Timolol Lowers Intraocular Pressure but Does Not Inhibit the Development of Experimental Myopia in Chick

Schmid, Katrina L.; Abbott, Meredith; Humphries, Michelle; Pyne, Kylie; Wildsoet, Christine F.

doi:10.1006/exer.2000.0834

Cited by 34 publications

(35 citation statements)

References 32 publications

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“…CCTS, CCBS, ODTS, TDTS and MCTS) compared with Trusopt and a number of other drugs that are used in glaucoma treatment or generally in ophthalmology, i.e. Benoxinate (local anaesthesia) [13], Tropamid (anticholinergy, midriatic) [14], Gentagut (antibacterial) [15]. All compounds were tested against the purified dog carbonic anhydrase enzyme.…”

Section: Resultsmentioning

confidence: 99%

Purification of carbonic anhydrase from dog erythrocytes and investigation ofin vitroinhibition by various compounds

Bayram

Arslan

Uğraş

et al. 2007

Journal of Enzyme Inhibition and Medicinal Chemistry

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The enzyme carbonic anhydrase (E.C. 4.2.1.1) has a stimulatory effect on glaucoma, an eye disease that has a risk to dogs, which are models for the human eye disease, that is similar to that in humans.In this study, some sulfonamide derivatives, 2-(3-cyclohexene-1-carbamido)-1,3,4-thiadiazole-5-sulfonamide (CCTS), 4-(3-cyclohexene-1-carbamido) methyl-benzenesulfonamide (CCBS), 2-(9-octadecenoylamido)-1,3,4-thiadiazole-5-sulfonamide (ODTS), 2-(4,7,10-trioxa-tetradecanoylamido)-1,3,4-thiadiazole-5-sulfonamide (TDTS), and 2-(8-methoxycoumarine-3-carbamido)-1,3,4-thiadiazole-5-sulfonamide (MCTS), as well as some anionic compounds (perchlorate and chloride) and existing medicines (dorzolamide-HCl, gentamicine sulphate, tropicamide, and procaine-HCl) were assayed for their inhibition of dog carbonic anhydrase (dCA), which was purified from erythrocytes on an affinity gel of L-tyrosinesulfonamide-Sepharose 4B. ODTS showed the highest potency amongst the synthetic compounds with IC 50 value 1.18 £ 10 25 M. Amongst the medicines tested, only dorzolamide showed inhibition with IC 50 value 5.05 £ 10 24 M. Procaine and tropicamide actually showed an activatory effect, whereas gentamicine sulfate had no significant effect. The inhibitory effects of anionic compounds such as perchlorate and chloride were also investigated; whereas perchlorate showed inhibition, chloride did not.

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Section: Resultsmentioning

confidence: 99%

Purification of carbonic anhydrase from dog erythrocytes and investigation ofin vitroinhibition by various compounds

Bayram

Arslan

Uğraş

et al. 2007

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…IOP was observed to initially decrease in eyes wearing either negative or positive lenses, although the faster-growing eyes showed a later relative increase in IOP. 12 However, in a related study, 13 topical timolol, an IOP-lowering drug, failed to inhibit lens-induced myopic growth in young chicks.…”

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confidence: 97%

The Role of the Iris in Chick Accommodation

Ostrin

Liu

Choh

et al. 2011

Invest. Ophthalmol. Vis. Sci.

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Refraction and eye growth were minimally affected by ID in chickens, implying that emmetropization was unaffected and supporting the use of ID as a tool in emmetropization and myopia studies. The greatly attenuated accommodative responses in vitro for iridectomized eyes suggest a role of biomechanical factors in the chick. IOP was unaffected by the surgery, implying that the iris musculature is not essential for maintaining aqueous outflow pathways.

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“…Pharmacological reduction of intraocular pressure had no effect on experimentally-induced myopia or hyperopia (Schmid et al, 2000), suggesting that intraocular pressure does not play a direct role in controlling the growth of the chick eye postnatally. Taken together, the results of these previous studies and the results of the present study indicate that in chicks, embryonic eye growth is dependent on intraocular pressure, whereas visually guided postnatal ocular growth is dependent on proteoglycan synthesis in the sclera.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Scleral Proteoglycan Synthesis Blocks Deprivation-induced Axial Elongation in Chicks

Rada¹,

Johnson²,

Achen³

et al. 2002

Experimental Eye Research

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Timolol Lowers Intraocular Pressure but Does Not Inhibit the Development of Experimental Myopia in Chick

Cited by 34 publications

References 32 publications

Purification of carbonic anhydrase from dog erythrocytes and investigation ofin vitroinhibition by various compounds

Purification of carbonic anhydrase from dog erythrocytes and investigation ofin vitroinhibition by various compounds

The Role of the Iris in Chick Accommodation

Inhibition of Scleral Proteoglycan Synthesis Blocks Deprivation-induced Axial Elongation in Chicks

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