Time to Diagnostic Colonoscopy and Colonoscopic Findings after Positive fit in an Ethnically Diverse Cohort of U.S. Veterans

Phan, Jennifer; Yu, Christine; Reid, Mark W.; Ehrlich, Dean; Lin, Lisa; Storage, Tina; Jamaluddin, Nimah; Dinh, Doantrang; Aby, Elizabeth S.; Bharath, Purnima; Pisegna, Joseph R.; May, Folasade P.

doi:10.1016/s0016-5085(17)31965-0

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“…2 In the last decade, new imaging techniques have been developed for early detection of inflammatory lesions, which has resulted in a significant reduction in the incidences of CRC. [3][4][5][6] However, the etiology of IBDs remains unclear due to its heterogeneous disorders with various appearances. In the previous study, the inflammation of UC has been mainly observed in the mucosal and submucosal layers; however, in CD, the inflammation has been scattered and may be found in all the layers of colon.…”

Section: Introductionmentioning

confidence: 99%

Multiscale imaging of colitis in mice using confocal laser endomicroscopy, light-sheet fluorescence microscopy, and magnetic resonance imaging

Hui

et al. 2019

J. Biomed. Opt.

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The objective of our study is to develop a multimodality approach by combining magnetic resonance imaging (MRI) and optical imaging methods to assess acute murine colitis at the macro-and microscopic level. In vivo MRI is used to measure the cross-sectional areas of colons at the macroscopic level. Dual-color confocal laser endomicroscopy (CLE) allows in vivo examination of the fluorescently labeled epithelial cells and microvessels in the mucosa with a spatial resolution of ∼1.4 μm during ongoing endoscopy. To further validate the structural changes of the colons in three-dimensions, ex vivo light-sheet fluorescence microscopy (LSFM) is applied for in-toto imaging of cleared colon sections. MRI, LSFM, and CLE findings are significantly correlated with histological scoring (p < 0.01) and the inflammation-associated activity index (p < 0.01). Our multimodality imaging technique permits visualization of mucosa in colitis at different scales, which can enhance our understanding of the pathogenesis of inflammatory bowel diseases.

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Section: Introductionmentioning

confidence: 99%

Multiscale imaging of colitis in mice using confocal laser endomicroscopy, light-sheet fluorescence microscopy, and magnetic resonance imaging

Hui

et al. 2019

J. Biomed. Opt.

View full text Add to dashboard Cite

show abstract

Time to Diagnostic Colonoscopy and Colonoscopic Findings after Positive fit in an Ethnically Diverse Cohort of U.S. Veterans

Cited by 1 publication

References 0 publications

Multiscale imaging of colitis in mice using confocal laser endomicroscopy, light-sheet fluorescence microscopy, and magnetic resonance imaging

Multiscale imaging of colitis in mice using confocal laser endomicroscopy, light-sheet fluorescence microscopy, and magnetic resonance imaging

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