Time‐to‐market, window of opportunity, and salvageability of a new product development

Messica, Avi; Mehrez, Abraham

doi:10.1002/mde.1074

Cited by 10 publications

(7 citation statements)

References 12 publications

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“…It is worthy to note that, over the last few years, many studies have focused on the uptake of human and bovine milk EVs in various cell types. These studies have not only successfully demonstrated the uptake of milk EVs by IECs [ 105 , 114 , 117 , 118 ] but also macrophages [ 102 ] and vascular endothelial cells [ 119 ]. Milk EVs have also been demonstrated to be able to cross blood brain barrier.…”

Section: Milk As a Biofluid In Interindividual And Cross-species Cmentioning

confidence: 99%

Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery

et al. 2020

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Milk is considered as more than a source of nutrition for infants and is a vector involved in the transfer of bioactive compounds and cells. Milk contains abundant quantities of extracellular vesicles (EVs) that may originate from multiple cellular sources. These nanosized vesicles have been well characterized and are known to carry a diverse cargo of proteins, nucleic acids, lipids and other biomolecules. Milk-derived EVs have been demonstrated to survive harsh and degrading conditions in gut, taken up by various cell types, cross biological barriers and reach peripheral tissues. The cargo carried by these dietary EVs has been suggested to have a role in cell growth, development, immune modulation and regulation. Hence, there is considerable interest in understanding the role of milk-derived EVs in mediating inter-organismal and cross-species communication. Furthermore, various attributes such as it being a natural source, as well as its abundance, scalability, economic viability and lack of unwarranted immunologic reactions, has generated significant interest in deploying milk-derived EVs for clinical applications such as drug delivery and disease therapy. In this review, the role of milk-derived EVs in inter-organismal, cross-species communication and in drug delivery is discussed.

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Section: Milk As a Biofluid In Interindividual And Cross-species Cmentioning

confidence: 99%

Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery

et al. 2020

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“…Development cycle time, defined as the elapsed time from the beginning of idea generation when the firm decided to develop a new product to the moment the product is ready for market introduction, is consistent with the notion of time to market (Messica and Mehrez, 2002), innovation time (Mansfield, 1988), total time (Griffin, 1993), and lead time (Clark, 1989). There are different viewpoints with regard to the effect of development cycle time on development costs (cf.…”

Section: Hypothesesmentioning

confidence: 99%

Exploring Mediating and Moderating Influences on the Links among Cycle Time, Proficiency in Entry Timing, and New Product Profitability^*

Langerak

Hultink

Griffin

2008

J of Product Innov Manag

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Development cycle time is the elapsed time from the beginning of idea generation to the moment that the new product is ready for market introduction. Market-entry timing is contingent upon the new product's cycle time. Only when the product is completed can a firm decide whether and when to enter the market to exploit the new product's window of opportunity. To determine the right moment of entry a firm needs to correctly balance the risks of premature entry and the missed opportunity of late entry. Proficient market-entry timing is therefore defined as the firm's ability to get the market-entry timing right (i.e., neither too early nor too late). The literature has produced divergent evidence with regard to the effects of development cycle time and proficiency in market-entry timing on new product profitability. To explain these disparities this study (1) explores the mediating roles of development costs and sales volume in the relationships among development cycle time, proficiency in market-entry timing, and new product profitability, respectively; and it (2) explores the moderating influence of product newness on the relationship between development cycle time and development costs and that of new product advantage on the link between proficiency in market-entry timing and sales volume. The results from a survey-based study of 72 manufacturers of industrial products in the Netherlands suggest that development costs mediate the relationship between development cycle time and new product profitability and that sales volume mediates the link between proficiency in market-entry timing and new product profitability. In addition, the findings indicate that new product advantage strengthens the positive relationship between proficiency in market-entry timing and sales volume. The results provide no evidence for a moderating effect of product newness. These results have important implications because to maximize new product profitability managers need to distinguish between costs and demand side effects of development cycle time and market-entry timing on new product profitability. Keeping this distinction in mind should help them to better determine the relative profit impact of investments in cycle time reduction or improved entry timing. Moreover, the findings suggest that highly advantaged products that enter the market at the right time may have a highly attenuated sales volume. It also implies that new products with lower advantage may have very little leeway in hitting the ''sweet spot'' in market. The message is that ''doing the right thing'' (i.e., to develop a highly advantaged Ã The authors would like to thank the editor and two anonymous reviewers for their comments on the previous versions of this manuscript. They also appreciate the comments of seminar participants at the University of Groningen. The authors acknowledge the financial support from the

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“…A necessary condition of opportunity identification is the creation or appearance of a window of opportunity. In interpreting the understanding of opportunity as proposed by [Casson, 1982], we suggest that the window of opportunity [Messica, Mehrez, 2002;Suarez et al, 2015] is a collection of situations and conditions that allow for identifying and implementing an opportunity. In other words, an entrepreneurial ecosystem and its pillars together with timing form the window of opportunity.…”

Section: From the Entrepreneurial Ecosystem To A Window Of Opportunitymentioning

confidence: 99%

Untitled

2019

Foresight and STI Governance

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is an international interdisciplinary peer-reviewed openaccess journal. It publishes original research articles, offering new theoretical insights and practice-oriented knowledge in important areas of strategic planning and the creation of science, technology, and innovation (STI) policy, and it examines possible and alternative futures in all human endeavors in order to make such insights available to the right person at the right time to ensure the right decision. The journal acts as a scientific forum, contributing to the interaction between researchers, policy makers, and other actors involved in innovation processes. It encompasses all facets of STI policy and the creation of technological, managerial, product, and social innovations. Foresight and STI Governance welcomes works from scholars based in all parts of the world. Topics covered include: • Foresight methodologies and best practices; • Long-term socioeconomic priorities for strategic planning and policy making; • Innovative strategies at the national, regional, sectoral, and corporate levels; • The development of National Innovation Systems; • The exploration of the innovation lifecycle from idea to market; • Technological trends, breakthroughs, and grand challenges; • Technological change and its implications for economy, policy-making, and society; • Corporate innovation management; • Human capital in STI; and many others. The target audience of the journal comprises research scholars, university professors, postgraduates, policy-makers, business people, the expert community, undergraduates, and others who are interested in S&T and innovation analyses, foresight studies, and policy issues.

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Time‐to‐market, window of opportunity, and salvageability of a new product development

Cited by 10 publications

References 12 publications

Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery

Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery

Exploring Mediating and Moderating Influences on the Links among Cycle Time, Proficiency in Entry Timing, and New Product Profitability^*

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Time‐to‐market, window of opportunity, and salvageability of a new product development

Cited by 10 publications

References 12 publications

Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery

Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery

Exploring Mediating and Moderating Influences on the Links among Cycle Time, Proficiency in Entry Timing, and New Product Profitability*

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Exploring Mediating and Moderating Influences on the Links among Cycle Time, Proficiency in Entry Timing, and New Product Profitability^*