Timeline, Epidemiology, and Risk Factors for Bacterial, Fungal, and Viral Infections in Children and Adolescents after Allogeneic Hematopoietic Stem Cell Transplantation

Abstract

Advances made in the field of hematopoietic stem cell transplantations (HSCT) over the past 20 years may have had an impact on the distribution of posttransplantation infections. We sought to retrospectively analyze the epidemiology and risk factors for bacterial, fungal, and viral infections in children after allogeneic HSCT in a cohort of 759 children who underwent allogeneic HSCT in a single institution between 1990 and 2009. The association between infections and risk factors of interest at 0 to 30 days, 31 to 100 days, and 101 days to 2 years posttransplantation was evaluated using logistic regression. Difference among the subtypes within each category was studied. There were 243 matched-related donors, 239 matched-unrelated donors (MUDs), and 176 haploidentical donor transplantations. Era of transplantation (0–30 days), peripheral blood stem cell product, acute graft-versus-host disease (aGVHD; 31–100 days), and chronic GVHD (cGVHD; 101–730 days) were associated with higher risk for bacterial infections at the respective time periods. Patients with aGVHD (31–100 days), cGVHD, and older age (101–730 days) were at higher risk for fungal infections. Cytomegalovirus (CMV) donor/recipient (D/R) serostatus (0–100 days), era of transplantation, MUD HSCT (31–100 days), and cGVHD (101–730 days), influenced viral infections. Gram-positive outnumbered gramnegative bacterial infections; aspergillosis and candidemia were equally prevalent in all time periods. Haploidentical donor HSCT was not associated with an increased risk of infections. There seems to be a continuum in the timeline of infections posttransplantation, with bacterial, fungal, and viral infections prevalent in all time periods, particularly late after the transplantation, the risk affected by GVHD, CMV, D/R status, product type, older age, and use of unrelated donors.

Predictors of invasive fungal infection in pediatric allogeneic hematopoietic SCT recipients

“…[1][2][3][4][5][6][7][8][9][10] Based on prior studies, IFI is estimated to occur in 8-17% of pediatric HSCT patients, with a mortality rate of 35-50%. [1][2][3][4][5][6] Incidence varies in the different post-transplant phases, with peaks both pre-and post-engraftment.…”

“…[1][2][3][4][5][6] Post-HSCT, GVHD, viral reactivations and use of high-dose steroids are possibly related to the occurrence of IFI. [1][2][3][4][5][6][7][8][9][10] However, studies that focus on pediatric patients are scarce, use relatively small cohorts and are possibly outdated as advances in prophylactic and diagnostic strategies have been made. Therefore, we performed a risk factor analysis on a large cohort of pediatric patients from a single center.…”

Photochemotherapy of Cutaneous Graft-versus-Host Disease May Reduce Concomitant Visceral Disease

“…In aGvHD, the host antigens are presented not only in the skin treated by photochemotherapy but also in the visceral tissues affected by GvHD, yet, little is known of the suppressive effects of photochemotherapy beyond the skin. aGvHD is caused by the expansion of immune cells reactive against the immunosuppressed host, and the disease is accompanied by opportunistic viral and fungal infections [9]. This makes the visceral aGvHD difficult to diagnose, even more so since pharmacological toxicity is frequent in the population and has to be ruled out [10].…”

Profilaktyka zakażeń grzybiczych u dzieci poddawanych transplantacjom komórek hematopoetycznych

“…W tej grupie pacjentów naturalne mechanizmy odporności są drastycznie zmniejszone przez chorobę podstawową, kondycjonowanie oraz profilaktykę i leczenie choroby przeszczep przeciwko gospodarzowi [1,2]. W populacji pediatrycznej ryzyko wystąpienia inwazyjnego zakażenia grzybiczego jest szacowane na 8-17%, a śmiertelność waha się od 35 do 50% [1][2][3][4]. W roku 2014 Styczyński i wsp.…”