Timed Up and Go in men and women with Multiple Sclerosis: Effect of muscular strength

Casu, Giulia; Porta, Micaela; Pilloni, Giuseppina; Frau, Jessica; Coghe, Giancarlo; Cocco, Eleonora

doi:10.1016/j.jbmt.2020.06.014

Cited by 11 publications

(7 citation statements)

References 55 publications

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“…Patients fulfilling the eligibility criteria will be randomised into one of three groups with stratified blocked randomisation performed by an independent researcher at centre 1 using an online software-based random number generator (Sealed Envelope, London, UK), blocks of prespecified size and 1:1:1 allocation. Stratification will be performed according to relevant predictive factors for a change in walking that is,38 age (<40, ≥40), gender (female, male)39 40 and disability (Expanded Disability Status Scale41 2.0–3.5, 4.0–5.0). Sequentially numbered sealed opaque envelopes including group allocation numbers for groups 1–3 will be fabricated for each stratum.…”

Section: Methods and Analysesmentioning

confidence: 99%

Effects of actual and imagined music-cued gait training on motor functioning and brain activity in people with multiple sclerosis: protocol of a randomised parallel multicentre trial

et al. 2022

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IntroductionMotor imagery (MI) refers to the mental rehearsal of a physical action without muscular activity. Our previous studies showed that MI combined with rhythmic-auditory cues improved walking, fatigue and quality of life (QoL) in people with multiple sclerosis (pwMS). Largest improvements were seen after music and verbally cued MI. It is unclear whether actual cued gait training achieves similar effects on walking as cued MI in pwMS. Furthermore, in pwMS it is unknown whether any of these interventions leads to changes in brain activation. The purpose of this study is therefore to compare the effects of imagined and actual cued gait training and a combination thereof on walking, brain activation patterns, fatigue, cognitive and emotional functioning in pwMS.Methods and analysisA prospective double-blind randomised parallel multicentre trial will be conducted in 132 pwMS with mild to moderate disability. Randomised into three groups, participants will receive music, metronome and verbal cueing, plus MI of walking (1), MI combined with actual gait training (2) or actual gait training (3) for 30 min, 4× per week for 4 weeks. Supported by weekly phone calls, participants will practise at home, guided by recorded instructions. Primary endpoints will be walking speed (Timed 25-Foot Walk) and distance (2 min Walk Test). Secondary endpoints will be brain activation patterns, fatigue, QoL, MI ability, anxiety, depression, cognitive functioning, music-induced motivation-to-move, pleasure, arousal and self-efficacy. Data will be collected at baseline, postintervention and 3-month follow-up. MRI reference values will be generated using 15 matched healthy controls.Ethics and disseminationThis study follows the Standard Protocol Items: Recommendations for Interventional Trials-PRO Extension. Ethical approval was received from the Ethics Committees of the Medical Universities of Innsbruck (1347/2020) and Graz (33-056 ex 20/21), Austria. Results will be disseminated via national and international conferences and published in peer-reviewed journals.Trial registration numberDRKS00023978.

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Section: Methods and Analysesmentioning

confidence: 99%

Effects of actual and imagined music-cued gait training on motor functioning and brain activity in people with multiple sclerosis: protocol of a randomised parallel multicentre trial

et al. 2022

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“…The score obtained (from 0 to 100) indicates the degree of disability (0 = absence of disability; 100 = maximum disability) [ 55 ]; Berg Balance Scale, comprising 14 tests, each rated from 0 to 4; the sum of the scores indicates the balance level [ 56 ]; Timed Up and Go Test (TUG), to assess the risk of falling. The patient, starting from the sitting position, is instructed to get up on the therapist’s instructions, to walk three meters, to turn on himself or around an obstacle, return to the chair, and sit down [ 57 ]; Ten Meter Walk Test (10MWT), to evaluate the walking speed in meters per second over ten meters [ 58 ]; Fatigue Severity Scale (FSS), a one-dimensional nine-item questionnaire that collects information on the severity and impact on the quality of life of MS fatigue through a seven-point Likert-type scale [ 59 ]; European Quality of life—five dimensions—three levels (EQ5D3L) index and EQVAS, a self-administered questionnaire consisting of two different parts. The first one explores five dimensions of interest, such as mobility, personal hygiene, social activities, pain, and anxiety/depression; every single dimension provides three levels of severity (no problem, problem of some entity, problem of extreme gravity).…”

Section: Case Presentationmentioning

confidence: 99%

“…Timed Up and Go Test (TUG), to assess the risk of falling. The patient, starting from the sitting position, is instructed to get up on the therapist’s instructions, to walk three meters, to turn on himself or around an obstacle, return to the chair, and sit down [ 57 ];…”

Section: Case Presentationmentioning

confidence: 99%

Ultrasound-Guided Injections and Proprioceptive Neuromuscular Facilitation as Shoulder Rehabilitation for Multiple Sclerosis and Neuropathic Pain

et al. 2022

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Multiple sclerosis (MS) represents a major cause of chronic neurological disability in young adults and can result in upper limb sensorimotor impairment with a huge impact on manual dexterity and activities of daily living. Moreover, pain is common in MS and a large proportion of patients suffer from central neuropathic pain. To date, no rehabilitative treatment has been described as useful for these patients. A 46-year-old woman, affected by relapsing-remittent MS, described a one-year history of right shoulder pain (Visual Analogue Scale = 8) that started gradually and without trauma. The patient also presented balance and gait impairments, upper limb strength deficit, and fatigue (Expanded Disability Status Scale = 5.5). A multidisciplinary treatment was proposed, including three intra-articular corticosteroid injections and one month of manual therapy, three sessions/week, based on proprioceptive neuromuscular facilitation for the upper limb. At the end of the rehabilitative treatment, pain relief and an improvement in the range of motion of the affected shoulder, upper limb muscle strength, and hand dexterity were observed. The present paradigmatic case report with literature review demonstrated that a multidisciplinary approach seems to be effective in pain relief in a patient with central neuropathic shoulder pain and relapsing-remitting MS.

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“…It is estimated that every 5 min someone is diagnosed with MS globally ( 1 ). Despite the unpredictable and varying symptoms of the disease, one of the most clinically relevant and common complaints in this population is muscular weakness and loss of motor function ( 2 ). In most cases, rudimentary tasks such as bathing and feeding become increasingly more difficult.…”

Section: Introductionmentioning

confidence: 99%

Adaptations in Muscular Strength for Individuals With Multiple Sclerosis Following Robotic Rehabilitation: A Scoping Review

Mannella¹,

Cudlip²,

Holmes³

2022

Front. Rehabilit. Sci.

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Muscular weakness and loss of motor function are common symptoms of multiple sclerosis. Robotic rehabilitation can improve sensorimotor function and motor control in this population. However, many studies using robotics for rehabilitation have overlooked changes in muscular strength, despite research demonstrating its utility in combating functional impairments. The purpose of this scoping review was to critically examine changes in muscular strength following robotic rehabilitation interventions for individuals with multiple sclerosis. A literature search of five databases was conducted and search terms included a combination of three primary terms: robotic rehabilitation/training, muscular strength, and multiple sclerosis. Thirty one articles were found, and following inclusion criteria, 5 remained for further investigation. Although muscular strength was not the primary targeted outcome of the training for any of the included articles, increases in muscular strength were present in most of the studies suggesting that robotic therapy with a resistive load can be an effective alternative to resistance training for increasing muscular strength. Outcome measures of isometric knee-extensor force (kg) (right: p < 0.05, left: p < 0.05), isometric knee flexion and extension torque (Nm) (p < 0.05), ankle dorsiflexion and plantarflexion torque (Nm) (all p < 0.05) and handgrip force (kg) (p < 0.05) all improved following a robotic training intervention. These adaptations occurred with sustained low resistive loads of hand grip or during gait training. This scoping review concludes that, despite a lack of studies focusing on strength, there is evidence robotics is a useful modality to improve muscular strength in combination with motor control and neuromotor improvements. A call for more studies to document changes in strength during robotic rehabilitation protocols is warranted.

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Timed Up and Go in men and women with Multiple Sclerosis: Effect of muscular strength

Cited by 11 publications

References 55 publications

Effects of actual and imagined music-cued gait training on motor functioning and brain activity in people with multiple sclerosis: protocol of a randomised parallel multicentre trial

Effects of actual and imagined music-cued gait training on motor functioning and brain activity in people with multiple sclerosis: protocol of a randomised parallel multicentre trial

Ultrasound-Guided Injections and Proprioceptive Neuromuscular Facilitation as Shoulder Rehabilitation for Multiple Sclerosis and Neuropathic Pain

Adaptations in Muscular Strength for Individuals With Multiple Sclerosis Following Robotic Rehabilitation: A Scoping Review

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