Timely mental health care for the 2022 novel monkeypox outbreak is urgently needed

Ahmed, Sirwan Khalid; M-Amin, Halkawt Ismail; Abdulqadir, Salar Omar; Hussein, Safin Hassan; Ahmed, Zheno Kareem; Essa, Rawand Abdulrahman; Khdir, Awat Alla; Abdulla, Araz Qadir; Omar, Rukhsar Muhammad

doi:10.1016/j.amsu.2022.104579

Cited by 20 publications

(24 citation statements)

References 7 publications

(9 reference statements)

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“…This is consistent with the results of complications and sequelae of monkeypox. Additionally, my results show that monkeypox infection is associated with Schizophrenia and Mental depression, which supports the conclusion that monkeypox infection can lead to psychiatric disorders, such as anxiety, depression, and depression responses[29, 30]. Prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase 2 (COX-2), is the rate-limiting enzyme in the production of prostaglandins (PGs), plays an important role in various tumors and is also an important marker of iron death signaling pathway[31, 32].…”

Section: Discussionsupporting

confidence: 77%

Section: Cirrhosis，myocardial Ischemia，inflammation，reperfusion Injur...supporting

confidence: 81%

“…Mental depression, which supports the conclusion that monkeypox infection can lead to psychiatric disorders, such as anxiety, depression, and depression responses [29,30].…”

Section: Cirrhosis，myocardial Ischemia，inflammation，reperfusion Injur...supporting

confidence: 75%

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A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions

Tang

Mao

Meng³

et al. 2022

Preprint

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Monkeypox has been spreading worldwide since May 2022, when the World Health Organization (WHO) declared the outbreak of a "Public health emergency of international concern". The spread of monkeypox has posed a serious threat to the health of people all over the world but few studies have been carried out on it, and the molecular mechanism of monkeypox after infection remains unclear. We therefore implemented a transcriptome analysis to identify signaling pathways and biomarkers in monkeypox-infected cells to help understand monkeypox-host cell interactions. In this study, the dataset GSE36854 and GSE11234 were obtained from GEO. Among them, 84 significantly different genes were identified in the dataset GSE36854, followed by KEGG, GO analysis protein-protein interaction (PPI) construction and Hub gene extraction. We also analyzed the expression regulation patterns of hub genes and screened the drugs targeting the hub genes. The results showed that monkeypox-infected cells significantly activated the cellular immune response, and induced inflammatory response. IER3, IFIT2, IL11, ZC3H12A, EREG, IER2, NFKBIE, FST, IFIT1 and AREG were the top 10 hub genes, in which anti-viral gene IFIT1 and IFIT2 were significantly suppressed. AP-26113 and itraconazole promoting the expression of IFIT1 and IFIT2 may be used as new candidates for the treatment of monkeypox viral infection. Our results provide a new entry point for understanding the mode of interaction between monkeypox virus and its host. Keywords: Monkeypox, transcriptome sequencing, protein-protein interaction, IFIT2

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Section: Discussionsupporting

confidence: 77%

Section: Cirrhosis，myocardial Ischemia，inflammation，reperfusion Injur...supporting

confidence: 81%

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A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions

Tang

Mao

Meng³

et al. 2022

Preprint

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“…Disasters and traumatic life events typically have an impact on a person's psychological makeup. For instance, the development of epidemics or endemics may lead to an increase in psychological conditions such sadness, anxiety, post-traumatic stress disorder, and emotions of sorrow [9]. Due of the added burden on the sick person's mentality, it may even result in suicide in some circumstances [9].…”

Section: Suicidementioning

confidence: 99%

Monkeypox and Psychotic Manifestations: Possible But Little Recognized Clinical Manifestations

Sookaromdee¹,

Wiwanitkit

2022

wjcm

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The pox virus is an important pathogen that can cause disease in humans. Monkeypox is a unique type of pox infection. The WHO has acknowledged the seriousness of a massive monkeypox outbreak in 2022. The disease usually presents as an acute febrile illness with skin lesions. The patient usually has many painful vesicular lesions, and this is a common cause of complaint for patients visiting the physician. The patient usually has a history of contact with an infected case and gets the disease. However, sometimes fever or skin damage cannot be detected. Without the special appearance, doctors may miss the problem and make the wrong diagnosis. Basically, clinical diagnosis is the simplest procedure and must be used by practitioners. Laboratory methods can help confirm the diagnosis. The gold standard for diagnosis is molecular-based diagnosis. However, it is important to recognize the atypical clinical problems of monkeypox. In this article, the authors discuss the psychiatric manifestations of monkeypox, a clinical issue that is somewhat addressed. In brief, mental problems are possible in monkeypox. The mental disorder might be the first clinical presentation. In rare cases, patients might have confusion and it is difficult to diagnose. Awareness of the problem is needed. Additionally, the stigma is an important problem for patients with monkeypox. Some patients might have suicidal attempts. Therefore, it is necessary to have good mental health monitoring and support for patients with monkeypox. Last, similar to the previous COVID-19 situation, the influx of new data on monkeypox has occurred and it might be the cause of panic for general people. It is necessary to prepare for control of fake news and provide mental health support to the general public during the outbreak of monkeypox.

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“…These include feeling incompetent at work; seeing patients in pain; discomfort from wearing personal protective equipment (PPE) clothing; and long working hours, which may affect social relationships. All of these make the managers of health institutions pay special attention to nurses and healthcare workers, such as physical and psychological support; providing welfare services; more training opportunities; the use of modern technology; and protecting nurses during disease [ [10] , [11] ].…”

mentioning

confidence: 99%

The 2022 monkeypox outbreak — Special attention to nurses’ protection should be a top priority

Ibrahim

Abdulrahman

Ali

et al. 2022

Annals of Medicine &Amp; Surgery

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Timely mental health care for the 2022 novel monkeypox outbreak is urgently needed

Cited by 20 publications

References 7 publications

A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions

A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions

Monkeypox and Psychotic Manifestations: Possible But Little Recognized Clinical Manifestations

The 2022 monkeypox outbreak — Special attention to nurses’ protection should be a top priority

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