Time to diagnosis of retinoblastoma in Latin America: A systematic review

Mattosinho, Clarissa; Moura, Anna Tereza Miranda Soares de; Oigman, Gabriela; Ferman, Sima; Grigorovski, Nathalia

doi:10.1080/08880018.2019.1605432

Cited by 20 publications

(30 citation statements)

References 49 publications

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“…25 RB outcome is extremely time-related, and late diagnosis is a recognized cause of poorer prognosis. 11,12,27,28 Consequently, delay to start or proceed with treatment causes similar adverse effects on outcomes. It has been demonstrated that RB, as well as CNS tumors, has a high treatment abandonment rate, 29 possibly because it frequently involves a mutilating procedure such as enucleation in order to achieve cure.…”

Section: Discussionmentioning

confidence: 99%

“…10 In LMIC, RB is still life-threatening, with survival rates as low as 50%, triggered by poor socioeconomic conditions 8 and late diagnoses. [11][12][13][14] RB may present a unique setting to assess SES disparities for nonhematological solid tumors. Several socioeconomic factors and others related to health education can contribute to RB late diagnosis, including illiteracy, poverty, lack of trained health professionals, unawareness about early signs, precarious health care structure, lack of access to the health system, and vulnerability.…”

Section: Introductionmentioning

confidence: 99%

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Socioeconomic status and retinoblastoma survival: Experience of a tertiary cancer center in Brazil

Mattosinho

Moura

Grigorovski

et al. 2020

Pediatric Blood & Cancer

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Background: Little is known about socioeconomic status (SES) and its effects in childhood cancer survival. This study aims to discuss the association between SES and survival of patients with retinoblastoma (RB) from a tertiary treatment center. Procedure: A retrospective cohort study was conducted, including all patients with RB referred to the Brazilian National Institute of Cancer in Rio de Janeiro (January 2000-December 2016). Results: Data from 160 patients were analyzed with mean age at diagnosis of 22.85 months (SD ± 14.29). Eighty-three patients (51.9%) had an interval to diagnosis equal to or longer than six months, and 13 children (8.1%) abandoned treatment. Five-year overall survival rate for all patients was 78.8% (95% CI, 72.4%-85.9%). In a multivariate model, patients whose fathers had more than nine years of study had a lower death risk. Patients from families having more than one child under five years had a 213% higher risk of death compared with those living with no other small child. Treatment abandonment also had a profound effect on death risk. Conclusion: Childhood cancer is notably important considering the potential years of life lost. RB has even more important elements, as the possibility of vision loss in cases with delayed diagnosis. Family characteristics seem to be highly related to RB survival, especially in low-and middle-income countries, where inequalities are still a public health issue. Strategies to improve survival should focus not only on large-scale settings such as improving national healthcare systems but also on more personalized actions that might help to mitigate disparities.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Socioeconomic status and retinoblastoma survival: Experience of a tertiary cancer center in Brazil

Mattosinho

Moura

Grigorovski

et al. 2020

Pediatric Blood & Cancer

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“…Murali Chintagumpala Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA In this issue of Pediatric Hematology and Oncology, there are three reports addressing the management of Retinoblastoma in Low-and Middle-Income Countries (LMIC) [1][2][3]. Retinoblastoma is the most common malignant intraocular tumor affecting children.…”

Section: Retinoblastoma In Low-and Middle-income Countriesmentioning

confidence: 99%

“…Some of the contributing factors that increase the TTD especially in LMIC are lack of immediate access to medical care, parental education, and socioeconomic factors. However, as the report by Campolina et al [1] shows, it is difficult to assess the length of TTD and the outcome of patients especially in LMIC where a prolonged TTD is likely to have an adverse effect on outcome. The data are retrospective and the focus and emphasis are more on the treatment and outcome than with the causes and effects of prolonged TTD.…”

Section: Retinoblastoma In Low-and Middle-income Countriesmentioning

confidence: 99%

Retinoblastoma in Low- and Middle-Income Countries

Chintagumpala

2019

Pediatric Hematology and Oncology

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“…4,5 The median time to diagnosis, the interval from symptom onset to diagnosis, ranges from 3 to 5 months and delayed diagnosis has been related to detrimental results on retinoblastoma sequelae, particularly with regard to increasing extraocular extension and mortality rates. 1 Investigation of novel active proteins or signaling cascades involved in intraocular retinoblastoma might contribute to early diagnosis.…”

mentioning

confidence: 99%

TRIM59 Promotes Retinoblastoma Progression by Activating the p38–MAPK Signaling Pathway

Shang

You

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Retinoblastoma is a malignant tumor of the developing retina that mostly occurs in children. Our study aimed to investigate the effect of tripartite motif-containing protein 59 (TRIM59) on retinoblastoma growth and the underlying mechanisms. METHODS. We performed bioinformatic analysis of three datasets (GSE24673, GSE97508, and GSE110811) from the Gene Expression Omnibus database. Quantitative reversetranscription PCR and immunoblotting of three retinoblastoma cell lines were conducted to verify TRIM59 as a differentially expressed gene. Specific siRNAs were used to inhibit TRIM59 expression in the HXO-Rb44 cell line. A lentiviral vector was transfected into the Y79 cell line to overexpress TRIM59. The effects of TRIM59 on retinoblastoma cell proliferation, cell cycling, and apoptosis were explored in vitro using the abovementioned cell lines. The effect of TRIM59 expression on retinoblastoma cell proliferation was evaluated in a mouse xenograft tumor model. RESULTS. TRIM59 expression in three retinoblastoma cell lines was remarkably elevated compared with normal control. Knocking down TRIM59 expression remarkably suppressed cell proliferation and growth and promoted cell apoptosis in HXO-Rb44 cells, whereas TRIM59 overexpression promoted tumor progression in Y79 cells. Silencing TRIM59 also markedly inhibited in vivo tumor growth in the xenograft model. Mechanistic studies revealed that TRIM59 upregulated phosphorylated p38, p-JNK1/2, p-ERK1/2, and p-c-JUN expression in retinoblastoma cells. Notably, the p38 inhibitor SB203580 attenuated the effects of TRIM59 on cell proliferation, apoptosis, and the G 1 /S phase transition. CONCLUSIONS. TRIM59 plays an oncogenic role in retinoblastoma and exerts its tumorpromotive function by activating the p38-mitogen-activated protein kinase pathway.

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Time to diagnosis of retinoblastoma in Latin America: A systematic review

Cited by 20 publications

References 49 publications

Socioeconomic status and retinoblastoma survival: Experience of a tertiary cancer center in Brazil

Socioeconomic status and retinoblastoma survival: Experience of a tertiary cancer center in Brazil

Retinoblastoma in Low- and Middle-Income Countries

TRIM59 Promotes Retinoblastoma Progression by Activating the p38–MAPK Signaling Pathway

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