TiN, ZrN and DLC nanocoatings - a comparison of the effects on animals, in-vivo study

Hajduga, M.; Bobiński, Rafał

doi:10.1016/j.msec.2019.109949

Cited by 16 publications

(6 citation statements)

References 15 publications

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“…Therefore, Ti and Ti alloys with ceramic coatings not only provide a protective layer against wear and corrosion, but also exhibit good biocompatibility properties for implantable devices, such as knee and hip joints, heart valves, coronary stents, and intraocular lenses . In recent years, different kinds of coatings, such as TiN, ,, TiTaHfNbZr, Nb 2 O 5 , yttrium-doped hydroxyapatite coatings, , nanostructured rutile Ti dioxide (NanoR-TiO 2 ), have been developed to improve the tribological properties and biocompatibility of Ti/Ti-alloys. Furthermore, it has been reported that the coating of Ti with a biologically active amorphous film, such as amorphous carbon nitride (CN x ) or diamond-like carbon (DLC)-doped Ti (TiC:H), Si-doped DLC coatings, Ag- and N-doped DLC coatings, and (Si:N)-DLC coatings appear to be a promising alternative.…”

Section: Introductionmentioning

confidence: 99%

SiC_xN_yO_z Coatings Enhance Endothelialization and Bactericidal activity and Reduce Blood Cell Activation

Bhaskar

Sulyaeva

Gatapova

et al. 2020

ACS Biomater. Sci. Eng.

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For biomedical applications, a number of ceramic coatings have been investigated, but the interactions with the components of living system remain unexplored for oxycarbonitride coatings. While addressing this aspect, the present study aims to provide an understanding of the biocompatibility of novel SiC x N y O z coatings that could validate the hypothesis that such coatings may not only enhance the cell–material interaction by re-endothelialization but also can help to reduce bacterial adhesion and activation of blood cells. This work reports the physicochemical properties, hemocompatibility, endothelialization, and antibacterial properties of novel amorphous SiC x N y O z coatings deposited on commercial pure titanium (Ti) by radiofrequency (RF) magnetron sputtering at varied nitrogen (N2) flow rates. A comparison is made with diamond-like carbon (DLC) coatings, which are clinically used. The surface roughness, surface wettability, nanoscale hardness, and surface energy of SiC x N y O z coatings were found to be dependent on the nitrogen (N2) flow rate. Importantly, the as-deposited SiC x N y O z coatings exhibited much better nanoscale hardness and scratch resistance than DLC coatings. Furthermore, Raman spectroscopy analysis of the SiC x N y O z coating deposited on Ti showed a change in the graphitic/disordered carbon content. Cytocompatibility and hemocompatibility properties of the as-deposited SiC x N y O z coating were evaluated using the Mus musculus lymphoid endothelial cell line (SVEC4-10) and rabbit blood in vitro. WST-1 assay analysis showed that these coatings, when compared to DLC, exhibited a better proliferation of endothelial cells, which can potentially result in improved surface endothelialization. Furthermore, qualitative and quantitative analyses of immunofluorescence images revealed a dense cellular layer of SVEC4-10 on SiC x N y O z coatings, deposited at 15 and 30 sccm nitrogen flow rates. As far as compatibility with rabbit blood is concerned, the hemolysis of the SiC x N y O z coatings was less than 4%, with slightly lower values for coatings deposited without N2 flow. The SiC x N y O z coatings support less platelet adhesion and aggregation, with no signature of morphological deformation, as compared to the uncoated titanium substrate or DLC coatings. Furthermore, SiC x N y O z coatings were also found to be effectively extending the blood coagulation time for a period of 60 min. The antimicrobial study of as-deposited SiC x N y O z coatings on E. coli and S. aureus bacteria revealed the effective inhibition of bacterial proliferation after 24 h of culture. An attempt has been made to explain the cyto- and hemocompatibility properties with antimicrobial efficacy of coatings in terms of the variation in the coating composition and surface energy. Taken together, we conclude that SiC1.3N0.76O0.87 coating having a roughness of 17 nm and a surface free energy of 54.0 ± 0.7 mN/m can exhibit the best combination of hardness, elastic modulus, scratch resistance, cytocompatibility...

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Section: Introductionmentioning

confidence: 99%

SiC_xN_yO_z Coatings Enhance Endothelialization and Bactericidal activity and Reduce Blood Cell Activation

Bhaskar

Sulyaeva

Gatapova

et al. 2020

ACS Biomater. Sci. Eng.

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“…For that reason, applied as coatings on Ti substrates by a CVD technique, the DLC film substantially improved the nano-hardness and tribological performance, decreasing the coefficient of friction by one order of magnitude [237,238]. The in vivo behavior of PVD-deposited DLC coatings on Ti substrates indicated no inflammatory reactions, confirming its good biocompatibility [239]. However, some disadvantages such as high internal stress, low toughness and high sensitivity to ambient conditions can be observed for a single layer of DLC coating that can explain the high revision rates of singlelayered DLC-coated orthopedic joints [240].…”

Section: Carbon-based Coatingsmentioning

confidence: 88%

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Nikolova

Apostolova

2022

Materials

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To fix the bone in orthopedics, it is almost always necessary to use implants. Metals provide the needed physical and mechanical properties for load-bearing applications. Although widely used as biomedical materials for the replacement of hard tissue, metallic implants still confront challenges, among which the foremost is their low biocompatibility. Some of them also suffer from excessive wear, low corrosion resistance, infections and shielding stress. To address these issues, various coatings have been applied to enhance their in vitro and in vivo performance. When merged with the beneficial properties of various bio-ceramic or polymer coatings remarkable bioactive, osteogenic, antibacterial, or biodegradable composite implants can be created. In this review, bioactive and high-performance coatings for metallic bone implants are systematically reviewed and their biocompatibility is discussed. Updates in coating materials and formulations for metallic implants, as well as their production routes, have been provided. The ways of improving the bioactive coating performance by incorporating bioactive moieties such as growth factors, osteogenic factors, immunomodulatory factors, antibiotics, or other drugs that are locally released in a controlled manner have also been addressed.

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“…Moreover, research on coatings in animal organisms has also been performed. Hajduga et al [80] compared the influence of titanium implants with TiN, ZrN, and DLC a-C:H coatings on animal organisms. Their research did not show any significant differences between the examined materials.…”

Section: Biomedical Application For Dlc Filmmentioning

confidence: 99%

Preparation and Characterization of Diamond-like Carbon Coatings for Biomedical Applications—A Review

2023

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Diamond-like carbon (DLC) films are generally used in biomedical applications, mainly because of their tribological and chemical properties that prevent the release of substrate ions, extend the life cycle of the material, and promote cell growth. The unique properties of the coating depend on the ratio of the sp3/sp2 phases, where the sp2 phase provides coatings with a low coefficient of friction and good electrical conductivity, while the share of the sp3 phase determines the chemical inertness, high hardness, and resistance to tribological wear. DLC coatings are characterized by high hardness, low coefficient of friction, high corrosion resistance, and biocompatibility. These properties make them attractive as potential wear-resistant coatings in many compelling applications, including optical, mechanical, microelectronic, and biomedical applications. Another great advantage of DLC coatings is that they can be deposited at low temperatures on a variety of substrates and can thus be used to coat heat-sensitive materials, such as polymers. Coating deposition techniques are constantly being improved; techniques based on vacuum environment reactions are mainly used, such as physical vapor deposition (PVD) and chemical vapor deposition (CVD). This review summarizes the current knowledge and research regarding diamond-like carbon coatings.

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TiN, ZrN and DLC nanocoatings - a comparison of the effects on animals, in-vivo study

Cited by 16 publications

References 15 publications

SiC_xN_yO_z Coatings Enhance Endothelialization and Bactericidal activity and Reduce Blood Cell Activation

SiC_xN_yO_z Coatings Enhance Endothelialization and Bactericidal activity and Reduce Blood Cell Activation

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Preparation and Characterization of Diamond-like Carbon Coatings for Biomedical Applications—A Review

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TiN, ZrN and DLC nanocoatings - a comparison of the effects on animals, in-vivo study

Cited by 16 publications

References 15 publications

SiCxNyOz Coatings Enhance Endothelialization and Bactericidal activity and Reduce Blood Cell Activation

SiCxNyOz Coatings Enhance Endothelialization and Bactericidal activity and Reduce Blood Cell Activation

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Preparation and Characterization of Diamond-like Carbon Coatings for Biomedical Applications—A Review

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Product

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SiC_xN_yO_z Coatings Enhance Endothelialization and Bactericidal activity and Reduce Blood Cell Activation

SiC_xN_yO_z Coatings Enhance Endothelialization and Bactericidal activity and Reduce Blood Cell Activation