Timolol transport from microemulsions trapped in HEMA gels

Contact Lenses for Drug Delivery

“…Contact lenses containing oil-surfactant microemulsions laden with timolol have also been fabricated. 25 Each contact lens was able to load about 1 mg of lidocaine. The hydrogels then demonstrated a sigmoid-shaped release curve over 60 days in deionized water, but the conditions of the release experiments were not physiological.…”

Drug release characteristics of modified PHEMA hydrogel containing thermo-responsive pluronic copolymer

“…To enhance the potential of PHEMA hydrogels for use in drug delivery systems, its chemical bonding with drugs or copolymerization with monomers containing ionic or hydrophobic groups has been widely studied. 18,19 In our previous study, 20 we have synthesized and characterized PHEMA hydrogels containing the Pluronic, PEO-PPO-PEO triblock copolymer, which is well known as a thermoresponsive biocompatible polymer. The resulting PHEMAco-Pluronic composite hydrogels possessed a microporous structure with improved mechanical strength, and exhibited a thermally responsive swelling-deswelling behavior caused by the temperature-induced molecular rearrangement of Pluronic component within the hydrogel matrix.…”

Cation transfer across a hydrogel/organic phase: Effect of cation size, hydrophobicity and acid–base properties

“…Hydrogels are robust, three-dimensional, cross-linked structures that swell in water, and these materials have many potential applications [27][28][29][30][31][32][33][34][35][36][37]. These applications are closely related to the intrinsic properties of the polymeric networks [29,[31][32][33][34][35][36][37], and two main characteristics of hydrogels should be emphasized: their chemical structures and the morphology of their networks.…”

“…These applications are closely related to the intrinsic properties of the polymeric networks [29,[31][32][33][34][35][36][37], and two main characteristics of hydrogels should be emphasized: their chemical structures and the morphology of their networks. The former affects the hydrophilic/hydrophobic ratio of the gel, and consequently, its water retention and absorption capacity.…”