Time will tell about mast cells: Circadian control of mast cell activation

Nakao, Akihiro; Nakamura, Yuki

doi:10.1016/j.alit.2022.06.008

Cited by 10 publications

(6 citation statements)

References 50 publications

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“…The mean age of our patients was 35.86 years, which was a similar finding in other studies [8,14,15]. In our study, the mean duration of the disease was 35 27 years, which was quite similar to an Indian study in which the mean duration of CU was 40 ± 40.93 months, and ranged from two months to twenty years [15].…”

Section: Discussionsupporting

confidence: 90%

“…The signs and symptoms of CSU may occur spontaneously at any time of the day yet commonly during the evening, among 22 (29.3%) patients with CSU and 3 (17.6%) with CINDU, and at night (1; 5.8%), which was less than in a study from Europe (evening: 34%; night: 23%) [34]. The appearance of wheals during the evening and night may reflect the circadian variation in mast cell activation, which is crucial in developing allergic diseases [34,35].…”

Section: Discussionmentioning

confidence: 96%

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Socio-demographic and clinical characteristics of chronic urticaria among patients attending Dermatology Clinic in a Tertiary Care Hospital

Gyawalee¹,

Paudel²

2023

Our Dermatol Online

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Background: Chronic urticaria (CU) is characterized as the recurrent occurrence of wheals, angioedema, or both on most days of the week, for more than six weeks. Information available on this disease is mainly based on foreign studies. We observed the clinical characteristics of this disease among our population to fill the shortage of information. Materials and Methods: It was a hospital-based, cross-sectional, descriptive study conducted at the Department of Dermatology from July 2022 to March 2023. Patients diagnosed with CU were enrolled in this study after obtaining ethical approval from the Institutional Review Committee (IRC). The calculated sample size was 123. Sociodemographic features and clinical characteristics were recorded after taking consent from the patients. A descriptive analysis was performed and presented in frequency tables. Results: The majority (61%) had chronic spontaneous urticaria (CSU), 13.8% had chronic inducible urticaria (CINDU), and 25.2% had both CSU and CINDU. The mean age of participants was 35.86 ± 13.45 years. Females comprised 72.4% of the patients. A family history of urticaria was found in 16.2% of patients. The mean disease duration was 35.88 ± 60.2 months. Wheals occurred in the evening in 24.3% of cases. Angioedema was reported by 18.6% of the patients. Gastritis was the most common (11.4%) comorbidity. Physical factors precipitated urticaria in 39% of cases. Recurrence of the disease was seen in 17.8%. Prior to visiting the dermatologist, 76.4% had been taking antihistamines and 15% attempting an alternative medicine. Conclusion: Our findings were consistent with those of previous reports. CSU is more than three times more common than CINDU. Females and young adults were more affected by CU. Concomitant CSU and CINDU is also possible. As a chronic condition, it is often difficult to manage, and patients tend to explore alternative options. Key words: Chronic urticaria, Clinical, Demography, Descriptive study

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 96%

Socio-demographic and clinical characteristics of chronic urticaria among patients attending Dermatology Clinic in a Tertiary Care Hospital

Gyawalee¹,

Paudel²

2023

Our Dermatol Online

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“…Most patients with CSU present with only wheals (~57%), whereas the occurrence of wheals and angioedema (~37%) or only angioedema (~6%) is less common (see Supplementary Table 8). The signs and symptoms of CSU can occur spontaneously at any time of the day but commonly during the evening and night 109 , which may reflect circadian variations in mast cell activation 110 and differences in the underlying pathogenesis. For example, the presence of nocturnal symptoms has been associated with an autoimmune endotype of CSU 111 .…”

Section: Chronic Spontaneous Urticariamentioning

confidence: 99%

Urticaria

Kolkhir

Giménez‐Arnau

Kulthanan

et al. 2022

Nat Rev Dis Primers

157

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“…Circadian genes play important roles in regulating the cascade of inflammatory gene expression in allergic diseases and ALAN-induced disruption of these genes may trigger proinflammatory responses, such as allergic reactions. Apart from direct control, several studies have shown that allergic diseases also have circadian rhythmicity [25][26][27][28][29]; for example, asthma and other allergic diseases such as allergic rhinitis and atopic dermatitis are known to have marked variations in symptoms at different times of the day due to underlying rhythmic inflammatory pathways [30][31][32][33][34]. Allergic diseases, including asthma, are very common chronic inflammatory diseases, affecting at least 8 to 10% of the global population [35].…”

Section: Introductionmentioning

confidence: 99%

Influence of light at night on allergic diseases: a systematic review and meta-analysis

Deprato,

Maidstone,

Cros

et al. 2024

BMC Med

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Background Allergic diseases impose a significant global disease burden, however, the influence of light at night exposure on these diseases in humans has not been comprehensively assessed. We aimed to summarize available evidence considering the association between light at night exposure and major allergic diseases through a systematic review and meta-analysis. Methods We completed a search of six databases, two registries, and Google Scholar from inception until December 15, 2023, and included studies that investigated the influence of artificial light at night (ALAN, high vs. low exposure), chronotype (evening vs. morning chronotype), or shift work (night vs. day shift work) on allergic disease outcomes (asthma, allergic rhinitis, and skin allergies). We performed inverse-variance random-effects meta-analyses to examine the association between the exposures (ALAN exposure, chronotype, or shiftwork) and these allergic outcomes. Stratification analyses were conducted by exposure type, disease type, participant age, and geographical location along with sensitivity analyses to assess publication bias. Results We included 12 publications in our review. We found that exposure to light at night was associated with higher odds of allergic diseases, with the strongest association observed for ALAN exposure (OR: 1.88; 95% CI: 1.04 to 3.39), followed by evening chronotype (OR: 1.35; 95% CI: 0.98 to 1.87) and exposure to night shift work (OR: 1.33; 95% CI: 1.06 to 1.67). When analyses were stratified by disease types, light at night exposure was significantly associated with asthma (OR: 1.62; 95% CI: 1.19 to 2.20), allergic rhinitis (OR: 1.89; 95% CI: 1.60 to 2.24), and skin allergies (OR: 1.11; 95% CI: 1.09 to 1.91). We also found that the association between light at night exposure and allergic diseases was more profound in youth (OR: 1.63; 95% CI: 1.07 to 2.48) than adults (OR: 1.30; 95% CI: 1.03 to 1.63). Additionally, we observed significant geographical variations in the association between light at night exposure and allergic diseases. Conclusions Light at night exposure was associated with a higher prevalence of allergic diseases, both in youth and adults. More long-term epidemiological and mechanistic research is required to understand the possible interactions between light at night and allergic diseases.

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Time will tell about mast cells: Circadian control of mast cell activation

Cited by 10 publications

References 50 publications

Socio-demographic and clinical characteristics of chronic urticaria among patients attending Dermatology Clinic in a Tertiary Care Hospital

Socio-demographic and clinical characteristics of chronic urticaria among patients attending Dermatology Clinic in a Tertiary Care Hospital

Urticaria

Influence of light at night on allergic diseases: a systematic review and meta-analysis

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