Time trends of colorectal cancer incidence and associated lifestyle factors in South Korea

Khil, Hayeong; Kim, Sung Min; Hong, Sung‐Eun; Gil, Hyeon Min; Cheon, Eugene; Lee, Dong Hoon; Kim, Young Ae; Keum, NaNa

doi:10.1038/s41598-021-81877-2

Cited by 51 publications

(44 citation statements)

References 39 publications

(64 reference statements)

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“…The same gender difference was seen in previous study in China, 16 Canada 17 and South Korea. 18 Smoking, obesity, alcohol drinking and physical inactivity appeared to be more relevant CRC contributor to men. 15 , 18 , 19 Commonly, Chinese men smoke more frequently than women.…”

Section: Discussionmentioning

confidence: 95%

“… 18 Smoking, obesity, alcohol drinking and physical inactivity appeared to be more relevant CRC contributor to men. 15 , 18 , 19 Commonly, Chinese men smoke more frequently than women. 20 , 21 Furthermore, research results 19 showed that the transverse colon length of women was longer than that of men in colonoscopy, leading to a lower sensitivity to colorectal cancer screening in women.…”

Section: Discussionmentioning

confidence: 95%

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Colorectal Cancer Incidence and Mortality Trends and Analysis of Risk Factors in China from 2005 to 2015

Sun¹,

Liu²,

Huang³

et al. 2021

IJGM

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Purpose This study aimed to analyze incidence and mortality trends and risk factors of colorectal cancer (CRC) in China during 2005–2015. Materials and Methods Patient cases were extracted from the Chinese Cancer Registry Annual Report. Joinpoint regression and Poisson regression were applied to analyze incidence and mortality trends and risk factors of CRC. Age-period-cohort model was used to evaluate the age, period and cohort effects on CRC. Results The standardized incidence and mortality rate of CRC in China showed a decreasing trend during 2005–2015. The incidence in men (APC=−1.22%, P<0.05) decreased from 2005 to 2015 and decreased in women (APC =−3.55%, P<0.05) from 2005 to 2013, then increased during 2013–2015 (APC =18.77%, P<0.05). The incidence and mortality in urban areas were higher than those in rural (The incidence in urban: APC =−0.97%, P<0.05; rural: APC =1.94%, P<0.05; the mortality in urban: APC =−0.67%, P<0.05; rural: APC =0.29%). For age-specific rates, the incidence begins to increase significantly at 40–45 age group and reached a peak at 75; the mortality increased significantly at 45–50. The age effect increased with age in general. The 1920 birth cohort had the highest risk of colorectal cancer incidence and death. Poisson regression showed region, gender and age were independent risk factors of CRC. Conclusion The age-adjusted standardized incidence rate (ASIR) and age-adjusted standardized mortality rate (ASMR) of CRC in China during 2005–2015 were decreasing. A great concern on men, rural areas and people aged over 75 should be aroused to prevent colorectal cancer.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

Colorectal Cancer Incidence and Mortality Trends and Analysis of Risk Factors in China from 2005 to 2015

Sun¹,

Liu²,

Huang³

et al. 2021

IJGM

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“…Colorectal cancer (CRC) is a common and life-threatening disease worldwide [ 1 ], with Asia contributing the highest, 1, 009,400 (52.3%) of incident cases and 506, 499 (54.2%) of deaths in 2020 [ 2 ]. South Korea in 2018 had the second highest incidence rate of CRC in Asia, with currently positioning it at the fourth most common cause of cancer death [ 3 , 4 ]. Many population data reported that approximately 30–40% of CRC cases occur in patients aged above 75 years [ 1 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Operative and Survival Outcomes of Robotic-Assisted Surgery for Colorectal Cancer in Elderly and Very Elderly Patients: A Study in a Tertiary Hospital in South Korea

Cuellar-Gomez

Rusli

Ocharan-Hernández

et al. 2022

Journal of Oncology

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Introduction and Objectives. Most patients with colorectal cancer are elderly. Literature is scarce on elderly patients submitted to robotic-assisted surgery, despite the feasibility shown in other age groups. The aim of this study was to evaluate the postoperative and survival outcomes of robotic-assisted colorectal cancer surgery in elderly patients. Materials and Methods. Data of all patients ≥75 years who underwent a robotic-assisted curative resection in Korea University Anam Hospital, Seoul, South Korea, between January 2007 and January 2021 were extracted from a prospectively maintained colorectal cancer database. Patients were subdivided into the three groups according to the age: youngest-old (YO: 75–80 years), middle-old (MO: 81–85), and oldest-old (OO: ≥86 years). Intraoperative findings, postoperative, and oncological outcomes were compared between the groups. Results. Seventy-six consecutive patients (female 52.6%) were included; mean age was 80 years (SD 0.33); mean body mass index (BMI), 23.8 20.9 kg/m2 (SD 3.58); mean total operative time, 279 min (SD 80.93); mean blood loss, 186 ml (SD 204.03); mean postoperative length of stay, 14 days (SD 12.03). Major complications were seen in 2.1% of patients. The 30-day mortality rate was 0%. Average number of lymph node harvested was 20.9 (SD 12.33). Postoperative complications were not statistically different between the groups. Mean follow-up time for cancer-specific survival (CSS) was 99.28 months for the YO, 72.11 months for MO, and 31.25 months for OO groups ( p = 0.045). The CSS rates at 5 years were 27.0%, 21.0%, and 0%, respectively. Recurrence risk was 10.50 times higher in the OO group than the others (adjusted HR, 95% CI 1.868–59.047, p = 0.008). In the multivariable analysis, TNM stage was not a risk factor for CSS in all groups. The number of the harvested nodes was a protective factor for recurrence (HR of 0.932, 95% CI 0.875–0.992, p = 0.027) and CSS (HR of 0.928, 95% CI 0.861–0.999, p = 0.047) in elderly patients. Conclusion. Robotic surgery is highly feasible in elderly and very elderly colorectal cancer patients, providing a favorable operative safety profile and an acceptable cancer-specific survival outcome.

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“…In 2020, 1.9 million cases of CRC were estimated worldwide [1]. In particular, South Korea had the second highest incidence rate of CRC in the world, as of 2018 [2]. Considering this increasing prevalence, accurate prediction of prognosis in patients with CRC after treatment is now essential.…”

Section: Introductionmentioning

confidence: 99%

The Clinical Impact of Combining Neutrophil-to-Lymphocyte Ratio with Sarcopenia for Improved Discrimination of Progression-Free Survival in Patients with Colorectal Cancer

Lee

Chung

Cho

et al. 2022

JCM

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This study aimed to evaluate the clinical impact of combined sarcopenia and inflammation classification (CSIC) in patients with colorectal cancer (CRC). The skeletal muscle index (SMI) and neutrophil-to-lymphocyte ratio (NLR) were measured in 1270 patients who underwent surgery between January 2005 and April 2014. A Cox proportional hazards model was used to evaluate the correlation of sarcopenia, NLR, and CSIC, with progression-free survival (PFS). The integrated area under the curve (iAUC) was used to compare the discriminatory performance of each model. Using the cut-off values for SMI suggested by Martin et al. and for an NLR of 2.26, the CSIC was defined as follows: nonsarcopenia with low NLR (group 1), nonsarcopenia with high NLR (group 2), sarcopenia with low NLR (group 3), and sarcopenia with high NLR (group 4). Sarcopenia alone was not statistically significant. Multivariate analysis identified that CSIC (group 4 vs. group 1; hazard ratio (HR), 1.726; 95% CI, 1.130–2.634; p = 0.011) and NLR (HR, 1.600; 95% CI, 1.203–2.128; p = 0.001) were independently associated with PFS. The CSIC improved the prediction accuracy of PFS compared with NLR (iAUC mean difference = 0.011; 95% CI, 0.0018–0.028). In conclusion, the combination of sarcopenia and NLR could improve prognostic accuracy, and thus compensate for the limitation of sarcopenia.

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Time trends of colorectal cancer incidence and associated lifestyle factors in South Korea

Cited by 51 publications

References 39 publications

Colorectal Cancer Incidence and Mortality Trends and Analysis of Risk Factors in China from 2005 to 2015

Colorectal Cancer Incidence and Mortality Trends and Analysis of Risk Factors in China from 2005 to 2015

Operative and Survival Outcomes of Robotic-Assisted Surgery for Colorectal Cancer in Elderly and Very Elderly Patients: A Study in a Tertiary Hospital in South Korea

The Clinical Impact of Combining Neutrophil-to-Lymphocyte Ratio with Sarcopenia for Improved Discrimination of Progression-Free Survival in Patients with Colorectal Cancer

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