Timing of Intrapartum Ampicillin and Prevention of Vertical Transmission of Group B Streptococcus

Cueto, Marina de; Sanchez, M.; Sampedro, Antonio; Miranda, José; Herruzo, A; Rosa-Fraile, Manuel

doi:10.1016/s0029-7844(97)00587-5

Cited by 145 publications

(92 citation statements)

References 23 publications

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“…Duration of IAP of 4 hours of beta-lactam antibiotics has been shown to be highly effective in preventing vertical transmission of GBS and GBS EOD [18,124,126,131,132]. Even though not ideal, duration of IAP 2 hours can provide acceptable coverage [131,[133][134][135].…”

Section: Intrapartum Antibiotic Prophylaxismentioning

confidence: 99%

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Intrapartum GBS screening and antibiotic prophylaxis: a European consensus conference

Renzo

Melin²,

Berardi

et al. 2014

The Journal of Maternal-Fetal & Neonatal Medicine

153

135

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Group B streptococcus (GBS) remains worldwide a leading cause of severe neonatal disease. Since the end of the 1990s, various strategies for prevention of the early onset neonatal disease have been implemented and have evolved. When a universal antenatal GBS screening-based strategy is used to identify women who are given an intrapartum antimicrobial prophylaxis, a substantial reduction of incidence up to 80% has been reported in the USA as in other countries including European countries. However recommendations are still a matter of debate due to challenges and controversies on how best to identify candidates for prophylaxis and to drawbacks of intrapartum administration of antibiotics. In Europe, some countries recommend either antenatal GBS screening or risk-based strategies, or any combination, and others do not have national or any other kind of guidelines for prevention of GBS perinatal disease. Furthermore, accurate population-based data of incidence of GBS neonatal disease are not available in some countries and hamper good effectiveness evaluation of prevention strategies. To facilitate a consensus towards European guidelines for the management of pregnant women in labor and during pregnancy for the prevention of GBS perinatal disease, a conference was organized in 2013 with a group of experts in neonatology, gynecologyobstetrics and clinical microbiology coming from European representative countries. The group reviewed available data, identified areas where results were suboptimal, where revised procedures and new technologies could improve current practices for prevention of perinatal GBS disease. The key decision issued after the conference is to recommend intrapartum antimicrobial prophylaxis based on a universal intrapartum GBS screening strategy using a rapid real time testing.

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Section: Intrapartum Antibiotic Prophylaxismentioning

confidence: 99%

“…Even though not ideal, duration of IAP 2 hours can provide acceptable coverage [131,[133][134][135]. In cases of less than acceptable coverage (52 hours) the neonatologist should be informed.…”

Section: Intrapartum Antibiotic Prophylaxismentioning

confidence: 99%

Intrapartum GBS screening and antibiotic prophylaxis: a European consensus conference

Renzo

Melin²,

Berardi

et al. 2014

The Journal of Maternal-Fetal & Neonatal Medicine

153

135

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“…10,25,26 En este sentido, poder identificar grupos de embarazadas con mayor riesgo de infección aumenta la posibilidad de una mejor vigilancia perinatal y, por lo tanto, de prevenir, diagnosticar y tratar oportunamente este tipo de infección. 8,11 De acuerdo con lo anterior y con base en los resultados de este estudio, las acciones encaminadas a la prevención y control de la infección por SGB se deberían dirigir a la atención de la población de mayor riesgo de colonización con el fin de disminuir las probabilidades de infección y la transmisión perinatal de SGB.…”

Section: Discussionunclassified

“…21 Asimismo, la letalidad de la ENT suele abarcar a 55% de los casos, aunque se ha demostrado que un diagnóstico y tratamiento oportunos pueden disminuir dicha letalidad entre 13 y 37%. [25][26][27] Si bien el papel de los factores obstétricos ha sido ampliamente analizado en la mayoría de los trabajos sobre colonización materna por SGB, 2,5,8 el papel de los factores demográficos y socioeconómicos ha sido poco evaluado, no obstante la existencia de estudios que evidencian que factores como la edad 17 y el grupo étnico 6,15 pueden jugar un papel importante en la infección por SGB. Aun cuando en esos estudios no se explican los mecanismos por los cuales esos factores podrían incrementar la tasa de colonización por SGB sí sugieren que ésta podría estar vinculada a condiciones de pobreza y marginación, lo que, a su vez, se podría constituir en un elemento importante para identificar grupos de alto riesgo entre la población general.…”

Section: Objetivo Estimar La Prevalencia De Colonización Por Streptounclassified

Factores asociados a la colonización por Streptococcus del grupo B en mujeres embarazadas de Los Altos, Chiapas

Ocampo-Torres¹,

Sánchez-Pérez²,

Nazar-Beutelspacher³

et al. 2000

Salud pública Méx

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Moisés Ocampo-Torres, M.C., (1) Héctor Javier Sánchez-Pérez, Dr. en C., (1) Austreberta Nazar-Beutelspacher, Dr. en C., (1) Adriana Elena Castro-Ramírez, M. en C., (1) Bulmaro Cordero-Ocampo, M.C. (2) Este trabajo fue realizado gracias al apoyo financiero del Programa de Apoyo a Tesis de Maestría y al Departamento de Vinculación de El Colegio de la Frontera Sur, Chiapas, México.(1) El Colegio de la Frontera Sur, Unidad San Cristóbal de las Casas, Chiapas, México.(2) Jefatura de Enseñanza del Hospital General "I", Secretaría de Salud, San Cristóbal de las Casas, Chiapas, México. Vaginal and perianal samples were taken for GBS detection by bacteriological culture. Identification of groups and serotypes was performed using latex agglutination. The analysis of factors associated with colonization was done using chi-squared tests and log-linear modeling. Results. GBS colonization was found in 8.6% (95% CI 6.8 -10.5) of study subjects. Women with the greatest likelihood of colonization were those with ≥5 pregnancies, residents of counties with high levels of poverty, working outside the home, and living in homes in which the head of household worked in agriculture (26.8%, OR= 7.25, 95% CI 1.83 -28.67). Conclusions. In the study area, it is necessary that actions aiming to prevent and control infections by GBS be directed principally at those groups of women with the highest probability of colonization, in order to diminish the perinatal transmission of GBS.

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“…There is evidence that benzylpenicillin levels in cord blood exceed the minimum inhibitory concentration for GBS as early as 1 hour after maternal administration 51 but it is not known how this relates to neonatal colonisation or disease. There is also evidence that giving penicillin for 2 hours before delivery reduces neonatal colonisation 52,53 but evidence from 2013 54 suggests that 4 hours of penicillin is more effective than 2 hours at reducing the risk of EOGBS disease. Amoxicillin is an alternative but the Cochrane review 7 found no difference between amoxicillin and benzylpenicillin and thus, the narrower spectrum antibiotic is preferred.…”

mentioning

confidence: 99%

Prevention of Early‐onset Neonatal Group B Streptococcal Disease

2017

BJOG

126

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Timing of Intrapartum Ampicillin and Prevention of Vertical Transmission of Group B Streptococcus

Abstract: When the time between the start of ampicillin prophylaxis and delivery is at least 2 hours, vertical transmission of group B streptococcus is minimized.

Cited by 145 publications

References 23 publications

Intrapartum GBS screening and antibiotic prophylaxis: a European consensus conference

Intrapartum GBS screening and antibiotic prophylaxis: a European consensus conference

Factores asociados a la colonización por Streptococcus del grupo B en mujeres embarazadas de Los Altos, Chiapas

Prevention of Early‐onset Neonatal Group B Streptococcal Disease

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