Timing of First Respiratory Virus Detections in Infants: A Community-Based Birth Cohort Study

Sarna, Mohinder; Ware, Robert S.; Lambert, Stephen B.; Sloots, Theo P.; Nissen, Michael D.; Grimwood, Keith

doi:10.1093/infdis/jix599

Cited by 32 publications

(53 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found nearly five times more co-detections in our study than were reported from among the first viral detections of those enrolled in a community birth cohort from Brisbane. 3,27 EVs were observed to have an especially low proportion of co-detections in our 2001 sample. As reported in our earlier studies of populations from different years and Australian locations, we again observed that detection of an IFAV, EV, RV or RSV occurred with reduced likelihood of co-detection of any other virus in that patient's sample.…”

Section: Discussionmentioning

confidence: 60%

“…Infants from one to 12 months of age were most likely to be affected by RV or RSV in our convenience sample population; this agreed with findings from the Brisbane community cohort. 3 RV-positive children were second youngest after RSV-positive children while IFAV-positive children were generally older than those positive for any other virus. Interestingly, it is often children younger than 2 years who are affected by severe influenza.…”

Section: Discussionmentioning

confidence: 92%

“…These picornavirus species often occur in symptomatic young children from community and hospital populations where they create a sizable burden for management and are a frequent trigger of wheeze. [1][2][3] Picornavirus infections can more often be observed among children presenting to an emergency department than other respiratory virus infections. 4 Nearly three quarters of respiratory virus detection episodes during the first 28 days of life are due to RVs and over half are symptomatic.…”

Section: Introductionmentioning

confidence: 99%

“…4 Nearly three quarters of respiratory virus detection episodes during the first 28 days of life are due to RVs and over half are symptomatic. 3 Until recently, much of what is known of RV diversity, epidemiology and clinical impact was determined using human studies and cell culture methods in the 1950s to 1980s. In 2006, the molecular discovery of a genetic clade of RVs that could only be cultured in vitro using sophisticated air-liquid interface cultures was subsequently ratified as a third species, Rhinovirus C (RV-C).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Genotypic diversity, circulation patterns, and co-detections among rhinoviruses in Queensland, 2001

Arden

Greer

Wang

et al. 2018

Preprint

View full text Add to dashboard Cite

Rhinoviruses (RVs) occur more frequently than other viruses and more often in people displaying symptoms than in those without. RVs exacerbate chronic airway disease and confound the clinical diagnosis of influenza-like illness. We sought to estimate the spectrum of RV diversity, RV species seasonality and to breakdown RV involvement in respiratory virus co-detections by comprehensive molecular testing of a convenience collection of airway sample extracts from patients with suspected respiratory infections, collected during 2001.RVs were the most common virus detected. We were able to genotype ~90% of RV detections, identifying 70 distinct RVs, spanning all three species. RV-Bs were underrepresented. We found RV species co-circulated at times, although one species usually dominated. Each species displayed a bimodal distribution.Notably, RVs and influenza A viruses (IFAV) seldom co-occurred, supporting their roles as primary pathogens of the airway among acutely ill infants. Whether RV circulation has a moderating or controlling effect on the IFAV season or is controlled by it cannot be determined from these data.Despite the frequent perception that RVs commonly co-occur with another virus, our findings indicated this was not the case. Nearly 80% of RV detections occurred alone. Understanding more about population-level interference between viruses may allow us to harness aspects of it to generate a non-specific antiviral intervention that mimics a putative protective effect.For routine respiratory virus screening to best serve the patient, RV testing should be a principal component of any acute respiratory illness testing algorithm throughout the year.

show abstract

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genotypic diversity, circulation patterns, and co-detections among rhinoviruses in Queensland, 2001

Arden

Greer

Wang

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…For those of us interested in respiratory viruses, there is a lot to like about the study by Sarna et al that appears in this issue of The Journal of Infectious Diseases [1]. The study analyzes data from a birth cohort established as part of the Observational Research in Childhood Infectious Diseases (ORChID) Project, based in Brisbane, Australia [2].…”

mentioning

confidence: 99%

Respiratory Viruses in Babies: Important Insights From Down Under

Storch

2017

The Journal of Infectious Diseases

View full text Add to dashboard Cite

Bacterial colonization dynamics associated with respiratory syncytial virus during early childhood

Brealey

Young

Sloots

et al. 2020

Pediatric Pulmonology

Self Cite

View full text Add to dashboard Cite

Respiratory syncytial virus (RSV) is an important cause of early life acute respiratory infections. Potentially pathogenic respiratory bacteria, including Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae are frequently detected during RSV infections and associated with increased illness severity. However, the temporal dynamics of bacterial colonization associated with RSV infection remain unclear. We used weekly nasal swab data from a prospective longitudinal birth cohort in Brisbane, Australia, to investigate bacterial colonization patterns within children aged less than 2 years in the 4‐week period before and after an RSV infection. During 54 RSV infection episodes recorded in 47 children, both S. pneumoniae and M. catarrhalis were detected frequently (in 33 [61.1%] and 26 [48.1%] RSV infections, respectively). In most cases, S. pneumoniae and M. catarrhalis colonization preceded the viral infection, with the nasal load of each increasing during RSV infection. Generally, the dominant serotype of S. pneumoniae remained consistent in the 1 to 2 weeks immediately before and after RSV infection. Little evidence was found to indicate that prior colonization with either bacteria predisposed participants to developing RSV infection during the annual seasonal epidemic. Possible coacquisition events, where the bacteria species was first detected with RSV and not in the preceding 4 weeks, were observed in approximately 20% of RSV/S. pneumoniae and RSV/M. catarrhalis codetections. Taken together our results indicate that RSV generally triggered an outgrowth, rather than a new acquisition, of S. pneumoniae and M. catarrhalis from the resident microbial community.

show abstract

Timing of First Respiratory Virus Detections in Infants: A Community-Based Birth Cohort Study

Abstract: Infants do not always experience respiratory symptoms with their fVDE. Predominance of early HRV detections highlights the need for timing any intervention early in life. fVDEs from other respiratory viruses most commonly occur when maternal vaccines may no longer provide protection.

Cited by 32 publications

References 48 publications

Genotypic diversity, circulation patterns, and co-detections among rhinoviruses in Queensland, 2001

Genotypic diversity, circulation patterns, and co-detections among rhinoviruses in Queensland, 2001

Respiratory Viruses in Babies: Important Insights From Down Under

Bacterial colonization dynamics associated with respiratory syncytial virus during early childhood

Contact Info

Product

Resources

About