TIMP-1 gene polymorphism: are genetics able to predict outcome of septic patients?

Behnes, Michael; Bertsch, Thomas; Hoffmann, Ursula

doi:10.1186/cc12799

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…Patients with T allele show higher serum levels of TIMP‐1 19 . The association between this TIMP‐1 polymorphism and other diseases was reported in previous studies, for example, systemic sclerosis, 20 sepsis, 21 chronic obstructive pulmonary disease, 22 and primary open‐angle glaucoma 23 . However, there is scarcity in the studies investigating the association between this polymorphism and dermatological disorders.…”

Section: Discussionmentioning

confidence: 88%

MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) genes polymorphism in an Egyptian sample of Acne vulgaris patients

Mohammed¹,

Sabry

Ameen

et al. 2021

J of Cosmetic Dermatology

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Background Different Matrix metalloproteinases (MMPs) family members may be implicated in acne vulgaris development. However, there are no published data about the role of MMP‐1 and TIMP‐1 gene polymorphisms in acne vulgaris development. Aims To evaluate the association between MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) gene polymorphisms and the risk of developing acne vulgaris among a sample of Egyptian acne patients. Patients/Methods This case‐control study included 100 acne vulgaris patients and 120 apparently healthy control subjects. Acne severity was assessed according to Global Acne Grading System (GAGS). MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) gene polymorphisms were investigated using RFLP‐PCR technique. Results The MMP‐1 (519 A/G) AG and GG genotypes and G allele increase the risk of acne vulgaris~2–3 folds. In female patients, TIMP‐1 (372 C/T) TT genotype and T allele showed significantly higher frequency in cases compared with the control group (p = 0.004, 0.001 respectively) with a higher risk to develop acne. On the other hand, in male patients, there was insignificant difference between the frequency of alleles in patients and control subjects. TIMP‐1 (372C/T) TT genotype has been shown to be significantly detected in the studied female patients associated with the positive family history of the disease, and it increases the risk of back affection, severe acne grade development, and the liability to postacne scar formation. Conclusion MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) gene polymorphisms may be related to acne vulgaris development.

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Section: Discussionmentioning

confidence: 88%

MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) genes polymorphism in an Egyptian sample of Acne vulgaris patients

Mohammed¹,

Sabry

Ameen

et al. 2021

J of Cosmetic Dermatology

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“…Gene polymorphism refers to the variation of gene sequences in the same population. Gene polymorphisms determine the susceptibility or tolerance of the body to stress stimuli and the diversity of clinical manifestations and drug therapeutic effects, thus further affecting an infected host's gene expression and prognosis (Behnes et al, 2013;Thompson et al, 2014). With the deepening understanding of genomics, genetic differences are considered to be the internal basis for the occurrence and development of many diseases.…”

Section: Gene Polymorphismsmentioning

confidence: 99%

Immune Intervention in Sepsis

Chen

Wei

2021

Front. Pharmacol.

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Sepsis is a host immune disorder induced by infection. It can lead to multiple organ dysfunction syndrome (MODS), which has high morbidity and mortality. There has been great progress in the clinical diagnosis and treatment of sepsis, such as improvements in pathogen detection technology, innovations regarding anti-infection drugs, and the development of organ function support. Abnormal immune responses triggered by pathogens, ranging from excessive inflammation to immunosuppression, are recognized to be an important cause of the high mortality rate. However, no drugs have been approved specifically for treating sepsis. Here, we review the recent research progress on immune responses in sepsis to provide a theoretical basis for the treatment of sepsis. Constructing and optimizing a dynamic immune system treatment regimen based on anti-infection treatment, fluid replacement, organ function support, and timely use of immunomodulatory interventions may improve the prognosis of sepsis patients.

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“…In the previous issue of Critical Care , Behnes and colleagues [ 1 ] provide an interesting commentary on our study showing that septic patients with the T-allele in 372 T/C (rs4898) genetic polymorphism of the tissue inhibitor of metalloproteinase-1 (TIMP-1) had higher mortality and higher TIMP-1 serum levels than those without it [ 2 ].…”

mentioning

confidence: 99%

The 372 T/C genetic polymorphism of TIMP-1 as a biomarker of mortality in patients with sepsis

Lorente

Martı́n

2013

Crit Care

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TIMP-1 gene polymorphism: are genetics able to predict outcome of septic patients?

Cited by 6 publications

References 15 publications

MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) genes polymorphism in an Egyptian sample of Acne vulgaris patients

MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) genes polymorphism in an Egyptian sample of Acne vulgaris patients

Immune Intervention in Sepsis

The 372 T/C genetic polymorphism of TIMP-1 as a biomarker of mortality in patients with sepsis

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