Abstract:Objective: To investigate the time to maximal platelet inhibition after an oral loading dose of ASA. The effect of ex vivo reversal platelet inhibition by desmopressin (DDAVP) was also studied.Methods: Ten healthy volunteers were given a 300 mg ASA-tablet. Blood was sampled at 0, 15, 30, 60, 120, and 180 minutes. DDAVP was added to the samples taken at 120 minutes.Samples were analyzed with a Multiplate® platelet aggregometer (MEA) using arachidonic acid (AA), collagen, and thrombin aggregation agonists.Result… Show more
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