Time trend in frequency of occurrence of major immunophenotypes in paediatric acute lymphoblastic leukemia cases as experienced by Cancer Institute, Chennai, south India during the period 1989-2009

Rajalekshmy, K. R.; Abitha, AR; Anuratha, N; Sagar, TG

doi:10.4103/0019-509x.84932

Cited by 13 publications

(9 citation statements)

References 22 publications

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“…Western data clearly shows a higher incidence of B-ALL over T-ALL. However many older studies done among Asian, African and middle eastern populations have shown a higher incidence of T-ALL [5][6][7]. Our data also show a higher incidence in the B-ALL category with frequencies similar to that reported in the Americas and Europe.…”

Section: Immunophenotypesupporting

confidence: 87%

“…However there is evidence to state that the geographic difference in incidence is more likely due to the socioeconomic status of the population than ethnicity. This was highlighted by two independent studies carried out in south and north India, that showed the change in trends from T-All to B-ALL with the changing socioeconomic status of a single concerned population [5,6]. Similar changes have been observed in other developing nations [4].…”

Section: Immunophenotypementioning

confidence: 74%

“…B-ALL was more frequent than T-ALL independent of the age group analyzed. The geographic variation of ALL is well established [1,4,5]. This difference has been linked to ethnicity and socioeconomic status.…”

Section: Immunophenotypementioning

confidence: 99%

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Immunophenotypic characterization of acute lymphoblastic leukemia in a flowcytometry reference centre in Sri Lanka

et al. 2020

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Background Acute lymphoblastic leukemia (ALL), is a biologically heterogeneous disease where diagnosis, treatment and prognosis is heavily dependent on the correct characterization of the immunophenotype of each case. Objectives To describe the immunophenotypic and laboratory features of a cohort of Sri Lankan children and adults with ALL and to compare them with those reported in other series. Methods Records of 229 patients who were suspected of having acute leukaemia and referred for flow cytometry to the Asiri Hospital Sri Lanka, between August 2009 and October 2013 were reviewed. Referrals were from across the country including the National Cancer Institute. Results Sixty seven percent were children below 12 years of age. 80% had B-lymphoblastic leukaemia (B-ALL), 20% T-lymphoblastic leukaemia (T-ALL). In children, the peak age of diagnosis was between 2-6 years in BALL (61%) and 3-6 years (43.7%) in TALL. Incidence was commoner in males in all age groups and subtypes except in the adult B ALL group where the incidence was equal. Ninety three percent of paediatric BALL and 67% adult BALL were CD10 positive common ALL. In TALL cytoplasmic expression of CD3 was 100%. nTdT was the most commonly expressed immature marker, in BALL -91% and in TALL -69%. At least one myeloid antigen was present in 34% of BALL cases and 60% of TALL cases. Conclusions This study represents the first immunophenotype based description of ALL in Sri Lanka. Age, sex distribution, ALL subtypes and the immunophenotypic profile of each subtype mirrored those of previous studies.

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Section: Immunophenotypesupporting

confidence: 87%

Section: Immunophenotypementioning

confidence: 74%

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Immunophenotypic characterization of acute lymphoblastic leukemia in a flowcytometry reference centre in Sri Lanka

et al. 2020

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“…[6] In India also, studies reported from Tata Memorial Hospital, Mumbai, All India Institute of Medical Sciences, New Delhi and Cancer Institute, Chennai revealed a declining trend of T-ALL accompanied by an increasing trend in B-ALL among children. [789] Thus most of these studies have focused predominantly on B-ALL. Moreover, in the existing scenario, specific outcome data for adolescents was relatively sparse.…”

Section: Discussionmentioning

confidence: 99%

Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India

Mukhopadhyay

Gangopadhyay

Dasgupta

et al. 2013

Indian Journal of Medical and Paediatric Oncology

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Objective:Research in Eastern India especially among children and adolescents for acute lymphoblastic leukemia (ALL) have not been well documented until recently when it was conducted at a cancer institute of tertiary care with primary objectives of examining and correlating different cell surface markers involved with respect to disease surveillance thereby highlighting it as a strong prognostic marker for future diagnosis and treatment.Materials and Methods:A total of 500 consecutively selected ALL patients were diagnosed and treated according to National Cancer Institute protocol (MCP 841) for a period of 24-88 months during this hospital-based study.Results:Of the total, 50.4% had a higher incidence of T-ALL and 47.6% had pro-B, B-cell precursor ALL. Disease free survival and event free survival were remarkably higher in B-ALL adolescent patients as compared to T-ALL, who had significantly lower overall survival ratio. Prevalence of T-ALL was also observed in relapse cases for adolescent patients.Conclusions:We conclude that there is an increased prevalence of T-ALL among adolescents in Eastern India. Immunophenotypic analysis might help in proper evaluation and prediction of treatment outcomes with an increased thrust on studying age-specific incident rates enabling well planned future treatments for improved and better outcome.

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“…Although this provides an excellent opportunity for evaluating unique contributions of prognostic factors within each immunophenotype group, direct comparison of outcome between T and B lineage becomes difficult because of the different treatment regimen used. Furthermore, there is paucity of data addressing clinical features, prognostic parameters and outcome of T ALL in developing countries like India, where this ALL subtype is more frequently observed than in the developed nations (16,17) . Disease free survival and event free survival were higher in B ALL in adolescent patients as compared to T ALL who had significantly low survival rates (18) .…”

Section: Discussionmentioning

confidence: 99%

CD34 Positive Pediatric T Lymphoblastic Leukemia: A Tertiary Care Centre Experience

.P¹

2017

JMSCR

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Time trend in frequency of occurrence of major immunophenotypes in paediatric acute lymphoblastic leukemia cases as experienced by Cancer Institute, Chennai, south India during the period 1989-2009

Cited by 13 publications

References 22 publications

Immunophenotypic characterization of acute lymphoblastic leukemia in a flowcytometry reference centre in Sri Lanka

Immunophenotypic characterization of acute lymphoblastic leukemia in a flowcytometry reference centre in Sri Lanka

Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India

CD34 Positive Pediatric T Lymphoblastic Leukemia: A Tertiary Care Centre Experience

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