Time to set the agenda for schistosomiasis elimination

Rollinson, David; Knopp, Stefanie; Levitz, Sarah; Stothard, J. Russell; Tchuenté, Louis-Albert Tchuem; Garba, Amadou; Mohammed, Khalfan A.; Schur, Nadine; Person, Bobbie; Colley, Daniel G.; Utzinger, Jürg

doi:10.1016/j.actatropica.2012.04.013

Cited by 519 publications

(506 citation statements)

References 120 publications

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“…What's more, bold objectives have been set for the elimination and eradication of malaria and a host of neglected tropical diseases (Alonso et al, 2011;WHO, 2012;Rollinson et al, 2013). Hence, there is a need to continue and intensify research and development for new and improved tools and strategies (e.g.…”

Section: Introductionmentioning

confidence: 99%

Geospatial (s)tools: integration of advanced epidemiological sampling and novel diagnostics

Cringoli

Rinaldi

Albonico³

et al. 2013

Geospat Health

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Abstract. Large-scale control and progressive elimination of a wide variety of parasitic diseases is moving to the fore. Indeed, there is good pace and broad political commitment. Yet, there are some worrying signs ahead, particularly the anticipated declines in funding and coverage of key interventions, and the paucity of novel tools and strategies. Further and intensified research and development is thus urgently required. We discuss advances in epidemiological sampling, diagnostic tools and geospatial methodologies. We emphasise the need for integrating sound epidemiological designs (e.g. cluster-randomised sampling) with innovative diagnostic tools and strategies (e.g. Mini-FLOTAC for detection of parasitic elements and pooling of biological samples) and high-resolution geospatial tools. Recognising these challenges, standardisation of quality procedures, and innovating, validating and applying new tools and strategies will foster and sustain long-term control and eventual elimination of human and veterinary public health issues.

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Section: Introductionmentioning

confidence: 99%

Geospatial (s)tools: integration of advanced epidemiological sampling and novel diagnostics

Cringoli

Rinaldi

Albonico³

et al. 2013

Geospat Health

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“…However, preventive chemotherapy does not prevent people from rapid reinfection with parasitic worms [2,3]. In view of the current discussion and efforts to shift from morbidity control to interruption of transmission of neglected tropical diseases, ongoing efforts need to be intensified, along with concurrent implementation of complementary interventions [4][5][6][7]. Indeed, integrated approaches, combining preventive chemotherapy with water, sanitation and hygiene (WASH), and information, education and communication (IEC) are necessary to sustain the gains made in the control of helminthiases and eventually break transmission [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

An Integrated Approach to Control Soil-Transmitted Helminthiasis, Schistosomiasis, Intestinal Protozoa Infection, and Diarrhea: Protocol for a Cluster Randomized Trial (Preprint)

Raso¹,

Essé²,

Dongo³

et al. 2017

Preprint

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BACKGROUND The global strategy to control helminthiases (schistosomiasis and soil-transmitted helminthiasis) emphasizes preventive chemotherapy. However, in the absence of access to clean water, improved sanitation, and adequate hygiene, reinfection after treatment can occur rapidly. Integrated approaches might be necessary to sustain the benefits of preventive chemotherapy and make progress toward interruption of helminthiases transmission. OBJECTIVE The aim of this study was to assess and quantify the effect of an integrated control package that consists of preventive chemotherapy, community-led total sanitation, and health education on soil-transmitted helminthiasis, schistosomiasis, intestinal protozoa infection, and diarrhea in rural Côte d’Ivoire. METHODS In a first step, a community health education program was developed that includes an animated cartoon to promote improved hygiene and health targeting school-aged children, coupled with a health education theater for the entire community. In a second step, a cluster randomized trial was implemented in 56 communities of south-central Côte d’Ivoire with 4 intervention arms: (1) preventive chemotherapy; (2) preventive chemotherapy plus community-led total sanitation; (3) preventive chemotherapy plus health education; and (4) all 3 interventions combined. Before implementation of the aforementioned interventions, a baseline parasitologic, anthropometric, and hygiene-related knowledge, attitudes, practices, and beliefs survey was conducted. These surveys were repeated 18 and 39 months after the baseline cross-sectional survey to determine the effect of different interventions on helminth and intestinal protozoa infection, nutritional indicators, and knowledge, attitudes, practices, and beliefs. Monitoring of diarrhea was done over a 24-month period at 2-week intervals, starting right after the baseline survey. RESULTS Key results from this cluster randomized trial will shed light on the effect of integrated approaches consisting of preventive chemotherapy, community-led total sanitation, and health education against infections with soil-transmitted helminths, schistosomes, an intestinal protozoa and prevention of diarrhea in a rural part of Côte d’Ivoire. CONCLUSIONS The research provided new insights into the acceptability, strengths, and limitations of an integrated community-based control package targeting helminthiases, intestinal protozoa infections, and diarrhea in rural communities of Côte d’Ivoire. In the longer term, the study will allow determining the effect of the integrated control approach on infection patterns with parasitic worms and intestinal protozoa, diarrheal incidence, anthropometric measures, and hygiene-related knowledge, attitudes, practices, and beliefs. CLINICALTRIAL International Standard Randomized Controlled Trial Number (ISRCTN): 53102033; http://www.isrctn.com/ISRCTN53102033 (Archived by WebCite at http://www.webcitation.org/6wpnXEiHo) REGISTERED REPORT IDENTIFIER RR1-10.2196/9166

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“…In fact, since PZQ was marketed in 1984, no new drug has entered the market to fight this disease, [20] while the number of chemotherapeutic treatments against this disease gradually increased from 12.4 million people in 2006 to over 42.1 million people treated in 2012. [21,22] It is anticipated that this number will further increase in the future. [21,22] These distressing facts were the reasons for the start of our program on the evaluation of novel organometallic complexes as novel antischistosomal drug candidates.…”

Section: Introductionmentioning

confidence: 99%

“…[21,22] It is anticipated that this number will further increase in the future. [21,22] These distressing facts were the reasons for the start of our program on the evaluation of novel organometallic complexes as novel antischistosomal drug candidates. [11] The concept that we have decided to employ to provide new lead structures in As As As As organometallic compounds to fight schistosomiasis.…”

Section: Introductionmentioning

confidence: 99%