of operation where antibiotic prophylaxis was considered beneficial were defined and patients in these categories were to receive a standardizedprophylactic regimen of 400 mg doxycycline plus 1600 mg tinidazole intravenously I-hour pre-operatively or at induction of anaesthesia. Of the 965patients, 408 did not receive prophylaxis, 547 received the standard regimen and 10 were given a different prophylaxis. The overall compliance rate with the protocol was 89%. Analysis of the results of clinical evaluation of the patients 3, 7 and 15 days after surgery showed that only 21 (2.1%) of the 965 patients had developed surgical infectious complications. Two (0.2%) patients died of septic complications. No serious side-effects of the prophylactic regimen were recorded.

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Tinidazole and Doxycycline as Antimicrobials in Elective Colorectal Surgery: A Randomized Multicentre Trial

Cited by 5 publications

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Antimicrobial prophylaxis for colorectal surgery

Antimicrobial prophylaxis for colorectal surgery

Antimicrobial prophylaxis for colorectal surgery

Infectious problems in elective non-colorectal abdominal surgery

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