Time to embrace PROMIS-29 as the standard health-related quality of life instrument for patients with cirrhosis

Tapper, Elliot B.; Lai, Jennifer C.

doi:10.1097/hep.0000000000000508

Cited by 2 publications

(1 citation statement)

References 11 publications

(18 reference statements)

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“…Third, the Patient Reported Outcomes Measurement Information System-29 (PROMIS-29) has recently been proposed as the superior instrument for health-related QoL research among patients with cirrhosis given its validity, ease of use, and absence of floor or ceiling effects. 48 , 49 Nevertheless, the validated Short Form LDQoL chosen for this study was considered appropriate for our research questions as it included both liver-specific and general QoL domains. 21 , 23 , 50 Finally, cross-sectional data were analyzed, and so the direction of effects could not be ascertained.…”

Section: Discussionmentioning

confidence: 99%

Problematic alcohol use and its impact on liver disease quality of life in a multicenter study of patients with cirrhosis

Luk,

Satre,

Cheung

et al. 2024

Hepatology Communications

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Background: Management of cirrhosis is challenging and has been complicated by the COVID-19 pandemic due to decreased access to care, increased psychological distress, and alcohol misuse. Recently, The National Institute on Alcohol Abuse and Alcoholism has broadened the definition of recovery from alcohol use disorder to include quality of life (QoL) as an indicator of recovery. This study examined the associations of alcohol-associated cirrhosis etiology and problematic drinking with liver disease QoL (LDQoL). Methods: Patients with cirrhosis (N=329) were recruited from 3 sites (63% from 2 Veterans Affairs Health Care Systems and 37% from 1 safety net hospital) serving populations that are economically or socially marginalized. Cirrhosis etiology was ascertained by chart review of medical records. Problematic drinking was defined by ≥8 on the Alcohol Use Disorders Identification Test. Multivariable general linear modeling adjusting for age, sex, race/ethnicity, site, pandemic-related stress, and history of anxiety/depressive disorder were conducted. Sensitivity analyses further adjusted for indicators of liver disease severity. Results: Participants were on average 64.6 years old, 17% female, 58% non-White, 44% with alcohol-associated cirrhosis, and 17% with problematic drinking. Problematic drinking was significantly associated with worse LDQoL scores in the overall scale and in the memory/concentration and health distress subscales. These associations remained significant after adjusting for indicators of liver disease severity, including Model for End-Stage Liver Disease-Sodium score and decompensated cirrhosis status. Conclusions: Among patients with cirrhosis, problematic drinking was associated with worse LDQoL, especially in the domains of memory/concentration and health distress. Assessment and awareness of cognitive deficits and negative emotionality within the context of cirrhosis and problematic drinking may help clinicians provide better integrated care for this population.

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Section: Discussionmentioning

confidence: 99%

Problematic alcohol use and its impact on liver disease quality of life in a multicenter study of patients with cirrhosis

Luk,

Satre,

Cheung

et al. 2024

Hepatology Communications

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The Liver Cirrhosis Network Cohort Study: Cirrhosis Definition, Study Population, and Endpoints

Tapper,

Goldberg,

Parikh

et al. 2024

Am J Gastroenterol

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Background: One of the primary goals of the Liver Cirrhosis Network (LCN) is to develop a cohort study to better understand and predict the risk of hepatic decompensation and other clinical and patient-reported outcomes among patients with Child A cirrhosis. Methods: The LCN consists of a Scientific Data Coordinating Center (SDCC) and 10 clinical centers whose investigators populate multiple committees. The LCN Definitions and Measurements Committee developed preliminary definitions of cirrhosis and its complications by literature review, expert opinion, and reviewing definition documents developed by other organizations. The Cohort Committee developed the study protocol with the input of the steering committee. Results: The LCN developed a prospective cohort study to describe and predict the rates of incident clinical events pertaining to first decompensation and patient reported outcomes. The LCN developed a pragmatic definition of compensated cirrhosis incorporating clinical, laboratory, imaging, and histological criteria. Definitions of incident and recompensated ascites, overt hepatic encephalopathy, variceal hemorrhage, bleeding due to portal gastropathy, and hepatocellular carcinoma were also codified. Conclusion: The LCN Cohort Study design will inform the natural history of cirrhosis in contemporary patients with compensated cirrhosis. The LCN Definitions and Measures Committee developed criteria for the definition of cirrhosis to standardize entry into this multi-center cohort study and standardized criteria for liver-related outcome measures. This effort has produced definitions intended to be both sensitive and specific as well as easily operationalized by study staff such that outcomes critical to the LCN cohort are identified and reported in an accurate and generalizable fashion.

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Time to embrace PROMIS-29 as the standard health-related quality of life instrument for patients with cirrhosis

Cited by 2 publications

References 11 publications

Problematic alcohol use and its impact on liver disease quality of life in a multicenter study of patients with cirrhosis

Problematic alcohol use and its impact on liver disease quality of life in a multicenter study of patients with cirrhosis

The Liver Cirrhosis Network Cohort Study: Cirrhosis Definition, Study Population, and Endpoints

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