Timing recalibration in childhood Tourette syndrome associated with persistent pimozide treatment

Vicario, Carmelo M.; Gulisano, Mariangela; Martino, Davide; Rizzo, Renata

doi:10.1111/jnp.12064

Cited by 19 publications

(16 citation statements)

References 59 publications

(76 reference statements)

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“…The research on timing skills in TS is still in its infancy. Studies of Vicario et al ( , 2016 confirmed a tendency of this clinical population to overestimate supra-second durations, in the absence of pharmacological treatment, in a time reproduction task (see also Martino D. et al, 2019;Vicario et al, 2020, for further contributions in the field of time processing). This response pattern correlated with tic severity .…”

Section: Tourette's Syndromementioning

confidence: 59%

“…With regard to time representation, making estimations about a target that was previously experienced requires a more direct involvement of memory processes, although it takes place also in the case of a target that is going to be experienced. In the second case, it is required to make predictions about the duration of the target to be timed, such as in the case of sports actions, where the accuracy in predicting the duration of a target (i.e., a moving ball) is crucial for successful sportive performance (Vicario et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Time Processing, Interoception, and Insula Activation: A Mini-Review on Clinical Disorders

et al. 2020

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Time processing is a multifaceted skill crucial for managing different aspects of life. In the current work, we explored the relationship between interoception and time processing by examining research on clinical models. We investigated whether time processing deficits are associated with dysfunction of the interoceptive system and/or insular cortex activity, which is crucial in decoding internal body signaling. Furthermore, we explored whether insular activation predicts the subjective experience of time (i.e., the subjective duration of a target stimulus to be timed). Overall, our work suggests that alteration of the interoceptive system could be a common psychophysiological hallmark of mental disorders affected by time processing deficits.

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Section: Tourette's Syndromementioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Time Processing, Interoception, and Insula Activation: A Mini-Review on Clinical Disorders

et al. 2020

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“…This result was explained by suggesting the existence of an effective compensatory modulation phenomenon, in correspondence of the prefrontal cortex, leading to better tic inhibition and increased precision in explicit processing of supra-second time intervals. Dopaminergic modulation seems also relevant to temporal discrimination in TS patients, as dopamine receptor blockers like pimozide may improve patients' variability on this task (Vicario et al, 2016). …”

Section: Evidence On Motor Timing Abnormalities In Movement Disordersmentioning

confidence: 99%

Time Processing and Motor Control in Movement Disorders

Avanzino

Pelosin

Vicario

et al. 2016

Front. Hum. Neurosci.

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The subjective representation of “time” is critical for cognitive tasks but also for several motor activities. The neural network supporting motor timing comprises: lateral cerebellum, basal ganglia, sensorimotor and prefrontal cortical areas. Basal ganglia and associated cortical areas act as a hypothetical “internal clock” that beats the rhythm when the movement is internally generated. When timing information is processed to make predictions on the outcome of a subjective or externally perceived motor act, cerebellar processing and outflow pathways appear to be primarily involved. Clinical and experimental evidence on time processing and motor control points to a dysfunction of the neural networks involving basal ganglia and cerebellum in movement disorders. In some cases, temporal processing deficits could directly contribute to core motor features of the movement disorder, as in the case of bradykinesia in Parkinson's disease. For other movement disorders, the relationship between abnormal time processing and motor performance is less obvious and requires further investigation, as in the reduced accuracy in predicting the temporal outcome of a motor act in dystonia. We aim to review the literature on time processing and motor control in Parkinson's disease, dystonia, Huntington's disease, and Tourette syndrome, integrating the available findings with current pathophysiological models; we will highlight the areas in which future explorations are warranted, as well as the aspects of time processing in motor control that present translational aspects in future rehabilitation strategies. The subjective representation of “time” is critical for cognitive tasks but also for motor activities. Recently, greater attention has been devoted to improve our understanding of how temporal information becomes integrated within the mechanisms of motor control. Experimental evidence recognizes time processing in motor control as a complex neural function supported by diffuse cerebral networks including cortical areas, cerebellum, and other subcortical structures (Ivry and Spencer, 2004; Coull and Nobre, 2008). Timing is an essential component of motor control primarily within two types of motor tasks: (i) when producing sequential rhythmic movements or sustained movements of a definite duration (explicit timing); (ii) when the temporal information is used implicitly, such as when coordinating our movements to those of moving objects or individuals within the external environment (implicit timing). In this review, we will provide a brief description of the neural network supporting motor timing focusing only on instrumental information to explain the link between timing and motor control in movement disorders. Then we will review available data on motor timing in Parkinson's disease, dystonia, Huntington's disease, and Tourette syndrome, and discuss how this body of evidence integrates with the available information on the pathophysiology of these movement disorders. Finally, we will discuss the translational aspects of the exp...

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“…See refs 31 , 32 , for reviews). The evidence of dopaminergic alteration in PTSD (e.g., refs 33 , 34 ) adds a neurochemical rationale to the hypothesis of timing deficits in this clinical population, according to the research linking dopamine with the internal clock functions 17 , 35 – 39 .…”

Section: Introductionmentioning

confidence: 99%

Slower Time estimation in Post-Traumatic Stress Disorder

Vicario

Felmingham

2018

Sci Rep

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Cognitive deficits in Posttraumatic Stress Disorder (PTSD) and dissociative symptoms suggest there may be an underlying and persistent problem with temporal processing in PTSD, but this question has not been systematically examined. We investigated the ability of a group of PTSD participants in estimating the duration of supra-second visual stimuli relative to healthy controls. The data of 59 participants with PTSD and 62 healthy controls, collected from the BRID database, have been examined. Overall, our results indicate that PTSD patients overestimate the duration of the displayed stimuli. Moreover, we found that PTSD are more variable in the time estimation compared to the control group. Finally, we found evidence that working memory and attention impairments were associated with time overestimation in PTSD. The finding of time overestimation in PTSD accords with previous reports of time overestimation during stressful experiences associated with fear and arousal, but extends findings to suggest it remains in chronic PTSD populations processing non-emotional stimuli. The evidence of time overestimation in PTSD suggests the potential relevance of this factor as a cognitive marker in assessing the neuropsychological profile of this clinical population.

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Timing recalibration in childhood Tourette syndrome associated with persistent pimozide treatment

Cited by 19 publications

References 59 publications

Time Processing, Interoception, and Insula Activation: A Mini-Review on Clinical Disorders

Time Processing, Interoception, and Insula Activation: A Mini-Review on Clinical Disorders

Time Processing and Motor Control in Movement Disorders

Slower Time estimation in Post-Traumatic Stress Disorder

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