Timing of blood extraction in epidemiologic and proteomic studies: results and proposals from the PANKRAS II Study

Porta, Miquel; Pumarega, José; Ferrer-Armengou, Olga; López, Tomás; Alguacil, Joan; Malats, Núria; Fernández, Esteve

doi:10.1007/s10654-007-9192-4

Cited by 2 publications

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“…heparin, EDTA) (iv) if the participant is healthy, participant condition at the sample collection (fasting status, position, etc.) when appropriate; (v) if participants are not healthy individuals in stable physiological conditions, then report the relevant aspects of the health status and clinical conditions of the participants [24,25]; (vi) in all instances, consider reporting the time between sample collection and relevant clinical or physiological endpoints that might have affected the characteristics or concentrations of the biomarker [26]. In particular, report any relevant characteristic of the participants, which might influence the biomarker levels in any known or unknown way.…”

Section: Me-4 -Describe the Special Study Designs For Molecular Epidementioning

confidence: 99%

STrengthening the reporting of OBservational studies in Epidemiology—Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement

et al. 2011

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Section: Me-4 -Describe the Special Study Designs For Molecular Epidementioning

confidence: 99%

STrengthening the reporting of OBservational studies in Epidemiology—Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement

et al. 2011

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“…We also included 483 patients with pancreatic ductal adenocarcinoma (PC) of German [n=382; all recruited between 1996 and 2003 in the university hospitals in Berlin (n=89), Leipzig, Saxony (n=12) and Magdeburg, Saxony-Anhalt (n=281)], Swiss (n=35) and Spanish (n=66) origin in this study (Table 1). The diagnosis of pancreatic adenocarcinoma was either confirmed histologically or classified as exocrine pancreas cancer reviewed by a panel of experts [16].…”

Section: Study Subjectsmentioning

confidence: 99%

Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer

Treiber

Schulz²,

Landt³

et al. 2006

J Mol Med

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Keratin 8 (KRT8) is one of the major intermediate filament proteins expressed in single-layered epithelia of the gastrointestinal tract. Transgenic mice over-expressing human KRT8 display pancreatic mononuclear infiltration, interstitial fibrosis and dysplasia of acinar cells resulting in exocrine pancreatic insufficiency. These experimental data are in accordance with a recent report describing an association between KRT8 variations and chronic pancreatitis. This prompted us to investigate KRT8 polymorphisms in patients with pancreatic disorders. The KRT8 Y54H and G62C polymorphisms were assessed in a cohort of patients with acute and chronic pancreatitis of various aetiologies or pancreatic cancer originating from Austria (n=16), the Czech Republic (n=90), Germany (n=1698), Great Britain (n=36), India (n=60), Italy (n=143), the Netherlands (n=128), Romania (n=3), Spain (n=133), and Switzerland (n=129). We also studied 4,234 control subjects from these countries and 1,492 control subjects originating from Benin, Cameroon, Ethiopia, Ecuador, and Turkey. Polymorphisms were analysed by melting curve analysis with fluorescence resonance energy transfer probes. The frequency of G62C did not differ between patients with acute or chronic pancreatitis, pancreatic adenocarcinoma and control individuals. The frequency of G62C varied in European populations from 0.4 to 3.8%, showing a northwest to southeast decline. The Y54H alteration was not detected in any of the 2,436 patients. Only 3/4,580 (0.07%) European, Turkish and Indian control subjects were heterozygous for Y54H in contrast to 34/951 (3.6%) control subjects of African descent. Our data suggest that the KRT8 alterations, Y54H and G62C, do not predispose patients to the development of pancreatitis or pancreatic cancer.

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Timing of blood extraction in epidemiologic and proteomic studies: results and proposals from the PANKRAS II Study

Cited by 2 publications

References 0 publications

STrengthening the reporting of OBservational studies in Epidemiology—Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement

STrengthening the reporting of OBservational studies in Epidemiology—Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement

Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer

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