Time trend in tumour size and characteristics of anaplastic thyroid carcinoma

Han, Ji Min; Kim, Won; Kim, Tae Yong; Ryu, Jin‐Sook; Gong, Gyungyub; Hong, Suck Joon; Kim, Jung-Han; Oh, Young Lyun; Jang, Hye Won; Kim, Sun Wook; Chung, Jae Hoon; Shong, Young Kee

doi:10.1111/j.1365-2265.2012.04396.x

Cited by 30 publications

(28 citation statements)

References 17 publications

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“…Anaplastic TC is a highly aggressive malignancy [28], whereas K1 papillary TC is well differentiated and has a good prognosis [29]. Squamous TC is an aggressive neoplasm which has a bad prognosis [30].…”

Section: Discussionmentioning

confidence: 99%

Overexpression of long intergenic noncoding RNA LINC00312 inhibits the invasion and migration of thyroid cancer cells by down-regulating microRNA-197-3p

Huang

Yan

et al. 2017

Bioscience Reports

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The study evaluated the ability of long intergenic noncoding RNA LINC00312 (LINC00312) to influence the proliferation, invasion, and migration of thyroid cancer (TC) cells by regulating miRNA-197-3p. TC tissues and adjacent normal tissues were collected from 211 TC patients. K1 (papillary TC), SW579 (squamous TC), and 8505C (anaplastic TC) cell lines were assigned into a blank, negative control (NC), LINC00312 overexpression, miR-197-3p inhibitors, and LINC00312 overexpression + miR-197-3p mimics group. The expression of LINC00312, miR-197-3p, and p120 were measured using quantitative real-time PCR (qRT-PCR) and Western blotting. Cell proliferation was assessed via CCK8 assay, cell invasion through the scratch test, and cell migration via Transwell assay. In comparison with adjacent normal tissues, the expression of LINC00312 is down-regulated and the expression of miR-197-3p is up-regulated in TC tissues. The dual luciferase reporter gene assay confirmed that P120 is a target of miR-197-3p. The expression of LINC00312 and p120 was higher in the LINC00312 overexpression group than in the blank and NV groups. However, the expression of miR-197-3p was lower in the LINC00312 overexpression group than in the blank and NC groups. The miR-197-3p inhibitors group had a higher expression of miR-197-3p, but a lower expression of p120 than the blank and NC groups. The LINC00312 overexpression and miR-197-3p inhibitor groups had reduced cell proliferation, invasion and migration than the blank and NC groups. These results indicate that a LINC00312 overexpression inhibits the proliferation, invasion, and migration of TC cells and that this can be achieved by down-regulating miR-197-3p.

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Section: Discussionmentioning

confidence: 99%

Overexpression of long intergenic noncoding RNA LINC00312 inhibits the invasion and migration of thyroid cancer cells by down-regulating microRNA-197-3p

Huang

Yan

et al. 2017

Bioscience Reports

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“…In fact, recent studies have demonstrated longer survival rates compared to the past [4,24] and additionally evidence exists, obtained by in vitro experiments, of the effectiveness of certain drugs which exert on the one hand a cytoreductive effect on anaplastic clones, and on the other hand which favors redifferentiation, inducing the reacquisition of the ability to uptake 131 I [30e34]: this may render the clones susceptible to radiometabolic therapy with 131 I. In addition, the loss of anaplasia, may also render them less resistant to external radiotherapy.…”

Section: Discussionmentioning

confidence: 95%

“…Anaplastic carcinomas and those which are poorly differentiated are neoplasms strictly found in advanced age, and are very rare in patients under 60 years of age [1e3]. They are very aggressive cancers with a high mortality rate [4].Well-differentiated carcinomas, on the other hand, are much more frequent compared to undifferentiated forms and have a good prognosis with low mortality rates and a survival rate which varies between 80% and 95% [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

Cancer of the thyroid gland in geriatric age: A single center retrospective study with a 10-year post-operative follow-up

Santangelo

Giudice

Gallucci

et al. 2014

International Journal of Surgery

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“…Recently, the wide use of high resolution US has provided early detection of thyroid malignancy, and this might contribute to an earlier detection of ATC. Han, et al38 reported time trends of tumor size and characteristics of ATC. They reported that the mean tumor size of ATC decreased significantly and the frequencies of coexistent differentiated thyroid cancer (DTC) increased over time.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Thyroid Cancer: Ultrasonographic Findings and the Role of Ultrasonography-Guided Fine Needle Aspiration Biopsy

et al. 2013

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PurposeTo investigate the ultrasonographic (US) features of anaplastic thyroid cancer (ATC) and the diagnostic performance of US-guided fine needle aspiration biopsy (FNAB) therein.Materials and MethodsEighteen cases of ATC diagnosed between January 2001 and May 2011 were included. FNAB was performed in all cases. Initial FNAB results were divided into three groups: 1) the cytological ATC group, cytological diagnosis of ATC; 2) the underestimated group, cytological diagnoses of malignancy other than ATC; and 3) the false negative group, cytological diagnoses of atypical, benign and non-diagnostic lesions. We retrospectively reviewed US findings and compared treatment modalities between each group.ResultsAmong the 18 patients, there were nine in the initially cytological ATC group, four in the underestimated group and five in the false negative group. The most common US features of ATC were a solid (64.7%) and irregular shaped (88.2%) mass with lymph node involvement (76.4%). However, except for lymph node involvement (p=0.003), US findings for each group were not statistically different. The initial cytological diagnostic accuracy of ATC was 50% (9/18). Surgery was performed less in the ATC group (11%) and the false negative group (20%) than the underestimated group (75%).ConclusionThe US features of ATC were not especially different from other types of aggressive thyroid cancer. A correct diagnosis of ATC by initial US-FNAB was made in 50% of the patients, which is significant in that therapeutic surgery can be undertaken in lower numbers if correctly diagnosed.

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Time trend in tumour size and characteristics of anaplastic thyroid carcinoma

Cited by 30 publications

References 17 publications

Overexpression of long intergenic noncoding RNA LINC00312 inhibits the invasion and migration of thyroid cancer cells by down-regulating microRNA-197-3p

Overexpression of long intergenic noncoding RNA LINC00312 inhibits the invasion and migration of thyroid cancer cells by down-regulating microRNA-197-3p

Cancer of the thyroid gland in geriatric age: A single center retrospective study with a 10-year post-operative follow-up

Anaplastic Thyroid Cancer: Ultrasonographic Findings and the Role of Ultrasonography-Guided Fine Needle Aspiration Biopsy

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