Timing metabolism in cartilage and bone: links between circadian clocks and tissue homeostasis

Gonçalves, Cátia F.; Meng, Qing‐Jun

doi:10.1530/joe-19-0256

Cited by 16 publications

(8 citation statements)

References 182 publications

(225 reference statements)

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“…Oscillating core circadian transcription factors and their immediate downstream targets and mediators have been demonstrated in murine calvarial bone over a 24 h cycle [ 169 ]. Positive (Bmal1) and negative (Cry1/2, Per1/2) regulators were rhythmically expressed in the expected antiphase relationship [ 154 ]. Circadian oscillation was clearly illustrated in ex vivo cultures of long and flat bones using Per2- luc reporter mice [ 170 ], and a 24 h interval rhythmic expression of Per2 was observed in the fracture healing sites in an ex vivo culture study of long bone [ 171 ].…”

Section: Environmental Cues Regulating Osteogenesismentioning

confidence: 99%

“…While Per1 - and Per2 -deficient mice are normal, Per1 -/- ;Per2 -/- and Per1 -/- ;Per2 m/m double mutant mice showed high bone mass phenotypes, indicating that PER1 and PER2 may compensate each other [ 166 ]. The antagonistic outcomes when disrupting positive (Clock/Bmal1) and negative (Per1/2) regulators is expected, in relation to low and high bone mass, respectively [ 154 ].…”

Section: Environmental Cues Regulating Osteogenesismentioning

confidence: 99%

“…Osteoblasts are influenced by the circadian clock in tissue homeostasis and at healing About 3-16% of genes expressed in the peripheral tissues are rhythmic [154]. This molecular clock is controlled by core clock transcription factors that exert opposing positive (CLOCK and BMAL1) and negative (period, PER1/2/3; and cryptochrome, CRY1/2) outcomes, forming a feedback loop that follows the light/dark cycle [155,156].…”

Section: Circadian Clock Regulates Osteogenesismentioning

confidence: 99%

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Regulation and Role of Transcription Factors in Osteogenesis

Chan

Tan

et al. 2021

IJMS

125

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Bone is a dynamic tissue constantly responding to environmental changes such as nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone remodeling, a controlled and balanced process between bone-resorbing osteoclasts and bone-forming osteoblasts. Osteoblasts secrete matrix, with some being buried within the newly formed bone, and differentiate to osteocytes. During embryogenesis, bones are formed through intramembraneous or endochondral ossification. The former involves a direct differentiation of mesenchymal progenitor to osteoblasts, and the latter is through a cartilage template that is subsequently converted to bone. Advances in lineage tracing, cell sorting, and single-cell transcriptome studies have enabled new discoveries of gene regulation, and new populations of skeletal stem cells in multiple niches, including the cartilage growth plate, chondro-osseous junction, bone, and bone marrow, in embryonic development and postnatal life. Osteoblast differentiation is regulated by a master transcription factor RUNX2 and other factors such as OSX/SP7 and ATF4. Developmental and environmental cues affect the transcriptional activities of osteoblasts from lineage commitment to differentiation at multiple levels, fine-tuned with the involvement of co-factors, microRNAs, epigenetics, systemic factors, circadian rhythm, and the microenvironments. In this review, we will discuss these topics in relation to transcriptional controls in osteogenesis.

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Section: Environmental Cues Regulating Osteogenesismentioning

confidence: 99%

Section: Environmental Cues Regulating Osteogenesismentioning

confidence: 99%

Section: Circadian Clock Regulates Osteogenesismentioning

confidence: 99%

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Regulation and Role of Transcription Factors in Osteogenesis

Chan

Tan

et al. 2021

IJMS

125

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“…The existence of circadian rhythms has been reported in bone tissue, and bone disorders are associated with the occurrence of osteoporosis. [63][64][65][66][67] Furthermore, F I G U R E 9 RANKL expression was regulated by Rev-Erbα but not by direct binding to RANKL. Rev-Erbα Sequence logo (A), frequency matrix (B), TFFM first order summary logos (C) and TFFM peak logo (D).…”

Section: Discussionmentioning

confidence: 95%

Melatonin inhibits osteoclastogenesis via RANKL/OPG suppression mediated by Rev‐Erbα in osteoblasts

Tian

Ming

2022

J Cellular Molecular Medi

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Concurrent with improvements in living standards and changes in living habits, the global incidence of diabetes has been increasing yearly. 1 Several diabetes-related complications, including diabetic osteoporosis, pose severe threats to the well-being of people with diabetes. 2,3 Although the pathogenesis of diabetic osteoporosis is unclear, recent studies have suggested it may be related to the influence of a high-glucose environment on metabolism, subsequently affecting bone formation, and may be realized through gene polymorphism changes. 4 Diabetic osteoporosis may also be caused by excessive reactive oxygen species (ROS) production 5-7 and advanced glycation end products. 5,[8][9][10] In addition, hyperglycaemia can promote the nonenzymatic glycosylation of diverse bone

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“…OP is commonly described as a "silent disease" because it lacks obvious signs, and has now become an important public health issue, with estimates indicating that nearly 200 million individuals are impacted worldwide [4]. Multiple risk factors are thought to contribute to the increased likelihood of OP, including sex, age, race, hormone levels, dietary factors, and lifestyle choices [5][6][7].…”

Section: Introduction Overviewmentioning

confidence: 99%

Global Public Interests and Dynamic Trends in Osteoporosis From 2004 to 2019: Infodemiology Study

Wang¹,

Xu²,

Cao³

et al. 2021

J Med Internet Res

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Background With the prolonging of human life expectancy and subsequent population aging, osteoporosis (OP) has become an important public health issue. Objective This study aimed to understand the global public search interests and dynamic trends in “osteoporosis” using the data derived from Google Trends. Methods An online search was performed using the term “osteoporosis” in Google Trends from January 1, 2004, to December 31, 2019, under the category “Health.” Cosinor analysis was used to test the seasonality of relative search volume (RSV) for “osteoporosis.” An analysis was conducted to investigate the public search topic rising in RSV for “osteoporosis.” Results There was a descending trend of global RSV for “osteoporosis” from January 2004 to December 2014, and a slowly increasing trend from January 2015 to December 2019. Cosinor analysis showed significant seasonal variations in global RSV for “osteoporosis” (P=.01), with a peak in March and a trough in September. In addition, similar decreasing trends of RSV for “osteoporosis” were found in Australia, New Zealand, Ireland, and Canada from January 2004 to December 2019. Cosinor test revealed significant seasonal variations in RSV for “osteoporosis” in Australia, New Zealand, Canada, Ireland, UK, and USA (all P<.001). Furthermore, public search rising topics related to “osteoporosis” included denosumab, fracture risk assessment tool, bone density, osteopenia, osteoarthritis, and risk factor. Conclusions Our study provided evidence about the public search interest and dynamic trends in OP using web-based data, which would be helpful for public health and policy making.

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Timing metabolism in cartilage and bone: links between circadian clocks and tissue homeostasis

Cited by 16 publications

References 182 publications

Regulation and Role of Transcription Factors in Osteogenesis

Regulation and Role of Transcription Factors in Osteogenesis

Melatonin inhibits osteoclastogenesis via RANKL/OPG suppression mediated by Rev‐Erbα in osteoblasts

Global Public Interests and Dynamic Trends in Osteoporosis From 2004 to 2019: Infodemiology Study

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