Time-Varying Outcomes Associated With Maternal Age at First Birth

A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex

“…The single strongest predictor of advanced parental age, particularly for mothers, was PS EA . We confirmed in our dataset a significant correlation of parental education and parental age 47 that was stronger for mothers ( r 2 = 0.06, P = 3.5 × 10 −52 ; Supplementary Table 19 ) than for fathers ( r 2 = 0.03, P = 1.3 × 10 −23 ). By contrast, measures of social impairment in parents (SRS, BAPQ) were not associated with advanced parental age.…”

A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex

“…For example, a genetic predictor of high educational attainment (PSEA) is associated with later parenthood, particularly for women. We confirmed in our dataset that education and parental age 41 334 were more strongly correlated for mothers (r 2 = 0.06, p = 3.5x10 -52 ) than for fathers (r 2 = 0.03 p=1.3x10 -23 ). Thus, inherited mechanisms of maternal-age effects may involve a 336 dependency between the level of education a woman seeks and the age at which she 337 has children.…”

Home Improvement: Evaluating Secular Changes in NLSY HOME-Cognitive Stimulation and Emotional Support Scores

“…Our primary hypothesis, that there would be a general improvement in the home environment, and that the improvement would be similar in magnitude to the Flynn effect, were largely supported: scores have increased, and they have increased at a rate comparable to the Flynn effect (approximately 0.02 SD per year, or a raw effect size greater than at least 0.3, Table 5). Furthermore, that increase can be attributed specifically to mother's age at first birth (or related variables, although most of the related variables are also controlled as well), similar to previous findings (e.g., Fulco et al, 2019;O'Keefe & Rodgers, 2017). The increasing patterns are found primarily for infants and younger children.…”

“…Of further interest, it is worth putting our results in the context of prior research. Fulco et al (2019), found that the HOME was related to maternal age at first birth, just as we have. In our context we have linked a longitudinal improvement in the home environment to maternal age at first birth.…”

“…Further refining our hypothesis, research by O'Keefe and Rodgers (2017), using the same source of data as used here, found that the Flynn effect may be a largely family-based effect, and perhaps linked to mother's age at first birth. Similarly, Fulco et al (2019) found that mother's age at first birth was linked to a measure of the home environment, also in this source of data. On the basis of these two studies we would predict that, if we find a longitudinal increase it is likely to be linked to mother's age at first birth.…”