Time to pregnancy as a function of male and female serum concentrations of 2,2′4,4′5,5′-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p′-DDE)

Axmon, Anna; Thulstrup, A. M.; Rignell-Hydbom, Anna; Pedersen, Henning Sloth; Zvyezday, Valentyna; Ludwicki, Jan K; Jönsson, Bo; Toft, Gunnar; Bonde, JP; Hagmar, Lars

doi:10.1093/humrep/dei397

Cited by 52 publications

(40 citation statements)

References 48 publications

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“…The question whether malarial fever could explain the results has unfortunately not been addressed. The environmental exposure levels in these studies are high compared to current levels of DDT and DDT-metabolites in populations of other parts of the world, where low-level DDT exposure has not been associated with reduced sperm counts or male infertility [45,46]. In any case it is , disturbing that low-level exposure to PCBcongeners apparently interferes with sperm cell motility and sperm chromatin integrity in humans--findings that are consistent with experimental studies [47].…”

Section: Occupational Hazardssupporting

confidence: 67%

Male reproductive organs are at risk from environmental hazards

Bonde¹

2009

Asian J Androl

106

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Male reproductive disorders that are of interest from an environmental point of view include sexual dysfunction, infertility, cryptorchidism, hypospadias and testicular cancer. Several reports suggest declining sperm counts and increase of these reproductive disorders in some areas during some time periods past 50 years. Except for testicular cancer this evidence is circumstantial and needs cautious interpretation. However, the male germ line is one of the most sensitive tissues to the damaging effects of ionizing radiation, radiant heat and a number of known toxicants. So far occupational hazards are the best documented risk factors for impaired male reproductive function and include physical exposures (radiant heat, ionizing radiation, high frequency electromagnetic radiation), chemical exposures (some solvents as carbon disulfide and ethylene glycol ethers, some pesticides as dibromochloropropane, ethylendibromide and DDT/DDE, some heavy metals as inorganic lead and mercury) and work processes such as metal welding. Improved working conditions in affluent countries have dramatically decreased known hazardous workplace exposures, but millions of workers in less affluent countries are at risk from reproductive toxicants. New data show that environmental low-level exposure to biopersistent pollutants in the diet may pose a risk to people in all parts of the world. For other toxicants the evidence is only suggestive and further evaluation is needed before conclusions can be drawn. Whether compounds as phthalates, bisphenol A and boron that are present in a large number of industrial and consumer products entails a risk remains to be established. The same applies to psychosocial stressors and use of mobile phones. Finally, there are data indicating a particular vulnerability of the fetal testis to toxicants-for instance maternal tobacco smoking. Time has come where male reproductive toxicity should be addressed form entirely new angles including exposures very early in life.

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Section: Occupational Hazardssupporting

confidence: 67%

Male reproductive organs are at risk from environmental hazards

Bonde¹

2009

Asian J Androl

106

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“…The observed reduction in litter size is a likely consequence of poor rearing because unpublished data from our laboratory revealed no differences in fetal number at embryonic day 18 when dams were administered 1 μmole/kg 7 PCB 126 similar to the current exposure model (data not shown). Studies in humans have shown conflicting effects of maternal PCB exposure on fecundity, and specifically time to pregnancy [31][32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Perinatal polychlorinated biphenyl 126 exposure alters offspring body composition

2016

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Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants whose exposure levels are associated with various health hazards. We hypothesized that in utero and lactational exposure to PCBs can cause changes in body composition and obesity in a mouse model. Pregnant mice were exposed biweekly to two concentrations of PCB 126 via oral gavage. Maternal PCB exposure did not result in heavier offspring, however, dose-dependent and sex specific changes in body composition were observed. Female offspring displayed the most susceptibility to PCBinduced alterations in body composition, having less percent lean body mass and increased adiposity compared to females born to control dams, and these effects were largely dosedependent. In contrast to females, and independent of the exposure level of PCB 126, male offspring had reduced lean body mass but no change in fat mass compared to males born to control dams. In conclusion, perinatal PCB 126 exposure did not affect body weight, but rather modulated body composition in a dose-dependent and gender-specific manner.

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“…Daughters' probability of pregnancy fell by 32% per 10μg/L p,p'-DDT in maternal serum, but increased 16% per 10μg/L p,p'-DDE. Axmon et al (2006), in a big study of INUENDO, evaluating exposure to CB-153 (biphenyl) and p,p'-DDE found no effect on TTP of either male or female exposure in Sweden, Poland and Ukraine. In Greenland there seemed to be an association, but it was not possible to determine if it was due to CB-153 or p,p'-DDE.…”

Section: Pesticide Exposure and Health Related Issues In Male And Femmentioning

confidence: 96%

“…One found decreased fecundity related to exposure (Gerhard et al, 1999) and three of the studies indicated no significant association (Law et al, 2005;Axmon et al, 2006;Harley et al, 2008). Two studies examined DDE exposure in women undergoing IVF with contrary results (Jarrell et al, 1993;Younglai et al, 2002).…”

Section: Pesticides and Time To Pregnancymentioning

confidence: 99%

Pesticide Exposure and Health Related Issues in Male and Female Reproductive System

Sifakis¹,

Mparmpas²,

Tsatsakis³

2011

Pesticides - Formulations, Effects, Fate

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Time to pregnancy as a function of male and female serum concentrations of 2,2′4,4′5,5′-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p′-DDE)

Abstract: The overall results of the present study create a somewhat ambiguous pattern, but give some support to the idea that dietary POP exposure might be harmful for couple fertility.

Cited by 52 publications

References 48 publications

Male reproductive organs are at risk from environmental hazards

Male reproductive organs are at risk from environmental hazards

Perinatal polychlorinated biphenyl 126 exposure alters offspring body composition

Pesticide Exposure and Health Related Issues in Male and Female Reproductive System

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