Timing of introduction of complementary foods, breastfeeding, and child cardiometabolic risk: a prospective multiethnic Asian cohort study

Ong, Yi Ying; Pang, Wei Wei; Michael, Navin; Aris, Izzuddin M.; Sadananthan, Suresh Anand; Tint, Mya‐Thway; Choo, Jonathan Tze Liang; Ling, Lieng Hsi; Karnani, Neerja; Velan, S. Sendhil; Fortier, Marielle V.; Tan, Kok Hian; Gluckman, Peter D.; Yap, Fabian; Chong, Yap‐Seng; Godfrey, Keith M.; Chan, Shiao‐Yng; Eriksson, Johan G.; Chong, Mary Foong-Fong; Wlodek, Mary E.; Lee, Yung Seng

doi:10.1016/j.ajcnut.2022.10.021

Cited by 5 publications

(3 citation statements)

References 58 publications

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“…Despite this advice, successive infant feeding surveys have shown that the majority of UK children continue to be weaned before the age of 5 months [ 50 ]. Though we did not find the age of weaning as a significant contributor to the causal pathway between maternal and offspring adiposity in late childhood, there is still evidence showing very early age of weaning per se is associated with a higher risk of later adiposity [ 12 , 14 , 15 , 51 , 52 ]. Within that context, it has been suggested age of weaning might be a possible avenue for the prevention of the development of obesity [ 14 , 31 ].…”

Section: Discussioncontrasting

confidence: 65%

Maternal Pre-Pregnancy BMI, Offspring Adiposity in Late Childhood, and Age of Weaning: A Causal Mediation Analysis

et al. 2023

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Infant feeding practices have been hypothesized to influence offspring's body mass index (BMI) later in life, and women with overweight or obesity tend to wean their infants earlier than women with healthy BMI. We, therefore, aimed to investigate how much early age of weaning mediated the maternal-offspring adiposity relationship. The study included 4920 mother-child pairs from the Avon Longitudinal Study of Parents and Children birth cohort. G-computation was applied to estimate the natural direct (NDE) and indirect (NIE) effects, via the age of weaning (<3 months, 3 months, >3 months), of maternal pre-pregnancy overweight or obesity on offspring’s BMI and fat mass index. The NDE of maternal overweight or obesity on offspring BMI at 17 years old was 2.63 kg/m2 (95% CI: 2.27 to 2.99). The NIE via the age of weaning was 0.02 kg/m2 (95% CI: 0.00 to 0.04), corresponding to 0.8% of the total effect. Similar results were observed for the offspring’s fat mass index. The NDE and NIE were similar to the main analyses when we looked at the relationship stratified by breastfeeding status. Our study found a minimal influence of age of weaning on the pathway between maternal and offspring adiposity, indicating the age of weaning may not be a key mediator.

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Section: Discussioncontrasting

confidence: 65%

Maternal Pre-Pregnancy BMI, Offspring Adiposity in Late Childhood, and Age of Weaning: A Causal Mediation Analysis

et al. 2023

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“…13 Ong et al reported that a combination of early complementary feeding and short breastfeeding was associated with elevated child adiposity and cardiometabolic markers, including an increase in diastolic blood pressure and metabolic syndrome score. 14 Addressing the risk factors and promoting optimal practices can potentially contribute to improving infant growth outcomes and reducing the burden of malnutrition and associated health problems. Context-specific evidence is crucial for healthcare providers and policymakers to develop public health interventions aiming at improving both maternal and child health.…”

Section: Introductionmentioning

confidence: 99%

“…However, early introduction of solid foods (before 4 months of age) was associated with a higher risk of obesity in infancy 13 . Ong et al reported that a combination of early complementary feeding and short breastfeeding was associated with elevated child adiposity and cardiometabolic markers, including an increase in diastolic blood pressure and metabolic syndrome score 14 . Addressing the risk factors and promoting optimal practices can potentially contribute to improving infant growth outcomes and reducing the burden of malnutrition and associated health problems.…”

Section: Introductionmentioning

confidence: 99%

Influence of maternal characteristics and infant feeding patterns on infant growth from birth till 18 months: The MISC study

Radwan,

Naja,

Abbas

et al. 2024

Pediatric Obesity

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SummaryBackgroundThe growth and development of infants during the first 1000 days of life are crucial for their health.ObjectivesThis study aims to assess the impact of maternal characteristics and infant feeding patterns on infant growth from birth to 18 months.MethodsData were derived from the 2‐year perspective Mother Infant Study Cohort (MISC) study which included six visits from the third trimester of pregnancy until 18 months postpartum. A convenient sample of 256 pregnant women aged 19–40 years was recruited from Sharjah, Dubai and Ajman in the United Arab Emirates.ResultsAmongst mothers' characteristics, Arab nationality, pre‐pregnancy overweight/obesity, higher gestational weight gain and lower physical activity were found to increase the likelihood of infants being overweight at 6, 12 and 18 months. Exclusive breastfeeding was positively correlated with reduced odds of the infant being overweight at 18 months (aOR = 0.31, 95% CI: 0.12–0.81). Breastfeeding for up to 6 months and the introduction of solid foods after 6 months was associated with reduced odds of the infant being overweight at 12 months old (aOR = 4, 95% CI: 1.1–14.6; aOR = 2.97, 95% CI: 1.09–8.08, respectively).ConclusionThe findings spotlight the influence of maternal characteristics and infant feeding on infant growth. This asserts the need for evidence‐based programmes targeting mothers to promote optimal feeding practices and foster healthy child growth.

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Associations of infant feeding practices with abdominal and hepatic fat measures in childhood in the longitudinal Healthy Start Study

Cohen,

Harrall,

et al. 2024

The American Journal of Clinical Nutrition

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Timing of introduction of complementary foods, breastfeeding, and child cardiometabolic risk: a prospective multiethnic Asian cohort study

Cited by 5 publications

References 58 publications

Maternal Pre-Pregnancy BMI, Offspring Adiposity in Late Childhood, and Age of Weaning: A Causal Mediation Analysis

Maternal Pre-Pregnancy BMI, Offspring Adiposity in Late Childhood, and Age of Weaning: A Causal Mediation Analysis

Influence of maternal characteristics and infant feeding patterns on infant growth from birth till 18 months: The MISC study

Associations of infant feeding practices with abdominal and hepatic fat measures in childhood in the longitudinal Healthy Start Study

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