Time-varying mediation analysis for incomplete data with application to DNA methylation study for PTSD
Kecheng Wei,
Fei Xue,
Qi Xu
et al.
Abstract:DNA methylation (DNAm) has been shown to mediate causal effects from traumatic experiences to post-traumatic stress disorder (PTSD). However, the scientific question about whether the mediation effect changes over time remains unclear. In this paper, we develop time-varying structural equation models to identify cytosine-phosphate-guanine (CpG) sites where DNAm mediates the effect of trauma exposure on PTSD, and to capture dynamic changes in mediation effects. The proposed methodology is motivated by the Detro… Show more
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