Time trends in peptic ulcer, erosive reflux oesophagitis, gastric and oesophageal cancers in a multiracial Asian population

Goh, Khean‐Lee; Wong, Hui Tong; Lim, C.‐H.; Rosaida, M. S.

doi:10.1111/j.1365-2036.2009.03930.x

Cited by 25 publications

(32 citation statements)

References 24 publications

(55 reference statements)

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“…In the first period of the present study, we noted that the rate of GU was almost 2-fold higher compared with DU-consistent with the results of previous studies in Japan (30,31). However, this changed over the 25-year period as the dominance of GU over DU decreased, with the prevalence of GU and DU becoming comparable in recent times, consistent with the report of Goh et al (32). A possible explanation for this change is the decreased prevalence of H. pylori infection.…”

Section: Discussionsupporting

confidence: 93%

Changes of Upper Gastrointestinal Symptoms and Endoscopic Findings in Japan Over 25 Years

et al. 2011

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Background and Aims In Japan, the prevalence of Helicobacter pylori infection has decreased recently, but there has been little longitudinal research on the changes of symptoms and endoscopic findings over many years. The aim of this study was to evaluate the changes in endoscopic findings and symptoms over time in patients undergoing upper gastrointestinal endoscopy for assessment of upper abdominal symptoms. Methods Over a period of 25 years, between 1981 and 2005, we performed three investigations (1981-2, 1990-1 and 2004-5) on the symptoms and endoscopic findings of patients undergoing endoscopy at Kawasaki Medical School Hospital for the assessment of upper abdominal symptoms. Results The most common complaint for all ages was "discomfort and/or pain". Over time, the percentage of patients complaining of "heartburn" increased almost 5-fold. With respect to endoscopic findings, the prevalence of peptic ulcers decreased, whereas the detection of no abnormalities and the detection of erosive esophagitis increased. Conclusion In the future in Japan, there will be fewer patients with peptic ulcers and more patients with gastro-esophageal reflux disease or dyspeptic patients who display no endoscopic abnormal findings.

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Section: Discussionsupporting

confidence: 93%

Changes of Upper Gastrointestinal Symptoms and Endoscopic Findings in Japan Over 25 Years

et al. 2011

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“…In the western countries, hospitalization and mortality rates for peptic ulcer and gastric cancer had dropped substantially from 1970 and 1995, while hospitalisation rates for GERD and esophageal adenocarcinoma rose significantly [15]. In Asia, similar rising trend of symptomatic GERD, endoscopic esophagitis and even esophageal adenocarcinoma has been observed in many retrospective endoscopy-based studies, and these changes in prevalence were coincident with a decline in prevalence of H. pylori infection, peptic ulcer and gastric cancers [16][17][18][19][20].…”

Section: Opposing Secular Trends Of H Pylori Related Diseases and Gerdmentioning

confidence: 81%

Does Helicobacter pylori infection protect against esophageal diseases in Asia?

2011

Indian J Gastroenterol

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The speculations on the protective role of Helicobacter pylori against gastroesophageal reflux disease (GERD) originated from epidemiological observations. These studies have shown that the rising trend of GERD is coincident with declining prevalence of H. pylori and peptic ulcer disease in Asia. Furthermore, most case-control and population-based studies suggest a negative association between H. pylori infection and GERD. It is generally believed that the preponderance of cagA+ and vacA+ virulent strains and proinflammatory interleukin-1 beta polymorphism increase the risk of hypochlohydria and protects against the development of GERD in Asian population. Recovery of gastric acid secretion and emergence of reflux esophagitis has been reported after H. pylori eradication in patients with corpus gastritis and atrophic gastritis. Recent studies have also reported that H. pylori eradication leads to recovery of ghrelin secreting cells in the gastric corpus and a rise in plasma ghrelin levels, which may contribute to obesity through its appetite-stimulating action and predispose to GERD. The prevalence of H. pylori infection is generally lower in younger Asians who enjoy improved socioeconomic status and sanitation compared with their older counterparts. The Asian population is probably facing a rising generation with high gastric acid and ghrelin secretion rates. These physiological changes may contribute to increased dietary calorie intake, obesity and increased prevalence of GERD.

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“…During the last few decades, a change has been observed in the incidence of many gastrointestinal diseases, such as gastric cancer, acid-peptic disease including peptic ulcer, and gastroesophageal reflux disease [1]. Gastroesophageal reflux disease (GERD) was previously thought to be a rare disease in the East, but several recent reviews have also brought up the possibility of an increase in the prevalence of GERD.…”

Section: Introductionmentioning

confidence: 99%

The Changing Pattern of Upper Gastrointestinal Disorders by Endoscopy: Data of the Last 40 Years

Çağlar

Baysal

Dobrucalı

2014

Diagnostic and Therapeutic Endoscopy

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Objectives. We have investigated the changes in the incidence of various diagnoses that have been made in the endoscopy unit throughout the last 40 years. Methods. In this study, changes in the incidence of endoscopic diagnosis in upper gastrointestinal system between 1970 and 2010 were evaluated. Their diagnosis, age, and gender data were entered into the Excel software. Results. Of the 52816 cases who underwent esophagogastroduodenoscopy in the 40-year time period, the mean age was 48.17 ± 16.27 (mean ± SD). Although overall more than half of the patients were male (54.3%), in 1995 and after a marked increase was seen in the proportion of female gender (51–55%). The presence of hiatal hernia, reflux esophagitis, and the number of Barrett's esophaguses significantly increased. Erosive gastritis showed gradual increase, while the number of gastric ulcers decreased significantly. The presence of gastric and esophageal cancer significantly decreased. The number of duodenal ulcers significantly decreased. Conclusion. We detected that the incidences of esophagitis, Barrett's esophagus, and erosive gastritis significantly increased while the incidences of gastric/duodenal ulcer and gastric/esophageal cancer decreased throughout the last 40 years.

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Time trends in peptic ulcer, erosive reflux oesophagitis, gastric and oesophageal cancers in a multiracial Asian population

Abstract: SUMMARY BackgroundDramatic changes in the prevalence and pattern of gastrointestinal disease has taken place in Asia in recent years.

Cited by 25 publications

References 24 publications

Changes of Upper Gastrointestinal Symptoms and Endoscopic Findings in Japan Over 25 Years

Changes of Upper Gastrointestinal Symptoms and Endoscopic Findings in Japan Over 25 Years

Does Helicobacter pylori infection protect against esophageal diseases in Asia?

The Changing Pattern of Upper Gastrointestinal Disorders by Endoscopy: Data of the Last 40 Years

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