Timed‐Release Depot for Anticancer Agents

Yolles, S.; Leafe, Thomas D.; Meyer, Francis J.

doi:10.1002/jps.2600640124

Cited by 47 publications

(21 citation statements)

References 4 publications

(3 reference statements)

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confidence: 99%

“…The delivery devices were either drug loaded films with or without plastization by tributyl citrate or drug loaded polymer powders suspended in a dispersing agent (5)(6)(7)(8). In continuation of this work the application of poly(L-lactide) was extended to a number of different drugs (9,10). Poly(L-lactide) and racemic poly(lactide) were later used for the controlled delivery of contraceptives in form of monolithic devices (11) or as reservoir devices prepared by microencapsulation techniques (12,13) for the delivery of narcotic antagonists.…”

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confidence: 99%

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Biodegradable Polymers for Sustained Drug Delivery

Schindler

Jeffcoat

Kimmel

et al. 1977

Contemporary Topics in Polymer Science

180

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SYNOPSISMost studies of the sustained release of drugs from subdermally implanted polymer devices have centered on the use of silicone rubber. However, the use of this polymer has serious limitations because of its nonbiodegradability. The depleted capsule has to be surgically removed if one is to eliminate potential problems associated with non-degradable foreign substances remaining in the body for an indefinite length of time. The development of polymer systems which combine the release properties of silicone rubber with biodegradability will represent a significant advance in the technique of controlled release of contraceptives. The polymer system selected for Dur investigations were polyesters comprising homo and copolymers of glycolide, dilactide, s-caprolactone, and s-decalactone. These polymers were found to undergo random hydrolytic degradation under in vitro and in vivo conditions. The polymers were characterized by their rates of biodegradation and their release parameters for contraceptive steroids. Long time release rates of steroids from monolithic and reservoir devices were determined. Especially poly(scaprolactone) was found to come close to meeting the requirements of a biodegradable reservoir device for controlled drug delivery, with a useful lifespan approaching one year. Copolymers of s-caprolactone and racemic dilactide are more permeable than poly(s-caprolactone) and are of value for biodegradable devices with shorter than one year lifespan.

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confidence: 99%

mentioning

confidence: 99%

Biodegradable Polymers for Sustained Drug Delivery

Schindler

Jeffcoat

Kimmel

et al. 1977

Contemporary Topics in Polymer Science

180

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“…In this study, EPLA and CPLA were synthesized and their structures were characterized by FTIR, 1 H NMR, and FITC-labeled fluorescence spectra. Results showed that the hydrophilicity of CPLA was significantly higher than PLA and there was no obvious acid-catalyzed self-accelerating degradation behavior in the degradation process of CPLA.…”

Section: Discussionmentioning

confidence: 99%

“…By the reaction between diamine on modified PLA and the hydroxyl group/carboxyl groups on collagen with DCC as a condensing agent, the collagen-modified PLA (CPLA) was synthesized. Their structure was characterized by FTIR, 1 H NMR, and fluorescein isothiocyanate (FITC)-labeled fluorescence spectra. Then, some properties of CPLA, such as hydrophilicity and degradability, were characterized.…”

Section: Introductionmentioning

confidence: 99%

Study on synthesis and application of collagen‐modified polylactic acid

Liu

Xiao

et al. 2014

Polymer Composites

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To modify the degradability and improve the hydrophilicity of polylactic acid (PLA), collagen-modified polylactide (CPLA) was synthesized by means of grafting modification method including chloridization and aminolysis, and its structure was characterized by FTIR, 1 H NMR, and fluorescein isothiocyanate-labeled fluorescence spectra. Subsequently, the hydrophilicity and degradation behavior of CPLA were characterized. Finally, CPLA was used as a carrier for the preparation of the trypsin sustained release microspheres via the emulsion-solvent evaporation technique, followed with its characterization. Results showed that the collagen had been grafted into PLA and the graft ratio of collagen measured about 6.7%. Water absorption behavior test indicated that the hydrophilicity of CPLA was significantly higher than PLA. Furthermore, degradability test revealed that the degradation behavior of PLA was obviously modified and there was no obvious acidcatalyzed self-accelerating degradation behavior in the degradation process of CPLA. It was also indicated that the encapsulation efficiency and drug content in trypsin-loaded CPLA microspheres were all clearly higher than trypsin-loaded PLA microspheres. The results suggested that CPLA showed a great potential as matrix for drug delivery. POLYM. COMPOS., 36:88-93, 2015.

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“…Other polymers include polyorthoesters, poly( e -caprolactone) and polyamino acids. Bioerodible drug delivery systems based on polylactic acid and lactic/glycolic copolymers have been investigated in areas of application such as steroidal contraceptives (Wise et al, 1980), narcotic antagonists (Yolles et al, 1974), antimalarials (Wise et al, 1979), and anticancer agents (Yolles et al, 1975). The forms in which these delivery systems have been studied include implantable cylinders, spheres, films, and powdered formulations.…”

Section: Bioerodible Systemsmentioning

confidence: 99%

Development of an ocular drug release system for cattle

Dinh

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Timed‐Release Depot for Anticancer Agents

Cited by 47 publications

References 4 publications

Biodegradable Polymers for Sustained Drug Delivery

Biodegradable Polymers for Sustained Drug Delivery

Study on synthesis and application of collagen‐modified polylactic acid

Development of an ocular drug release system for cattle

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