Tinea unguium in Lahore, Pakistan

Abstract

During a period of 1 year, out of 202 clinically suspected cases of tinea unguium, 53 (26%) were confirmed by mycological cultures for dermatophytes. Trichophyton rubrum was the most common fungus isolated in 46 (87%) patients, followed by T. violaceum in four (7%), T. interdigitale in two (4%) and Epidermophyton floccosum in one (2%). The disease was more common in adult males and fingernails were found to be affected more often than toenails. The distal and lateral variety was seen in 41 (77%) patients, total secondary dystrophic type in 11 (21%) and proximal subungual type in one (2%). Clinical diagnosis alone is not reliable and mycological confirmation is mandatory for this potentially curable disease.

Characteristics of superficial mycoses in Malta

“…The patients with tinea unguium in this study were young. This result is consistent with some reports, 5,10,11,13–15 but differs from others, which show an increased prevalence of this infection in patients who are more than 50 years of age 17–19 . Children were the least affected by tinea unguium, as reported in other studies 15,18 .…”

“…This study confirms previous reports that dermatophytosis is most prevalent in the younger age group, which is probably due to the heightened physical activities common in this group 4,7 . The results obtained are in agreement with other studies, which show that, worldwide, T. rubrum heads the list of isolated dermatophytes as the most frequent isolate reported 5,7,10–16 …”

“…Children were the least affected by tinea unguium, as reported in other studies 15,18 . There were more females ( n = 17) than males ( n = 14) with tinea unguium (Although this was not found to be statistically significant at P < 0.05), which differs from other reports 8,15 . From the results of this study, toenails were more commonly infected with dermatophytes than fingernails, which is similar to some reports, 18,19 but differs from others 15 .…”

Preparation, antimicrobial activity, and toxicity of 2‐amino‐4‐arylthiazole derivatives

“…2-Amino-4-( p-chlorophenyl)-1,3-thiazole (1f ) was the most active compound that inhibited growth of T. mentagrophytes at 100 g/mL, followed by 2-amino-4-( pmethylphenyl)-1,3-thiazole (1b), which inhibited the fungus growth at 200 g/mL. This is an important fact because T. mentagrophytes, a keratinophilic filamentous fungus, is the causal agent inducing dermatophytosis infections of hair, skin, and nails [18][19][20][21][22]. In addition, Trichophyton species may cause invasive infections in immune-compromised hosts [23].…”

Antimicrobial activities ofGloriosa superbaLinn (Colchicaceae) extracts

“…The crude extract and its various fractions showed good to excellent activity against T. longifusus. T. longifusus belongs to the genus Trichophyton, which is the causative agent of dermatophytosis and infects the hair, skin, and nails [22,23]. Trichophyton species may cause invasive infections in immunocompromised hosts [24].…”