Timing of last COVID-19 vaccine dose and SARS-CoV-2 breakthrough infections in fully (boosted) vaccinated healthcare personnel

Maltezou, Helena C.; Gamaletsou, Maria N.; Giannouchos, Theodoros V.; Koukou, Dimitra‐Maria; Karapanou, Αmalia; Sourri, Flora; Syrimi, Natalia; Lemonakis, Nikolaos; Peskelidou, Emmanuela; Papanastasiou, Konstantina; Souliotis, Kyriakos; Lourida, Athanasia; Panagopoulos, Periklis; Hatzigeorgiou, Dimitrios; Sipsas, Nikolaos V.

doi:10.1016/j.jhin.2022.11.016

Cited by 5 publications

(3 citation statements)

References 24 publications

(30 reference statements)

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“…Booster vaccination was defined as a complete primary vaccination series followed by a further dose at least six months later [ 14 ]. The inferential analysis was conducted on HW that had received, from September 2021 to June 2022, the booster dose of BNT162b2 (Pfizer-BioNTech), mRNA-1273 (Moderna), ChAdOx1 nCoV-19 (Oxford–AstraZeneca), and Ad26.COV2.S (Johnson).…”

Section: Methodsmentioning

confidence: 99%

Incidence and Determinants of Symptomatic and Asymptomatic SARS-CoV-2 Breakthrough Infections After Booster Dose in a Large European Multicentric Cohort of Health Workers-ORCHESTRA Project

Porru,

Monaco,

Spiteri

et al. 2023

J Epidemiol Glob Health

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Background SARS-CoV-2 breakthrough infections (BI) after vaccine booster dose are a relevant public health issue. Methods Multicentric longitudinal cohort study within the ORCHESTRA project, involving 63,516 health workers (HW) from 14 European settings. The study investigated the cumulative incidence of SARS-CoV-2 BI after booster dose and its correlation with age, sex, job title, previous infection, and time since third dose. Results 13,093 (20.6%) BI were observed. The cumulative incidence of BI was higher in women and in HW aged < 50 years, but nearly halved after 60 years. Nurses experienced the highest BI incidence, and administrative staff experienced the lowest. The BI incidence was higher in immunosuppressed HW (28.6%) vs others (24.9%). When controlling for gender, age, job title and infection before booster, heterologous vaccination reduced BI incidence with respect to the BNT162b2 mRNA vaccine [Odds Ratio (OR) 0.69, 95% CI 0.63–0.76]. Previous infection protected against asymptomatic infection [Relative Risk Ratio (RRR) of recent infection vs no infection 0.53, 95% CI 0.23–1.20] and even more against symptomatic infections [RRR 0.11, 95% CI 0.05–0.25]. Symptomatic infections increased from 70.5% in HW receiving the booster dose since < 64 days to 86.2% when time elapsed was > 130 days. Conclusions The risk of BI after booster is significantly reduced by previous infection, heterologous vaccination, and older ages. Immunosuppression is relevant for increased BI incidence. Time elapsed from booster affects BI severity, confirming the public health usefulness of booster. Further research should focus on BI trend after 4th dose and its relationship with time variables across the epidemics.

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Section: Methodsmentioning

confidence: 99%

Incidence and Determinants of Symptomatic and Asymptomatic SARS-CoV-2 Breakthrough Infections After Booster Dose in a Large European Multicentric Cohort of Health Workers-ORCHESTRA Project

Porru,

Monaco,

Spiteri

et al. 2023

J Epidemiol Glob Health

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“…Therefore, breakthrough cases have been expected and reported worldwide [ 2 , 3 ]. In Maltezou et al’s study of 1493 fully vaccinated healthcare workers, only four (0.3%) were hospitalized with COVID-19, none required mechanical ventilation, and the mortality rate was zero [ 4 ]. Most breakthrough infections were observed three months after the last dose of vaccine, which can be explained by decreased vaccine immunity.…”

Section: Introductionmentioning

confidence: 99%

Adolescents With Breakthrough COVID-19 Infections Requiring Hospitalization: A Multicenter Retrospective Study

Şahbudak Bal,

Yildirim Arslan,

Guner Ozenen

et al. 2024

Cureus

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BackgroundVaccines have the most important role in the battle against the COVID-19 pandemic. With the widespread use of vaccines, COVID-19 has remarkably declined. Adolescents were vaccinated after approvals for this age group, which was later than adults, and a nationwide vaccination program was implemented in August 2021 in Turkey for adolescents ≥12 years of age. Therefore, we aimed to determine the effects of the COVID-19 nationwide adolescent vaccination program on adolescent hospitalizations due to COVID-19 and multisystem inflammatory syndrome in children (MIS-C) by comparing two periods, including the vaccination period (VP) and the pre-VP (PVP). The second aim of this study is to compare the clinical features and disease severity of vaccine-breakthrough COVID-19 hospitalizations with unvaccinated individuals in the VP.

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“… 31 , 32 In addition, patients who are fully vaccinated (FV) against COVID-19 reduced length of hospital stay, risk of ICU admission, and risk of death compared to those who are not vaccinate, and these vaccines protect against SARS-CoV-2 infection. 33 , 34 However, the risk of a breakthrough case of severe COVID-19 following vaccination remains, especially among people at higher risk of severe disease. 35 , 36 …”

Section: Introductionmentioning

confidence: 99%

Measuring efficiency of the global fight against the COVID-19 pandemic

2023

DIGITAL HEALTH

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Objectives The ongoing COVID-19 pandemic has led to an unprecedented loss of life and a severe economic downturn across the globe. Countries have adopted various social distancing and vaccination policies to reduce the spread of the disease and lessen the impact on healthcare systems. The world should work together to confront the disaster and challenge of COVID-19. Methods This study uses stochastic frontier analysis to measure the efficiency and influencing factors of the global response to COVID-19 epidemics and to provide follow-up strategies and reference guidelines. Results The results of this study show that (1) the average efficiency of the global response to COVID-19 is not good, with significant space for improvement of up to 60%; (2) adequate medical supplies and equipment can reduce mortality; (3) the initial implementation of social distancing policies and wearing masks can effectively reduce the infection rate; and (4) as infection rates and vaccination rates increase so that most people have basic immunity to COVID-19, the epidemic will gradually be reduced. Conclusions As the world becomes more aware of the COVID-19 disease, humans will gradually return to normal social interaction and lifestyles. The results of this study are expected to provide a reference for the future direction of the global fight against epidemics and the improvement of public health policies.

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Timing of last COVID-19 vaccine dose and SARS-CoV-2 breakthrough infections in fully (boosted) vaccinated healthcare personnel

Cited by 5 publications

References 24 publications

Incidence and Determinants of Symptomatic and Asymptomatic SARS-CoV-2 Breakthrough Infections After Booster Dose in a Large European Multicentric Cohort of Health Workers-ORCHESTRA Project

Incidence and Determinants of Symptomatic and Asymptomatic SARS-CoV-2 Breakthrough Infections After Booster Dose in a Large European Multicentric Cohort of Health Workers-ORCHESTRA Project

Adolescents With Breakthrough COVID-19 Infections Requiring Hospitalization: A Multicenter Retrospective Study

Measuring efficiency of the global fight against the COVID-19 pandemic

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