2014
DOI: 10.1200/jco.2013.53.8058
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Time to Diagnosis of Ewing Tumors in Children and Adolescents Is Not Associated With Metastasis or Survival: A Prospective Multicenter Study of 436 Patients

Abstract: TtD of Ewing tumors was long, especially for adolescents and for certain tumor sites, and did not improve over time. But TtD was not associated with metastasis, surgical outcome, or survival. These findings could be used to comfort parents at diagnosis and in expert testimony produced for malpractice claims.

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Cited by 63 publications
(67 citation statements)
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“…Pending such confirmatory efforts, we judge it appropriate to attempt a discussion on the practical implications of our findings. When some authors of earlier studies found no correlation between time to diagnosis and outcome, they concluded that efforts to reduce the symptom interval could yield psychological benefits at most, not a substantially better prognosis . We consider such a claim potentially dangerous.…”
Section: Discussionmentioning
confidence: 99%
“…Pending such confirmatory efforts, we judge it appropriate to attempt a discussion on the practical implications of our findings. When some authors of earlier studies found no correlation between time to diagnosis and outcome, they concluded that efforts to reduce the symptom interval could yield psychological benefits at most, not a substantially better prognosis . We consider such a claim potentially dangerous.…”
Section: Discussionmentioning
confidence: 99%
“…Time to diagnosis is one of the longest as compared to other pediatric tumors; however, it is not associated with worsened prognosis. [7] The most frequent sites of origin in decreasing order of the prevalence include the paravertebral region, lower extremity, chest wall, retroperitoneum, pelvis, and hip. [7] The lung is the most common site of metastatic spread.…”
Section: Discussionmentioning
confidence: 99%
“…[7] The most frequent sites of origin in decreasing order of the prevalence include the paravertebral region, lower extremity, chest wall, retroperitoneum, pelvis, and hip. [7] The lung is the most common site of metastatic spread. [8]…”
Section: Discussionmentioning
confidence: 99%
“…Recently, Brasme et al 11 analysed the effect of time to diagnosis of Ewing's tumours on metastasis and survival, in children and adolescents. Their prospective study of 436 patients with Ewing's sarcoma showed that survival was not significantly associated with time to diagnosis, though the authors acknowledge the psychological toll of a delayed diagnosis.…”
Section: Discussionmentioning
confidence: 99%