Time trends in upper gastrointestinal diseases and <i>Helicobacter pylori</i> infection in a multiracial Asian population – a 20‐year experience over three time periods

Leow, Alex Hwong Ruey; Lim, Yat-Yuen; Liew, W.‐C.; Goh, Khean‐Lee

doi:10.1111/apt.13550

Cited by 53 publications

(40 citation statements)

References 15 publications

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“…However, the prevalence of H. pylori infection is low in our local population. A recent time‐trend study reported that the prevalence of H. pylori infection has reduced from 51.7% to 11.1% over the last 20 years, hence we believe that a concomitant H. pylori infection would not have influenced our results. The study was conducted in a single center only, hence the findings may not be generalizable to other settings.…”

Section: Discussionmentioning

confidence: 76%

Dyspepsia in non‐steroidal anti‐inflammatory drug users and the effect of preventive measures

Lee

Chua

Mahadeva

2018

J of Digest Diseases

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Section: Discussionmentioning

confidence: 76%

Dyspepsia in non‐steroidal anti‐inflammatory drug users and the effect of preventive measures

Lee

Chua

Mahadeva

2018

J of Digest Diseases

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“…As a consequence, the prevalence of PUD is declining as well in these countries. Leow et al . confirmed this trend in a multiracial Asian population by analyzing the prevalence of upper GI pathologies in esophagogastroduodenal (EGD) records within three time periods: 1989–1990, 1999–2000, and 2009–2010, spanning a total period of 20 years.…”

Section: Helicobacter Pylori and Peptic Ulcer Diseasementioning

confidence: 87%

Helicobacter pylori and non‐malignant upper gastrointestinal diseases

2016

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Peptic ulcer disease (PUD) has been further decreased over the last decades along with decreasing prevalence of Helicobacter pylori-associated PUD. A delayed H. pylori eradication has been associated with an increased risk of rehospitalization for complicated recurrent peptic ulcer and reemphasized the importance of eradication especially in patients with peptic ulcer bleeding (PUB). PUB associated with NSAID/aspirin intake and H. pylori revealed an additive interaction in gastric pathophysiology which favors the "test-and-treat" strategy for H. pylori in patients with specific risk factors. The H. pylori-negative and NSAID-negative "idiopathic PUD" have been increasingly observed and associated with slower healing tendency, higher risk of recurrence, and greater mortality. Helicobacter pylori-associated dyspepsia has been further investigated and finally defined by the Kyoto consensus. Helicobacter pylori eradication therapy is advised as first option in this group of patients. Only in the case of symptom persistence or recurrence after eradication therapy, dyspeptic patients should be classified as functional dyspepsia (FD). There were few new data in 2015 on the role of H. pylori infection in gastroesophageal reflux disease (GERD), and in particular Barrett's esophagus. A lower prevalence of gastric atrophy with less acid output in patients with erosive esophagitis confirmed previous findings. In patients with erosive esophagitis, no difference was observed in healing rates neither between H. pylori-positive and H. pylori-negative patients nor between patients that underwent eradication therapy compared to patients without eradication. These findings are in line with the current consensus guidelines concluding that H. pylori eradication has no effects on symptoms and does not aggravate preexisting GERD.

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“…A number of reports from Malaysia have indicated a significant epidemiological change in upper gastrointestinal diseases including gastric and esophageal cancers . The findings mirror the West with a decline in gastric cancers, esophageal squamous cell carcinomas and H. pylori infection.…”

Section: Situation In Malaysiamentioning

confidence: 97%

Different time trend and management of esophagogastric junction adenocarcinoma in three Asian countries

Hatta

Tong

Lee

et al. 2017

Digestive Endoscopy

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Esophagogastric junction (EGJ) adenocarcinoma has been on the increase in Western countries. However, in Asian countries, data on the incidence of EGJ adenocarcinoma are evidently lacking. In the present review, we focus on the current clinical situation of EGJ adenocarcinoma in three Asian countries: Japan, Hong Kong, and Malaysia. The incidence of EGJ adenocarcinoma has been reported to be gradually increasing in Malaysia and Japan, whereas it has stabilized in Hong Kong. However, the number of cases in these countries is comparatively low compared with Western countries. A reason for the reported difference in the incidence and time trend of EGJ adenocarcinoma among the three countries may be explained by two distinct etiologies: one arising from chronic gastritis similar to distal gastric cancer, and the other related to gastroesophageal reflux disease similar to esophageal adenocarcinoma including Barrett's adenocarcinoma. This review also shows that there are several concerns in clinical practice for EGJ adenocarcinoma. In Hong Kong and Malaysia, many EGJ adenocarcinomas have been detected at a stage not amenable to endoscopic resection. In Japan, histological curability criteria for endoscopic resection cases have not been established. We suggest that an international collaborative study using the same definition of EGJ adenocarcinoma may be helpful not only for clarifying the characteristics of these cancers but also for improving the clinical outcome of these patients.

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Time trends in upper gastrointestinal diseases and Helicobacter pylori infection in a multiracial Asian population – a 20‐year experience over three time periods

Abstract: Peptic ulcers have declined significantly over a 20-year period together with a decline in H. pylori infection. In contrast, a steady increase in erosive oesophagitis was observed. Gastric and oesophageal squamous cell cancers have declined to low levels.

Cited by 53 publications

References 15 publications

Dyspepsia in non‐steroidal anti‐inflammatory drug users and the effect of preventive measures

Dyspepsia in non‐steroidal anti‐inflammatory drug users and the effect of preventive measures

Helicobacter pylori and non‐malignant upper gastrointestinal diseases

Different time trend and management of esophagogastric junction adenocarcinoma in three Asian countries

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