TIMP1 and MMP9 are predictors of mortality in septic patients in the emergency department and intensive care unit unlike MMP9/TIMP1 ratio: Multivariate model

Niño, María Eugenia; Serrano, Sergio E.; Niño, Daniela Camila; McCosham, Diana Margarita; Cárdenas, María Eugenia; Villareal, Vivian Poleth; López, Marcos; Pazin‐Filho, Antônio; Jaimes, Fabián; Cunha, Fernando; Schulz, Richard; Torres-Dueñas, Diego

doi:10.1371/journal.pone.0171191

Cited by 25 publications

(41 citation statements)

References 34 publications

(64 reference statements)

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“…Among the enzymes secreted by leukocytes, MMPs and their inhibitors are induced and involved in this systemic inflammatory cascade [8][9][10]; particularly MMP-9 has been shown to cleave inactive TNF-alpha into its active form [11]. The MMPs and their inhibitors have been associated with mortality in organ injury [12][13][14] and sepsis [15], where serum levels of TIMP-1 and TIMP-1/MMP-9 ratios have been associated with disease severity and mortality [16][17][18].…”

Section: Mmps and Timps In Critical Illness And Cardiovascular Diseasementioning

confidence: 99%

Plasma MMP-9 and TIMP-1 levels on ICU admission are associated with 30-day survival

Jordakieva

Budge-Wolfram

Budinsky

et al. 2020

Wien Klin Wochenschr

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Background Matrix metalloproteinases (MMPs) are involved in systemic inflammatory responses and organ failure. The aim of this study was to evaluate early circulating plasma levels of MMP-2, MMP-9 and their inhibitors TIMP-1 and TIMP-2 and their prognostic significance in critically ill patients on admission to the intensive care unit (ICU). Methods In a single center prospective study 120 consecutive patients (72.5% male, mean age 66.8 ± 13.3 years, mean simplified acute physiology score [SAPS II] score 52.9 ± 21.9) were enrolled on transfer to the

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Section: Mmps and Timps In Critical Illness And Cardiovascular Diseasementioning

confidence: 99%

Plasma MMP-9 and TIMP-1 levels on ICU admission are associated with 30-day survival

Jordakieva

Budge-Wolfram

Budinsky

et al. 2020

Wien Klin Wochenschr

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“…International Sepsis De nitions 21 , which was used by seven articles. 17,[22][23][24][25][26][27] One article used the sampling of blood cultures as inclusion criterion. 28 One article included patients with symptoms of systemic infection in which PCT or blood cultures were taken within 24 hours of admission.…”

Section: Resultsmentioning

confidence: 99%

“…22,31 Only a minority of the articles used a prede ned cutoff of the studied biomarkers and scoring system. 17,25,27,29 There were no concerns of possible bias in ow and timing of the biomarkers and scoring systems that were investigated. Blood sampling was performed during ED visit in all studies.…”

Section: Quadas-2 Quality Assessmentmentioning

confidence: 99%

Predicting mortality in patients with sepsis in the emergency department by using combinations of biomarkers and clinical scoring systems: a systematic review.

Tong‐Minh¹,

Welten²,

Endeman³

et al. 2020

Preprint

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Introduction Sepsis can be detected in an early stage in the emergency department (ED) by biomarkers and clinical scoring systems. A combination of multiple biomarkers or biomarker with clinical scoring system might result in a higher predictive value on mortality. The goal of this systematic review is to evaluate the available literature on combinations of biomarkers and clinical scoring systems on 1-month mortality in patients with sepsis in the ED.Methods We performed a systematic search using MEDLINE, PubMed, EMBASE and Google Scholar. Articles were included if they evaluated at least one biomarker combined with another biomarker or clinical scoring system and reported the diagnostic accuracy on 28 or 30 day mortality by area under the curve (AUC) in patients with sepsis. Results We found 18 articles in this systematic review. In these 18 articles, a total of 35 combinations of biomarkers and clinical scoring systems were studied of which 33 unique combinations. In total, seven different clinical scoring systems and 21 different biomarkers were investigated. The combination of procalcitonin (PCT), lactate, interleukin-6 (IL-6) and Simplified Acute Physiology Score-2 (SAPS-2) resulted in the highest AUC on 1-month mortality. Conclusion In this systematic review, the combination of PCT, IL-6, lactate and the SAPS-2 score had the highest AUC on 1-month mortality in patients with sepsis in the ED. The studies we found in this review were too heterogeneous to conclude that a certain combination it should be used in the ED to predict 1-month mortality in patients with sepsis.

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“…CFD and VWF are important biomarkers of acute mortality for severe sepsis (Avriel et al, 2014;Gragnano et al, 2017). TIMP1 could be used as prognostic marker for the onset of sepsis (Nino et al, 2017). Sepsis is attenuated by inhibition of ABCC4 in rats (Xia et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Integration Analysis of m6A-SNPs and eQTLs Associated With Sepsis Reveals Platelet Degranulation and Staphylococcus aureus Infection are Mediated by m6A mRNA Methylation

et al. 2020

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Sepsis is a major threat with high mortality rate for critically ill patients. Response to pathogen infection by the host immune system is a key biological process involved in the onset and development of sepsis. Heterogeneous host genome variation, especially single nucleotide polymorphisms (SNPs), has long been suggested to contribute to differences in disease progression. However, the function of SNPs located in noncoding regions remains to be elucidated. Recently, m 6 A mRNA modification levels were revealed to differ at SNPs. As m 6 A is a crucial regulator of gene expression, these SNPs might control genes by changing the m 6 A level on mRNA. To investigate the potential role of m 6 A SNPs in sepsis, we integrated m 6 A-SNP and expression quantitative trait loci (eQTLs) data. Analysis revealed 15,720 m 6 A-cis-eQTLs and 381 m 6 A-trans-eQTLs associated with sepsis. We identified 1321 genes as locations of m 6 A-cis-eQTLs. These were enriched in platelet degranulation and Staphylococcus aureus infection pathways, which are vital for the pathophysiological process of sepsis. We conclude that m 6 A modification of mRNA plays a very important role in sepsis, with m 6 A-cis-eQTLs potentially having the most effect on individual variation in sepsis progression.

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TIMP1 and MMP9 are predictors of mortality in septic patients in the emergency department and intensive care unit unlike MMP9/TIMP1 ratio: Multivariate model

Cited by 25 publications

References 34 publications

Plasma MMP-9 and TIMP-1 levels on ICU admission are associated with 30-day survival

Plasma MMP-9 and TIMP-1 levels on ICU admission are associated with 30-day survival

Predicting mortality in patients with sepsis in the emergency department by using combinations of biomarkers and clinical scoring systems: a systematic review.

Integration Analysis of m6A-SNPs and eQTLs Associated With Sepsis Reveals Platelet Degranulation and Staphylococcus aureus Infection are Mediated by m6A mRNA Methylation

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