Time to revise the paradigm of hantavirus syndromes? Hantavirus pulmonary syndrome caused by European hantavirus

Rasmuson, Johan; Andersson, Christian; Norrman, Eva; Haney, Michael; Evander, Magnus; Ahlm, Clas

doi:10.1007/s10096-010-1141-6

Cited by 105 publications

(104 citation statements)

References 21 publications

(33 reference statements)

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“…However, evidence is now mounting for clinical and pathological overlap between HPS and HFRS [28,29]. Consequently, hantavirus infections should be considered a cause of acute respiratory distress in all endemic areas worldwide [28]. Indeed, Quelapio et al [27] provided substantial evidence that hantavirus infection does occur in the Philippines.…”

Section: Discussionmentioning

confidence: 99%

Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines

Sumi

Telan²,

Chagan-Yasutan

et al. 2016

Epidemiol. Infect.

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SUMMARYDengue fever (DF) and leptospirosis are serious public problems in tropical regions, especially in Manila, the Philippines. In attempting to understand the causes of DF and leptospirosis seasonality, meteorological factors have been suspected, but quantitative correlation between seasonality and meteorological factors has not been fully investigated. In this study, we investigated correlation of temporal patterns of reported numbers of laboratory-confirmed cases of both DF and leptospirosis with meteorological conditions (temperature, relative humidity, rainfall) in Manila. We used time-series analysis combined with spectral analysis and the least squares method. A 1-year cycle explained underlying variations of DF, leptospirosis and meteorological data. There was a peak of the 1-year cycle in temperature during May, followed by maxima in rainfall, relative humidity and number of laboratory-confirmed DF and leptospirosis cases. This result suggests that DF and leptospirosis epidemics are correlated not only with rainfall but also relative humidity and temperature in the Philippines. Quantifying the correlation of DF and leptospirosis infections with meteorological conditions may prove useful in predicting DF and leptospirosis epidemics, and health services should plan accordingly.

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Section: Discussionmentioning

confidence: 99%

Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines

Sumi

Telan²,

Chagan-Yasutan

et al. 2016

Epidemiol. Infect.

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“…An infection with Old World hantaviruses often leads to acute renal failure with massive proteinuria (1,51,71). In recent years reports of cases with pulmonary involvement in Old World hantavirus infection were reported, as well as involvement of other organs (28,58). The understanding of the susceptibility of human cells for hantavirus infection and the effects of replication on the host cell is crucial for the study of the underlying mechanism of hantaviral pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…The target organ that is mainly affected in its function by the infection with a pathogenic Old World hantavirus is the kidney, leading to the hemorrhagic fever with renal syndrome (HFRS) (14,42,46,85). Pulmonary findings in Old World hantavirus and renal involvement in New World hantavirus infection may be observed as well (44,58,86). Furthermore, both viruses can affect several other organs (28,39).…”

mentioning

confidence: 99%

Pathogenic Old World Hantaviruses Infect Renal Glomerular and Tubular Cells and Induce Disassembling of Cell-to-Cell Contacts

Krautkrämer

Grouls

Stein

et al. 2011

J Virol

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Viral hemorrhagic fevers are characterized by enhanced permeability. One of the most affected target organs of hantavirus-induced hemorrhagic fever with renal syndrome is the kidney, and an infection often results in acute renal failure. To study the underlying cellular effects leading to kidney dysfunction, we infected human renal cell types in vitro that are critical for the barrier functions of the kidney, and we examined kidney biopsy specimens obtained from hantavirus-infected patients. We analyzed the infection and pathogenic effects in tubular epithelial and glomerular endothelial renal cells and in podocytes. Both epithelial and endothelial cells and podocytes were susceptible to hantavirus infection in vitro. The infection disturbed the structure and integrity of cell-to-cell contacts, as demonstrated by redistribution and reduction of the tight junction protein ZO-1 and the decrease in the transepithelial resistance in infected epithelial monolayers. An analysis of renal biopsy specimens from hantavirus-infected patients revealed that the expression and the localization of the tight junction protein ZO-1 were altered compared to renal biopsy specimens from noninfected individuals. Both tubular and glomerular cells were affected by the infection. Furthermore, the decrease in glomerular ZO-1 correlates with disease severity induced by glomerular dysfunction. The finding that different renal cell types are susceptible to hantaviral infection and the fact that infection results in the breakdown of cell-to-cell contacts provide useful insights in hantaviral pathogenesis.

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“…Hantavirus pulmonary syndrome (HPS) occurs in the Americas (4) (5) , while hemorrhagic fever with renal syndrome (HFRS) occurs in Europe and Asia (2) (3) (6) , with occasional reports of cross occurrence (7) .…”

Section: Introductionmentioning

confidence: 99%

Ten years of a hantavirus disease emergency in the Federal District, Brazil

Dusi

Bredt

Freitas

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction: Hantavirus diseases are emerging human diseases caused by Hantavirus spp. of the Bunnyaviridae family. Hantavirus pulmonary syndrome (HPS) has been detected in the Federal District (DF) of Brazil since 2004. Among the 27 Brazilian Federal Units, DF has the highest fatality rate. More than 10 years have already passed since then, with confi rmation of cases caused by the Araraquara and Paranoa species. The reservoir is Necromys lasiurus. Methods: Local surveillance data of the confi rmed cases were analyzed, including age, sex, month and year of occurrence, clinical symptoms, syndromes and outcomes, and probable transmission place (PTP). The cases were mainly confi rmed by IgM detection with a capture enzyme immunoassay. The cases were classifi ed as autochthonous if PTPs were in the DF area. Results: From 2004 to 2013, in the DF, 126 cases of hantavirus were confi rmed, and the cumulative incidence was 5.0 per 100,000 inhabitants. The occurrence of cases was predominantly from April to August. At least 75% of the cases were autochthonous. Acute respiratory failure was reported in 47.5% of cases, and the fatality rate was 40%. Conclusions: In the DF, the cumulative incidence of HPS was one of the highest worldwide. A seasonal pattern of hantavirus disease in the dry season is clear. There was a high frequency of severe clinical signals and symptoms as well as a high fatality rate. For the near future, visitors and inhabitants of DF rural areas, particularly male adults, should receive continuous education about hantavirus transmission and prevention.

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Time to revise the paradigm of hantavirus syndromes? Hantavirus pulmonary syndrome caused by European hantavirus

Cited by 105 publications

References 21 publications

Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines

Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines

Pathogenic Old World Hantaviruses Infect Renal Glomerular and Tubular Cells and Induce Disassembling of Cell-to-Cell Contacts

Ten years of a hantavirus disease emergency in the Federal District, Brazil

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