Timing of preoperative antibiotic prophylaxis in 54,552 patients and the risk of surgical site infection

Jonge, Stijn De; Gans, Sarah L.; Atema, Jasper J.; Solomkin, Joseph S.; Dellinger, Patchen; Boermeester, Marja A.

doi:10.1097/md.0000000000006903

Cited by 144 publications

(122 citation statements)

References 39 publications

(137 reference statements)

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“…(24,25) The use of the checklist can support adherence, and this study demonstrated that the impact factor for SSI reduction was the adherence to the antibiotic administration schedule evidenced by checking antibiotic prophylaxis in the second period of the checklist administration, before the skin incision. During the period prior to the implementation of the checklist, there was no institutional control of proper surgical prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

Comparação das taxas de infecção cirúrgica após implantação do checklist de segurança

et al. 2018

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Objective: To compare surgical site infection rates in clean surgery before and after implementation of the checklist proposed by the World Health Organization. Methods: Observational, descriptive, retrospective correlational study performed in a general hospital. Sample consisting of 15,319 records of clean surgeries monitored by the hospital Infection Prevention and Control Service, in the trauma, orthopedics, cardiovascular, plastic, general, and urology specialties. Before implementing the checklist, 5,481 records were evaluated; 9,838 records were reviewed after. Analysis was performed with SPSS 22.0 software and application of the Pearson's chi-square test, considering p <0.05. Results:The overall infection rate in clean surgery was 4.17% in the pre-implementation period of the checklist and 1.10% post-implementation (p<0.05), with statistically signifi cant reductions in spine, aneurysm and bypass, abdominoplasty, mammoplasty, herniorrhaphy and prostatectomy surgeries. Conclusion: A signifi cant reduction was identifi ed in the rate of surgical site infection in clean surgeries when comparing the pre-and postimplementation periods of the checklist proposed by the World Health Organization. ResumoObjetivo: Comparar taxas de infecção de sítio cirúrgico em cirurgia limpa antes e após implantação do checklist proposto pela Organização Mundial de Saúde. Métodos: Estudo observacional, descritivo, retrospectivo do tipo correlacional, realizado em um hospital geral. Amostra constituída por 15.319 registros de cirurgias limpas das especialidades traumato-ortopedia, cardiovascular, plástica, geral e urologia monitoradas pelo Serviço de Controle de Infecção Hospitalar. Antes da implantação do checklist foram avaliados 5.481 registros e após 9.838. Análise realizada com Software SPSS 22.0 e aplicação do teste qui-quadrado de Pearson, considerando-se signifi cativo p<0,05. Resultados: A taxa geral de infecção em cirurgia limpa foi 4.17% no período pré-implantação do checklist e 1.10% pós (p<0.05), com redução estatisticamente signifi cativa nas cirurgias de coluna, aneurisma e by-pass, abdominoplastia, mamoplastia, herniorrafi a e prostatectomia. Conclusão: Observou-se redução signifi cativa da taxa de infecção de sítio cirúrgico nas cirurgias limpas quando comparados os períodos pré e pós-implantação do checklist proposto pela Organização Mundial de Saúde. ResumenObjetivo: Comparar tasas de infección de sitio quirúrgico en cirugía limpia antes y después de implantación del checklist propuesto por Organización Mundial de la Salud. Métodos: Estudio observacional, descriptivo, retrospectivo, tipo correlacional, realizado en hospital general. Muestra de 15.319 registros de cirugías limpias de traumatología-ortopedia, cardiovascular, plástica, general y urología, monitoreadas por Servicio de Control de Infección Hospitalaria. Antes de implantarse el checklist fueron evaluados 5.481 registros, y 9.838 después. Análisis realizado aplicando Software SPSS 22.0 y test de Chi-cuadrado, considerándose signifi catividad d...

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Section: Discussionmentioning

confidence: 99%

Comparação das taxas de infecção cirúrgica após implantação do checklist de segurança

et al. 2018

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“…As mentioned, guidelines have indicated that prophylactic antibiotics should be given at least one hour before surgery, although others have indicated longer, and stopped 24 h after the initial incision [4,22,23]. In case of contaminated and dirty wounds, presumptive treatment should be undertaken [21].…”

Section: Case Definitionmentioning

confidence: 99%

“…Surgical site infections (SSIs) increase morbidity, mortality and costs, and can be particularly problematic in low and middle income countries (LMICs) [1][2][3][4][5]. They are a common cause of hospital acquired infections, and can be common after certain surgical procedures [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Firstly, antibiotics should be given 30 min to 60 min before the initial incision to allow for the drug tissue concentration to rise above the minimum inhibitory concentration [13,22,23], although others have suggested within the first 120 min [4]. Additional doses of prophylactic antibiotics may be required for procedures longer than 3 h [20].…”

Section: Introductionmentioning

confidence: 99%

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Determinants of the Effectiveness of Antimicrobial Prophylaxis among Neurotrauma Patients at a Referral Hospital in Kenya: Findings and Implications

Ao¹,

Jmw²,

Ao³

et al. 2017

J Infect Dis Preve Med

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Background: Surgical site infections can occur adding to morbidity, mortality and costs, and can be particularly problematic in low and middle income countries. This includes infections in neurosurgical patients following surgery despite antimicrobial prophylaxis. The study aimed at measuring the incidence of surgical site infections (SSIs) and identifying factors that influence the effectiveness of antimicrobial prophylaxis in a leading hospital in Kenya.

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“…Although surgeons follow a certain protocol for antibiotic therapy after open heart surgeries, due to the potentially hazardous post cardiac surgery infections, the duration and type of prophylactic antibiotic remains a controversial challenge (3,4). Surgical site infection has always been an expensive and uncomfortable problem, and in particular, cardiovascular surgery may have devastating consequences and can occur as an infectious problem in 3-10% of cases (5).…”

Section: Introductionmentioning

confidence: 99%

Impact of Different Prophylactic Antibiotic Regimen on Clinical Outcome of Coronary Artery Bypass Graft Surgery

Shirnia

Hadavand

Mirzaei

et al. 2017

Multidiscip CardioAnnal

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Background: Prevention of surgical site infection is the first concern in cardiac surgery. Deep sternal infection causes death in patients and increases the length of hospitalization and the cost of treatment. Several therapeutic protocols have long been used by cardiac surgeons for antimicrobial prophylaxis. The aim of this study is to evaluate the clinical outcomes of prescribing different antibiotic prophylaxis in patients undergoing coronary artery bypass graft surgery.

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Timing of preoperative antibiotic prophylaxis in 54,552 patients and the risk of surgical site infection

Abstract: Supplemental Digital Content is available in the text

Cited by 144 publications

References 39 publications

Comparação das taxas de infecção cirúrgica após implantação do checklist de segurança

Comparação das taxas de infecção cirúrgica após implantação do checklist de segurança

Determinants of the Effectiveness of Antimicrobial Prophylaxis among Neurotrauma Patients at a Referral Hospital in Kenya: Findings and Implications

Impact of Different Prophylactic Antibiotic Regimen on Clinical Outcome of Coronary Artery Bypass Graft Surgery

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