Timing of postoperative radiation therapy and survival in resected salivary gland cancers: Long-term results from a single institution

Romine, Perrin E.; Voutsinas, Jenna; Wu, Vicky; Tratt, Micah; Liao, Jay J.; Parvathaneni, Upendra; Barber, Brittany; Dillon, Jasjit K.; Timoshchuk, Mari-Alina; Futran, Neal; Houlton, Jeffrey; Laramore, George E.; Martins, Renato; Eaton, Keith D.; Rodriguez, Cristina P.

doi:10.1016/j.oraloncology.2021.105626

Cited by 1 publication

(1 citation statement)

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“…A retrospective single-institution study of 180 patients with salivary gland cancer was also published in 2021 and demonstrated that there was no statistical difference in either OS or locoregional recurrencefree survival when stratifying S-PORT into quartiles (Q1, 8-47; Q2, 48-61; Q3, 62-72; Q4, 73-121 days). 15) Moreover, it demonstrated no significant difference in survival outcomes between patients with S-PORT <6 and ≥6 weeks in a multivariate model. However, a study having different threshold of S-PORT other than 6 weeks found that S-PORT >60 days in patients with oral cavity and oropharyngeal cancer resulted in impaired OS.…”

Section: Discussionmentioning

confidence: 89%

Association of Time Interval From Surgery to Postoperative Radiation Therapy With Survival for Patients With Head and Neck Cancer

Choi¹,

Cho²,

Oh³

et al. 2023

Korean J Otorhinolaryngol-Head Neck Surg

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Background and Objectives Oncologic effect of initiating postoperative radiotherapy (PORT) in adherance with the National Comprehensive Cancer Network Guidelines remains uncertain. This study aimed to reassess the impact of time of initiating PORT over 6 weeks on survival.Subjects and Method Patients were dichotomized into groups according to the time of initiation, those that initiated PORT ≤6 weeks and those that initiated PORT >6 weeks postoperatively. The Kaplan-Meier, univariate, and multivariate analyses were then conducted. Outcome measures were overall survival (OS) and progression-free survival (PFS).Results OS rates at 5 years for the group that initiated PORT ≤6 weeks and those that initiated PORT >6 weeks were 86.3% and 72.9%, respectively (log-rank <i>p</i>=0.26). PFS rates at 5 years for the group of PORT ≤6 and for the group of PORT >6 weeks were 65.6% and 65.9%, respectively (log-rank <i>p</i>=0.95).Conclusion In this study, there was no statistical difference in OS and PFS rate between groups that began initiation of PORT ≤6 and those that began >6 weeks. In the future, retrospective studies with more patients will be needed to further confirm our observation from this study.

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Section: Discussionmentioning

confidence: 89%