Time trends in prevalence of cervical cytological abnormality in women attending a sexually transmitted diseases clinic and their relationship to trends in sexual activity and specific infections

Armstrong, Bruce K.; Allen, Oenone; Brennan, Benjamin; Fruzynski, I A; Klerk, Nicholas de; Waters, Emily; Machin, Julie; Gollow, M M

doi:10.1038/bjc.1986.225

Cited by 19 publications

(3 citation statements)

References 8 publications

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“…To our knowledge, this is the first study to use molecular biological techniques to identify changes in the prevalence of HPV infection that might have occurred during the last two decades. All previous studies have been based on reviewing histological [Mazur and Cloud, 19841 or cytological [Armstrong et al, 1986;Alasio et al, 19891 material from hospital patients [Mazur and Cloud, 1984;Alasio et al, 19861 or patients of sexually transmitted disease clinics [Armstrong et al, 19861 and therefore are not necessarily representative of the general population.…”

Section: Discussionmentioning

confidence: 99%

Time trends in the prevalence of human papillomavirus infections in archival Papanicolaou smears: Analysis by cytology, DNA hybridization, and polymerase chain reaction

Rakoczy¹,

Sterrett²,

Kulski³

et al. 1990

Journal of Medical Virology

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A retrospective study was undertaken to determine the prevalence of human papillomavirus (HPV) infections in routine Papanicolaou (Pap) smears collected by general practitioners from Western Australian women in each of the years 1972, 1982, and 1987. HPV infection was detected by cytology, dot-blot hybridization, or polymerase chain reaction (PCR). It was found that the prevalence of HPV infection remained unchanged over the 15 year study period, was independent of age, and was associated with normal cytology at a rate far greater than previously recognized. Indeed, the prevalence of cervical intraepithelial neoplasia (CIN) lesions, as detected by cytology, was 3.0% in 1972 and 3.8% in 1982 and 1987. The prevalence of HPV infection, detected as koilocytosis or parakeratosis, was 6.5%, 6.8%, and 5.3% in smears collected in 1972, 1982, and 1987, respectively, from 1,800 women. In 237 cytologically normal smears reprocessed for HPV-DNA studies, the prevalence of HPV 16 was determined to be 15.6%, 11.2%, and 17.8% in 1972, 1982, and 1987, respectively, as determined by dot-blot hybridization. However, the PCR detected HPV 16 in an additional 55.5%, 62.9%, and 57.0% of cytologically normal and dot-blot negative smears. The prevalence of HPV 16 infection in cytologically normal smears was estimated to be 71.0%, 74.1%, and 74.8% in 1972, 1982, and 1987, respectively, by combining the HPV 16 dot-blot and PCR-positive results. The high prevalence of HPV 16 in cytologically normal Pap smears suggests that infection with HPV 16, as detected by PCR amplification, does not place women in a high-risk category for cervical cancer.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Time trends in the prevalence of human papillomavirus infections in archival Papanicolaou smears: Analysis by cytology, DNA hybridization, and polymerase chain reaction

Rakoczy¹,

Sterrett²,

Kulski³

et al. 1990

Journal of Medical Virology

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“…Currently, comparisons between studies on trends in serological hr-HPV prevalence over time are limited because most studies are focused on DNA prevalence or incidence of cervical intraepithelial neoplasia (CIN) in women [14] , [15] , [16] , [17] . We have examined changes in antibody seroprevalence between 1995–96 and 2006–07 surveys in men and women in The Netherlands for HPV serotypes 16, 18, 31, 33, 45, 52, and 58.…”

Section: Introductionmentioning

confidence: 99%

Changes in Antibody Seroprevalence of Seven High-Risk HPV Types between Nationwide Surveillance Studies from 1995–96 and 2006–07 in The Netherlands

et al. 2012

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ObjectiveThis study evaluates trends in antibody seroprevalences of seven high-risk human papillomavirus (hr-HPV) serotypes (HPV16, 18, 31, 33, 45, 52, and 58) between the 1995–96 and 2006–07 sero-surveys among the Dutch general population in the pre-vaccination era.MethodsSerum samples of men and women (0–79 years of age) from two cross-sectional population-based serosurveillance studies performed in 1995–96 (n = 3303) and 2006–07 (n = 6384) were tested for HPV-specific antibodies in a VLP-based multiplex immunoassay.ResultsHPV16-specific antibody seroprevalence increased during adolescence and shifted to younger ages in the 2006–07 survey compared to the 1995–96 survey. This step-up in HPV16 seroprevalence was most pronounced in women, while a more gradual increase was observed in men. Also in cohorts older than 49 years, HPV16 seroprevalence was higher in 2006–07 as compared to 1995–96 survey. A higher overall seroprevalence in individuals older than 15 years of age was found for HPV16, 18, 31 and 45 in 2006–07 as compared to 1995–96. For HPV33, 52 and 58 seroprevalences were comparable over this 11-year time period. Seropositivity for one or more HPV types was significantly higher in 2006–07 (23.1%) than in 1995–96 (20.0%) (p = 0.013). Multi-seropositivity increased from 7.1% in 1995–96 up to 10.2% in 2006–07 (p<0.0001). Differences in HPV seropositivity for at least one of the seven HPV types between both surveys could be explained in addition to demographic characteristics (age, sex, urbanization degree and ethnicity), also by changes in sexual behaviour (marital status, age of sexual debut and ever reported an STI).ConclusionThe observed increase in particular HPV16 seroprevalence could be due to changes in sexual behaviour over the years, and especially in age of sexual debut. Seroprevalence studies provide insight into the distribution of HPV types and infection dynamics in the general population over time, which is important to assess the impact of HPV-vaccination.

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“…In subsequent reports in various parts of the Western world estimates have ranged from 0.9 to 6%94. Armstrong et al 97 investigated women attending an STD clinic in Western Australia between 1978 and 1982. The prevalence of cytologically detectable cervical HPV infection increased from 2.8% to 9.3%; however, further analysis revealed that this apparent increase was due to an improved recognition of the cytological hallmarks of HPV infection.…”

Section: Increase Of Gpvi During Recent Decades?mentioning

confidence: 99%

Genitoanal Papillomavirus Infection: Diagnostic and Therapeutic Objectives in the Light of Current Epidemiological Observations

1991

Int J STD AIDS

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Summary: During the past decade a wide span of heterogeneity has been demonstrated for human papillomaviruses (HPVs), and some basic properties of the HPV genome have been revealed. The use of hybridization assays for HPV DNA detection in infected epithelia, and the recent introduction of synthetic HPV peptides for detection of type-specific circulating antibodies, have resulted in a major rethinking of HPV epidemiology. Recent data indicate that various HPVs may be transmitted perinatally during early infancy and that a long latency with periodic reactivation seems to be quite common. The present review attempts to assess recent epidemiological data with the concept of genitoanal papillomavirus infection (GPVI) as a predominantly sexually transmitted disease. Some diagnostic and therapeutic aspects are outlined with a pragmatic approach to the clinical relevance of GPVI.

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Time trends in prevalence of cervical cytological abnormality in women attending a sexually transmitted diseases clinic and their relationship to trends in sexual activity and specific infections

Cited by 19 publications

References 8 publications

Time trends in the prevalence of human papillomavirus infections in archival Papanicolaou smears: Analysis by cytology, DNA hybridization, and polymerase chain reaction

Time trends in the prevalence of human papillomavirus infections in archival Papanicolaou smears: Analysis by cytology, DNA hybridization, and polymerase chain reaction

Changes in Antibody Seroprevalence of Seven High-Risk HPV Types between Nationwide Surveillance Studies from 1995–96 and 2006–07 in The Netherlands

Genitoanal Papillomavirus Infection: Diagnostic and Therapeutic Objectives in the Light of Current Epidemiological Observations

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