Time to pregnancy and pregnancy outcome

Axmon, Anna; Hagmar, Lars

doi:10.1016/j.fertnstert.2005.04.030

Cited by 47 publications

(37 citation statements)

References 29 publications

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“…Previous studies have shown that polycystic ovarian syndrome patients have increased obstetric complications including higher rates of preeclampsia and gestational diabetes compared to other diagnoses [16] which may explain some of these differences. Prior studies in non-ART populations have also suggested that time-to-pregnancy can affect birth outcome [17]. Hypothetically, the longer it takes a woman to achieve pregnancy the more intractable her infertility might be.…”

Section: Discussionmentioning

confidence: 99%

Live birth rates and birth outcomes by diagnosis using linked cycles from the SART CORS database

Stern

Brown

Wantman³

et al. 2013

J Assist Reprod Genet

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Purpose This study uses linked cycles of assisted reproductive technology (ART) to examine cumulative live birth rates, birthweight, and length of gestation by diagnostic category. Methods We studied 145,660 women with 235,985 ART cycles reported to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System during 2004-2010. ART cycles were linked to individual women by name, date of birth, social security number, partner's name, and sequence of ART treatments. The study population included the first four autologous oocyte cycles for women with a single diagnosis of male factor, endometriosis, ovulation disorders, diminished ovarian reserve, or unexplained infertility. Live birth rates were calculated per cycle, per cycle number (1-4), and cumulatively. Birthweight and length of gestation were calculated for singleton births. Results Within each diagnosis, live birth rates were highest in the first cycle and declined with successive cycles. Women with diminished ovarian reserve had the lowest live birth rate (cumulative rate of 28.3 %); the live birth rate for the other diagnoses were very similar (cumulative rates from 62.1 % to 65.7 %). Singleton birthweights and lengths of gestation did not differ substantially across diagnoses, ranging from 3,112 to 3,286 g and 265 to 270 days, respectively. These outcomes were comparable with national averages for singleton births in the United States (3,296 g and 271 days). Conclusion Women with the diagnosis of diminished ovarian reserve had substantially lower live birth rates. However, singleton birthweights and lengths of gestation outcomes were similar across all other diagnoses.

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Section: Discussionmentioning

confidence: 99%

Live birth rates and birth outcomes by diagnosis using linked cycles from the SART CORS database

Stern

Brown

Wantman³

et al. 2013

J Assist Reprod Genet

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“…Seventy per cent of the sexual cycles of multiparous female baboons are nonconceptive (Gesquiere et al, in press); that is, the female has a complete and apparently normal sexual cycle and mates repeatedly but does not conceive an offspring (interestingly, this value of 70% reflects a fecundability not dissimilar to women in industrialized societies, for whom median time to conception is between two and three cycles, reflecting a higher than 50% rate of cycling without conception; Tuntiseranee et al 1998;Axmon & Hagmar 2005). The frequency of nonconceptive cycles is much higher for adolescent female baboons (Gesquiere et al, in press).…”

Section: Stage 2: Allocating Mating Effortmentioning

confidence: 99%

Sexual selection in wild baboons: from mating opportunities to paternity success

2006

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In mammals, high dominance rank among males is often associated with mating success. However, mating opportunities do not automatically translate into offspring production; observed mating success may be discordant with offspring production, for three reasons.(1) Observed mating may be nonrepresentative of actual mating if some mating is surreptitious (decreasing the chance that it will be observed), (2) mating may be nonrandom if some males allocate more mating effort to females with high fertility (i.e. if some males differentially invest in higher fertility mating) and (3) conception success may be nonrandom if sperm competition or sperm selection play a role in conception. We performed a genetic analysis of paternity in the well-studied savannah baboon, Papio cynocephalus, population in the Amboseli basin, eastern Africa, in order to measure the concordance between observed mating success and actual offspring production. We found that observed mating success was generally a good predictor of paternity success, that high-ranking males had higher paternity success than lower-ranking males, and that male density and male rank stability contributed to variance in male paternity success. We found little evidence for successful surreptitious mating (although subadult males did occasionally produce offspring, apparently using this strategy), and no clear evidence for differential sperm success or sperm depletion (although we could not rule them out). However, we found clear evidence that high-ranking males showed mate choice, concentrating their mating efforts on females experiencing conceptive rather than nonconceptive cycles.

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“…The higher prevalence of these morbidities may relate to treatment, or indicate that subfertility predisposes to a higher risk for PTB and LBW. Whereas the prevalence of PTB and LBW is increased among women receiving treatment for subfertility (other than IVF), it also increased in untreated women having a prolonged time-to-pregnancy, suggesting that there may be factors that both decrease reproductive efficiency and increase the risk for adverse pregnancy outcomes, such as PTB and LBW (Joffe and Li, 1994;Basso and Baird, 2003;Axmon and Hagmar, 2005;Zhu et al, 2007;Allen et al, 2008;Romundstad et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Examining the relationship between ovarian reserve, as measured by basal FSH levels, and the risk of poor obstetric outcome in singleton IVF gestations

2011

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background: The higher prevalence of preterm birth (PTB) and low birthweight (LBW) following infertility treatment may relate to the treatment itself or indicate that subfertility predisposes to a higher risk. Our aim was to examine whether basal FSH levels are related to the risk for PTB and LBW among pregnancies resulting from IVF. methods:We studied a retrospective cohort in the 2008 National Society for Assisted Reproductive Technology Database, including all women who underwent a fresh non-donor IVF cycle resulting in a singleton live birth having a recorded basal serum FSH value (n ¼ 14 262). The FSH value used was either the maximum basal or clomiphene-stimulated serum level. Log binomial models were created to assess the associations between FSH and PTB (,37 weeks), and between FSH and LBW (,2500 g), adjusting for maternal age, ethnicity, gravidity/ parity, history of PTB, smoking, BMI and infant gender.results: Data for 14 086 patients were analyzed. FSH levels were inversely related to the risk of PTB and LBW. Women in the highest quartile of FSH levels (≥9 mIU/ml) had the longest adjusted mean gestational age (271.2 days), the lowest adjusted relative risk (RR) of PTB [0.87, 95% confidence interval (CI): 0.76 -1.01], the highest adjusted mean birthweight (3249 g) and the lowest adjusted RR of LBW (0.89, 95% CI: 0.73 -1.04).conclusions: The inverse relationship between maximal basal FSH levels and the risk for PTB and LBW in singleton IVF gestations suggests that diminished ovarian reserve is not the primary mediator of the increased prevalence of PTB and LBW in IVF pregnancies.

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Time to pregnancy and pregnancy outcome

Cited by 47 publications

References 29 publications

Live birth rates and birth outcomes by diagnosis using linked cycles from the SART CORS database

Live birth rates and birth outcomes by diagnosis using linked cycles from the SART CORS database

Sexual selection in wild baboons: from mating opportunities to paternity success

Examining the relationship between ovarian reserve, as measured by basal FSH levels, and the risk of poor obstetric outcome in singleton IVF gestations

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