Background: Burnout syndrome is emotional exhaustion (EE), depersonalization (DP) and reduces personal accomplishment (PA).Burnout is resulted from long-term exposure to personal and/or workrelated stressors and those stressors are negative effect on midwives' performance of care and mitigate maternal mortality. Profession-related stress among midwives has deleterious effects on their professional, physical, and psychological health. Objective: The study aims to assess the prevalence and associated factors of burnout among midwives work in East Amhara governmental hospital Ethiopia 2022. Methods: A facilitybased cross cross-sectional study design was carried out. Two hundred sixteen (216) study participants were included in this study from 01 March 2021 -01 May 2021 working in 11 governmental hospitals in North Shoa, 12 governmental hospitals in South Wollow, 6 governmental hospitals in North Wollow, 1 each from Oromia special Zone and Wagehemera Zones governmental hospitals. A simple Random sampling method was used for selection. Structured and pre-test questionnaires were used. The data were cleaned and checked using Epi info version 3.1 and exported to SPSS version 23 for analysis. Hosmer-Lemeshow goodness fit test and multicollinearity were checked. Bi-variable analysis was executed for variables with p-value of < 0.25 and entered into multivariable logistic regression. Multivariate analysis, AOR, 95% CI and p-value <0.05 were used to identify variables which had association with dependant variable. Data was collected through face-to-face interview.A structured questionnaire was adapted from mental health disorder questionnaire developed by Ethiopian psychiatry association. Pre-test of questionnaire was carried out on 1 referral and 1 primary hospital which are all found out of the study area.